Why did you choose to inject glucose after being drunk?
The reason why glucose is the first choice for drunken infusion during the Spring Festival
It's the Spring Festival, and it's the high season for drunkenness. It's a consensus that glucose is the first choice for drunkards when infusion, but few people can specify the reasons for choosing glucose infusion. Today, I'll give you a general introduction.
Glucose and ethanol
Glucose is one of the main energy-supplying substances in the human body. After glucose enters the blood, it is transported through the blood to various tissue cells for synthesis and catabolism to supply energy to the body. Oxidative decomposition in various tissues provides energy, which is the main function of glucose.
After drinking alcohol, the ethanol in the wine is completely absorbed through the stomach and small intestine within 0.5 to 3 hours, and distributed in all aqueous tissues and body fluids of the body. Although ethanol is widely distributed in the body, 90% is decomposed and metabolized in the liver. Excessive concentration of ethanol in the blood not only causes some symptoms and complications of intoxication, but also requires a lot of energy in the metabolic process of ethanol, and its energy source depends on the supply of glucose.
So, in addition to providing energy to the body, what are the effects of glucose infusion on ethanol metabolism?
Effect of glucose infusion
1. Accelerate ethanol removal
After glucose infusion, blood sugar increases, blood volume increases, and the excretion of body fluids through the urine of the kidneys is accelerated. Therefore, glucose infusion after intoxication accelerates the excretion of ethanol through urination, which can relieve the state of intoxication.
2. Accelerate ethanol decomposition
After drinking alcohol, the liver needs a lot of energy to catabolize alcohol, and providing glucose can speed up the catabolism of alcohol. There are also views that glucose infusion has the effect of protecting the liver and protecting the liver, but there is still a lack of sufficient evidence to confirm it.
3. Correct hypoglycemia
During ethanol metabolism, complex changes such as changes in the ratio of NADH/NAD, reduced galactose tolerance, increased triglyceride synthesis, and increased lipid peroxidation occur, so hypoglycemia occurs after drinking alcohol. Hypoglycemia generally occurs 6 to 24 hours after moderate or heavy drinking, but it can also occur soon after drinking, and the blood sugar concentration is generally <1.7 mmol/L. Therefore, glucose infusion is a straightforward and effective way to correct the hypoglycemic state after drinking.
Infusion method
1. Light and moderate drinkers without disturbance of consciousness can receive intravenous infusion while inhaling oxygen, keeping warm, and ECG monitoring:
| 5% glucose saline | 500 mL |
|---|---|
| Vitamin B6 | 50~ 100 mg |
| Vitamin B1 | 50~ 100 mg |
2. Acute disorders of consciousness, in order to accelerate the oxidation of ethanol in the body, consider:
| 50% glucose 100 mL, iv | |
| Vitamin B1 100 mg, im | |
| Vitamin B6 100 mg, im |
3. For those who are restless or overexcited, small doses of diazepam can be used, and morphine, chlorpromazine, and phenobarbital sedatives can be avoided.
