Toxicity
CHEMICAL IDENTIFICATION
RTECS NUMBER :
VB8225000
CHEMICAL NAME :
Quinoline,
6-ethoxy-1,2-dihydro-2,2,4-trimethyl-
CAS REGISTRY NUMBER :
91-53-2
LAST UPDATED
:
199710
DATA ITEMS CITED :
17
MOLECULAR FORMULA :
C14-H19-N-O
MOLECULAR
WEIGHT :
217.34
WISWESSER LINE NOTATION :
T66 BM CHJ C1 C1 E1 HO2
HEALTH HAZARD
DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent
kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1730 mg/kg
TOXIC
EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF
TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200
mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose
value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE
:
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
178
mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting
reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - coma
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - rat
DOSE/DURATION :
14377 mg/kg/3W-C
TOXIC EFFECTS
:
Blood - change in clotting factors
TYPE OF TEST :
TDLo - Lowest published toxic
dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION
:
63 gm/kg/30W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder
weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF
TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES
OBSERVED :
Rodent - rat
DOSE/DURATION :
122 gm/kg/58W-C
TOXIC EFFECTS
:
Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
TDLo - Lowest published
toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent -
rat
DOSE/DURATION :
12 gm/kg/29W-C
TOXIC EFFECTS :
Liver - changes in liver
weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute
tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight
MUTATION
DATA
TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
13 gm-kg/4W
(Continuous)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press,
Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 99,37,1989 ***
U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR
RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH
STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83809 No. of
Facilities: 204 (estimated) No. of Industries: 3 No. of Occupations: 13 No. of Employees:
3572 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code -
83809 No. of Facilities: 876 (estimated) No. of Industries: 6 No. of Occupations: 14 No. of
Employees: 7945 (estimated)
