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Product Name: Vitamin K3
Chemical Name: Menadione
Synonyms: 2-Methyl-1,4-naphthoquinone, Menaphthone
CAS Number: 58-27-5
Recommended Use: Nutritional supplement, animal feed additive
Manufacturer/Supplier: Manufacturer details, emergency contact numbers, address, and telephone available on shipping documents
Classification: Irritant, harmful if swallowed, potential sensitizer
Label Elements: Hazard symbols (Xn, Xi), warning phrase "Harmful", risk statements include "Irritating to eyes, respiratory system, skin", "May cause sensitization by skin contact", precautionary phrases regarding use of personal protective equipment
Health Hazards: Inhalation can irritate the respiratory tract, skin contact may cause allergic reactions, eye exposure may lead to significant irritation, ingestion is harmful and may cause serious effects
Chemical Identity: Menadione
Concentration: Usually over 98% pure in standard pharmaceutical and feed grades
Impurities: Minor byproducts from synthesis, levels below 2%
Molecular Formula: C11H8O2
Molecular Weight: 172.18 g/mol
Inhalation: Move to fresh air, keep warm and at rest, seek medical attention for breathing difficulty
Skin Contact: Immediately wash with plenty of water, remove contaminated clothing, medical attention if irritation or rash develops
Eye Contact: Flush eyes with running water for at least 15 minutes, keep eyelids open, ensure medical advice
Ingestion: Rinse mouth thoroughly, never give anything by mouth to an unconscious person, contact medical authorities right away, monitor signs of toxicity such as nausea or dizziness
Suitable Extinguishing Media: Water spray, dry chemical powder, foam, carbon dioxide
Specific Hazards: Combustion produces toxic gases including carbon monoxide and carbon dioxide, smoke may contain irritating or hazardous fragments
Protective Equipment: Firefighters use self-contained breathing apparatus, full protective clothing recommended to avoid skin and respiratory exposure
Special Procedures: Avoid water runoff entering drains, evacuate area if large amounts burn
Personal Precautions: Wear gloves, protective goggles, dust mask, prevent inhalation and direct skin contact
Environmental Precautions: Prevent entry into sewers, streams, or public waters
Cleanup Methods: Sweep up spills carefully, place in labeled containers for disposal, ventilate contaminated area, wash spillage site with detergent and water after removal
Handling: Utilize chemical-resistant gloves, dust tight goggles, avoid formation of dust, provide adequate ventilation, avoid unnecessary contact, never eat, drink, or smoke during use, wash hands thoroughly
Storage: Store in tightly closed containers, in a cool, dry, well-ventilated location, keep away from oxidizers, acids, and incompatible materials, prevent moisture exposure, protect from direct sunlight
Exposure Limits: Occupational exposure limits not formally established in most countries, but general dust limits apply, for example, 10 mg/m³ for total dust (ACGIH TLV for nuisance particulates)
Engineering Controls: Use local exhaust ventilation, laboratory hoods or dust extraction systems
Personal Protection: Protective gloves, safety goggles, lab coat, dust mask or respirator suited for fine particles, safety shoes
Hygiene Measures: Wash thoroughly after handling, remove contaminated clothing, no food or drink near handling area
Appearance: Pale yellow crystalline powder, faint odor
Melting Point: 105–107°C
Boiling Point: Decomposes
Solubility: Slightly soluble in water, readily soluble in organic solvents like ethanol and chloroform
Vapor Pressure: Negligible at ambient temperature
Density: About 1.4 g/cm³
pH: Not applicable for solid powder
Chemical Stability: Stable under recommended storage conditions
Reactivity: Reactive with strong oxidizers, bases, and strong acids
Decomposition: Heating to decomposition produces toxic and corrosive fumes
Hazardous Polymerization: Will not occur under normal conditions
Compatibility: Avoid mixing with strong oxidants and reducing agents
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Oral LD50 (rat) ranges from 325 mg/kg to 400 mg/kg, classified as harmful if swallowed
Chronic Effects: Prolonged exposure can lead to allergic skin reactions, liver and kidney effects, animal studies indicate risk of hemolytic anemia
Irritation/Sensitization: Causes irritation to eyes, respiratory tract, skin; may trigger allergic responses in sensitive individuals
Carcinogenicity/Mutagenicity: Not listed as carcinogenic, no definitive human data, mutagenicity studies inconclusive in laboratory animals
Reproductive Toxicity: No confirmed reproductive toxicity at low exposure levels for humans, animal data limited
Ecotoxicity: Toxic to aquatic organisms, LC50 (fish, 96h) estimated at 5.2 mg/L
Persistence and Degradability: Not readily biodegradable, persistence expected in soil and water
Bioaccumulation Potential: Moderate, potential exists for bioaccumulation in aquatic organisms
Aquatic Mobility: Limited water solubility restricts mobility in river and lake systems
Other Effects: Spillage or runoff may pose risk to aquatic species, advised to avoid release to environment
Waste Disposal: Treat as hazardous waste, incinerate or dispose of in accordance with local, regional, and national regulations
Container Disposal: Empty containers must be decontaminated; triple rinse, puncture, and dispose of as hazardous waste
Avoidance: Releases to landfill or water systems pose long-term environmental impacts, professional disposal recommended
UN Number: Not regulated for transport under UN conventions in small quantities, bulk shipment may require UN 2811 (toxic solid, organic, n.o.s.)
Proper Shipping Name: Toxic solid, organic, n.o.s. (contains Menadione)
Hazard Class: 6.1 (toxic substances, where applicable)
Packing Group: III (if classified)
Label Requirements: Toxic
Special Precautions: Avoid contact with compatible goods, minimize dust generation and release, handle as potentially hazardous material during transit
Inventory Status: Listed on major chemical inventories such as TSCA (US), EINECS (EU), DSL (Canada)
Regulations: Occupational Safety and Health Act (OSHA) covers dust and hazardous substances, not specifically regulated by name in most jurisdictions
Labeling: Hazard pictograms for irritant and harmful substance apply, safety data sheets required for workplace handling
Worker Protection: Compliance with COSHH Regulations (UK), OSHA (US), WHMIS (Canada) required
Other: Environmental release thresholds, reporting obligations for bulk use under REACH (EU), SARA Title III (US) may apply depending on volume
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
