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Material Safety Data Sheet for Vitamin D2

Identification

Product Name: Ergocalciferol (Vitamin D2)
CAS Number: 50-14-6
Synonyms: Calciferol, Viosterol
Molecular Formula: C28H44O
Molecular Weight: 396.65 g/mol
Intended Use: Nutritional supplement, pharmaceutical applications
Manufacturer: Supplied by reputable chemical distributors
Emergency Telephone: Included in supplier labels

Hazard Identification

Classification: Not classified as hazardous by GHS standards in typical concentrations
Health Hazards: Overexposure may cause hypercalcemia, nausea, vomiting, weakness, and renal impairment
Environmental Hazards: Presents low risk to environment in standard laboratory quantities
Physical Hazards: Dust may be irritating to respiratory tract
Label Elements: Contains warning to avoid ingestion or inhalation, keep out of reach of children
Signal Word: Warning

Composition / Information on Ingredients

Chemical Name: Ergocalciferol
Concentration: 97-100% pure
Impurities: Minimal, trace-level unreacted precursors possible
Stabilizers/Additives: No stabilizing agents commonly added

First Aid Measures

Inhalation: Move to fresh air, monitor for respiratory symptoms, seek medical attention for discomfort
Ingestion: Give water, do not induce vomiting unless directed, monitor for gastrointestinal symptoms
Skin Contact: Wash affected area thoroughly with soap and water
Eye Contact: Rinse immediately with plenty of water for several minutes, consult a physician
Notes to Physician: Treat symptomatically, monitor for elevated calcium levels with substantial ingestion

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray (fog), foam, carbon dioxide, dry chemical powder
Specific Hazards: Product combusts to release carbon monoxide, carbon dioxide, possibly irritating vapors
Protective Equipment: Firefighters require self-contained breathing apparatus (SCBA), standard protective gear
Special Precautions: Avoid inhaling combustion fumes, evacuate area if significant powder involved

Accidental Release Measures

Personal Precautions: Use personal protective equipment, avoid dust formation, ensure adequate ventilation
Environmental Precautions: Prevent entry into drains, sewers, and surface water, contain spillage
Methods for Clean-Up: Gather spilled powder with damp cloth or absorbent materials, place in labeled waste container, clean area with water

Handling and Storage

Handling: Wear lab gloves, goggles, and dust mask, minimize dust generation, practice good hygiene
Storage: Store tightly sealed in a cool, dry place, protect from light and moisture, keep away from incompatible materials (strong oxidizers), maintain standard pharmaceutical storage protocols
Incompatible Products: Oxidizing acids, strong bases

Exposure Controls and Personal Protection

Engineering Controls: Work under local exhaust, handle in well-ventilated area
Personal Protective Equipment: Laboratory coat, safety glasses, chemical-resistant gloves, dust mask or respirator for large spills
Exposure Limits: No established OSHA, NIOSH, or ACGIH exposure limits for Ergocalciferol
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing promptly

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Practically odorless
Melting Point: 115–120°C
Boiling Point: Not applicable (decomposes)
Solubility: Insoluble in water, soluble in ethanol, fats, and oils
pH: Not applicable
Partition Coefficient (log Pow): Approx. 8.8
Vapor Pressure: Negligible at room temperature
Flash Point: Not readily flammable

Stability and Reactivity

Chemical Stability: Stable when stored in original container protected from light, heat, and moisture
Reactivity: No dangerous reactions observed under normal conditions
Hazardous Reactions: Reacts with strong oxidizers, may degrade at elevated temperatures and high humidity
Decomposition Products: Carbon oxides, possible toxic smoke during fire

Toxicological Information

Acute Toxicity: LD50 in rats (oral) reported at 10 mg/kg
Chronic Toxicity: Prolonged high intake leads to hypervitaminosis D and hypercalcemia
Skin/Eye Irritation: Dust may cause mild irritation
Carcinogenicity: Not identified as a carcinogen by IARC, NTP, or OSHA
Reproductive Effects: High doses implicated in developmental toxicity
Sensitization: No evidence of allergenic potential
Symptoms of Exposure: Nausea, dizziness, increased thirst, abdominal pain, confusion with severe overdose

Ecological Information

Ecotoxicity: Not measured to cause adverse aquatic effects at standard levels
Persistence/Degradability: Expected to degrade, no accumulation seen in aquatic food chains
Bioaccumulation: Low potential in realistic release scenarios
Mobility in Soil: Slight, because of low solubility and high log Pow
Other Adverse Effects: Large scale releases may disrupt aquatic calcium balance but are unlikely

Disposal Considerations

Waste Treatment Methods: Dispose via licensed hazardous waste processor
Product Disposal: Dispose of contents/container in accordance with local, regional, national, and international regulations
Unused Material: Collect and send to approved chemical disposal facility
Contaminated Packaging: Rinse thoroughly before recycling or dispose as hazardous material

Transport Information

UN Number: Not regulated
Proper Shipping Name: Not classified as a hazardous material for transport
Transport Hazard Class: Not assigned
Packing Group: Not classified
Limited Quantity Exemption: Usually not restricted in small quantities
Special Precautions: Keep container tightly closed and protected from physical damage and moisture during transport

Regulatory Information

US TSCA Inventory: Listed
OSHA HazCom: Not specifically regulated as a hazardous chemical
EPA SARA Title III: Not listed under Sections 302, 304, 313
EU Classification: Not classified as dangerous according to European Directive 67/548/EEC
Canadian WHMIS: Not controlled
International Inventories: Ingredient reported in relevant regulatory lists for Japan, Australia, China, Korea