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Material Safety Data Sheet: Vitamin B6 (Pyridoxine Hydrochloride)

1. Identification

Product Name: Vitamin B6
Chemical Name: Pyridoxine Hydrochloride
Chemical Formula: C8H11NO3·HCl
Synonyms: Pyridoxine HCl, 3-Hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine hydrochloride, Pyridoxol hydrochloride
CAS Number: 58-56-0
Manufacturer: Refer to the manufacturer’s details printed on the packaging or supplied documentation
Recommended Use: Nutritional supplement in food and pharmaceutical products

2. Hazard Identification

GHS Classification: Not classified as hazardous under GHS
Main Hazards: May cause mild irritation to eyes, skin, and respiratory tract following high or repeated exposures. Large doses may lead to peripheral neuropathy, but the risk is low under normal handling.
Label Elements: None required under GHS.
Precautionary Statements: Avoid dust generation, minimize inhalation, use sensible workplace hygiene practices.

3. Composition / Information on Ingredients

Chemical Identity: Pyridoxine Hydrochloride
Concentration: ≥ 98%
Impurities/Additives: Typical food/pharmaceutical grades have negligible impurities.
Other Ingredients: None relevant for standard supply.

4. First Aid Measures

Inhalation: Move to fresh air, seek medical attention if symptoms persist.
Skin Contact: Wash well with water and soap, remove contaminated clothing.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to manage. Continue rinsing and seek medical care if irritation develops.
Ingestion: Rinse mouth with water, never induce vomiting unless directed by a medical professional, seek medical advice if large amounts are swallowed or if symptoms appear.

5. Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam depending on surroundings.
Specific Hazards: Thermal decomposition may produce hazardous fumes such as nitrogen oxides, hydrogen chloride, and carbon monoxide.
Special Protective Equipment: Responders should wear full protective gear and self-contained breathing apparatus.
Fire Hazards: Dusts may form explosive mixtures with air. Take special care to avoid strong oxidizers.

6. Accidental Release Measures

Personal Precautions: Avoid creating dust; wear personal protective equipment including gloves, dust mask, and goggles if required.
Environmental Precautions: Prevent entry into drains, sewers, or watercourses.
Cleanup Methods: Sweep or vacuum up without creating airborne dust; transfer to suitable containers for disposal. Ventilate area thoroughly.

7. Handling and Storage

Safe Handling: Prevent dust formation, avoid inhalation and contact with eyes or skin. Practice normal industrial hygiene.
Storage Conditions: Store in tightly closed original container in a cool, dry, well-ventilated place away from direct sunlight and moisture.
Incompatible Materials: Strong oxidizing agents.
Specific End Use(s): Always use according to official instructions or industry standards for food/pharma production.

8. Exposure Controls and Personal Protection

Occupational Exposure Limits: No specific workplace exposure limits established.
Engineering Controls: Use adequate ventilation to control dust levels.
Personal Protective Equipment: Safety glasses or goggles, protective gloves, dust respirator if necessary, laboratory coat or suitable workwear.
Hygiene Measures: Wash hands thoroughly after handling, avoid eating, drinking, or smoking in work areas.

9. Physical and Chemical Properties

Appearance: White to almost white crystalline powder
Odor: Practically odorless
pH (5% Solution): 2.3 - 3.5
Melting Point: 205°C (decomposition)
Solubility: Freely soluble in water, slightly soluble in ethanol
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Not applicable
Relative Density: Approx. 1.4 g/cm³
Partition Coefficient (log Pow): -1.20
Flash Point: Not flammable under normal conditions

10. Stability and Reactivity

Stability: Chemically stable under standard conditions of storage and handling.
Reactivity: No hazardous reactions known under normal use.
Conditions to Avoid: Excess heat, light, incompatible substances, moisture.
Hazardous Decomposition Products: Thermal decomposition generates nitrogen oxides, hydrogen chloride, carbon oxides.

11. Toxicological Information

Acute Toxicity: Oral LD50 (rat): > 4000 mg/kg
Chronic Toxicity: Long-term or high-dose intake may affect nervous system (peripheral neuropathy).
Irritation: Mild eye or respiratory irritation may occur at high concentrations.
Carcinogenicity: Not classifiable as to carcinogenicity to humans (no evidence from studies).
Mutagenicity, Teratogenicity, Reproductive Toxicity: No evidence to suggest risk.

12. Ecological Information

Ecotoxicity: Low environmental hazard; not expected to cause adverse effects in aquatic or terrestrial ecosystems at normal release levels.
Persistence and Degradability: Vitamin B6 is biodegradable under environmental conditions.
Bioaccumulation: Unlikely to bioaccumulate.
Mobility in Soil: High water solubility means potential for mobility, but environmental persistence is not significant.
Other Adverse Effects: No notable environmental impact identified at recommended usage levels.

13. Disposal Considerations

Waste Disposal Methods: Dispose of small quantities with normal household waste or via landfill in compliance with local regulations. For bulk disposal, use certified hazardous waste disposal contractors.
Container Disposal: Rinse empty containers, render unusable, and dispose according to local guidelines.
Special Precautions: Avoid uncontrolled release to the environment.

14. Transport Information

UN Number: Not regulated as a hazardous material for transport.
Proper Shipping Name: Vitamin B6, Pyridoxine Hydrochloride
Transport Hazard Class: None
Packing Group: None
Environmental Hazards: None
Special Precautions for User: Standard precautions for transport of powders and nutrients.
Regulatory Notes: Not a marine pollutant, not subject to transport codes such as ADR, RID, IMDG, IATA.

15. Regulatory Information

Classification: Not classified as hazardous under EU Regulation (EC) No 1272/2008.
Inventory Status: Listed in inventories such as TSCA (US), EINECS (EU), DSL/NDSL (Canada), AICS (Australia).
Labeling: No hazard symbol or risk phrases assigned.
Other Regulations: Complies with requirements for food and pharmaceutical additives under FDA and EFSA guidelines when produced and handled correctly.
Workplace Use: Occupational health and safety regulations recommend dust control and personal hygiene to minimize risk.