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West Ujimqin Banner, Xilingol League, Inner Mongolia, China
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Product Name: Vitamin B3
Chemical Name: Nicotinic Acid / Niacin
Synonyms: 3-Pyridinecarboxylic Acid
CAS Number: 59-67-6
Molecular Formula: C6H5NO2
Molecular Weight: 123.11 g/mol
Recommended Use: Nutritional supplement, food fortification, pharmaceutical formulation
Manufacturer/Distributor: Supplied by chemical and nutrition manufacturers
Emergency Contact: Refer to local or regional poison control center or chemical safety office
Classification: Not classified as hazardous under GHS standards
Hazard Statements: May cause mild skin or eye irritation on direct contact; avoid dust inhalation
Signal Word: None generally required
Pictogram: Not required for most uses
Precautionary Statements: Prevent breathing dust; wash thoroughly after handling
Target Organs: Eyes, skin, respiratory tract through direct exposure to dust
Emergency Overview: Solid, colorless or white powder, mild odor, low acute toxicity
Chemical Ingredient: Niacin (Nicotinic Acid)
Purity: Typically ≥ 99% by weight
Impurities: Trace moisture, organic synthesis byproducts (below detection limits in pharmaceutical grade)
Other Components: None, unless formulated as blend with carriers or stabilizers
Ingredient Listings: Major ingredient is always niacin with purity for food or pharma use
Eye Contact: Flush eyes with plenty of water for up to 15 minutes, lifting eyelids; seek medical advice for persistent redness or discomfort
Skin Contact: Wash area thoroughly with soap and water; remove contaminated clothing; seek medical attention if irritation develops or persists
Inhalation: Move to fresh air, support breathing if necessary; seek medical advice if symptoms such as coughing or throat irritation persist
Ingestion: Rinse mouth with water, drink water to dilute; contact poison control for amounts much larger than typical dietary exposure
Other Recommendations: Monitor symptoms in exposed individuals with pre-existing respiratory or allergic conditions
Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide
Unsuitable Media: Avoid high-pressure water streams that disperse dust
Specific Hazards: Organic dust may form explosive mixtures with air; thermal decomposition produces carbon oxides, nitrogen oxides
Protective Equipment: Firefighters require self-contained breathing apparatus, protective gear for toxic fume exposure
Firefighting Procedures: Apply standard firefighting procedures for organic solids, contain runoff to prevent environmental contamination
Combustion Byproducts: Carbon monoxide, carbon dioxide, nitrogen oxides possible during combustion or high heat decomposition
Personal Precautions: Avoid breathing dust; use personal protective equipment including gloves, goggles, dust masks in spill response
Environmental Considerations: Prevent material from entering drains, waterways, or soil; contain spilled powder using physical barriers
Clean-up Methods: Sweep or vacuum up spill, avoid generating unnecessary dust; use wet methods if feasible
Disposal: Place residue in sealed, labeled containers; dispose of according to local regulations
Decontamination: Wash spill area with water after cleanup
Notification: Report significant spills or releases to environmental authorities if required
Handling: Minimize dust formation; avoid contact with eyes, skin, and clothing; use only with adequate ventilation; do not eat, drink, or smoke during use
Safe Practices: Always wear personal protective gear during handling; use local exhaust ventilation or containment to reduce dust exposure
Storage Conditions: Store in cool, dry, well-ventilated area away from heat sources, incompatible chemicals, or direct sunlight; keep container tightly closed
Incompatibilities: Strong oxidizing agents, acids, alkalis, high temperatures
Storage Stability: Shelf-stable under ambient conditions; prevent moisture ingress or exposure to air
Special Precautions: Maintain storage log for pharmaceutical-grade inventory; rotate stock based on expiration dates
Occupational Exposure Limits: No specific limits set by OSHA, NIOSH, or ACGIH for niacin
Engineering Controls: Use local exhaust or general ventilation to keep airborne concentrations below nuisance limits
Personal Protective Equipment (PPE): Safety glasses or goggles, chemical-resistant gloves, long-sleeved work clothing; respiratory protection for dust exposure above threshold
Hygiene Measures: Wash hands and face thoroughly after handling; remove contaminated clothing before entering eating areas
Environmental Controls: Prevent accumulation of dust in work area; install dust collection or suppression systems in processing facilities
Physical State: Solid
Appearance: White or off-white crystalline powder or granules
Odor: Practically odorless
Odor Threshold: Not applicable
pH (5% solution): 3.0 to 4.0
Melting Point: 236 - 239 °C (decomposes)
Solubility in Water: Slightly soluble (21 g/L at 25°C)
Solubility in Other Solvents: Slightly soluble in ethanol; insoluble in ether
Partition Coefficient (log Kow): -0.36
Vapor Pressure: Negligible at room temperature
Density: 1.47 g/cm³
Boiling Point: Decomposes before boiling
Flash Point: Not applicable for solid
Explosive Limits: No data for specific limits, but organic dust hazard present
Evaporation Rate: Not applicable
Chemical Stability: Stable under normal conditions, lab and warehouse storage
Hazardous Reactions: No dangerous polymerization
Incompatible Materials: Strong oxidizers such as peroxides, nitric acid
Conditions to Avoid: Prolonged exposure to elevated heat, humidity, ignition sources
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, oxides of nitrogen under extreme heat or burning
Reactivity: Low under ordinary use; risk increases in dust cloud or contact with strong chemicals
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Oral LD50 (rat) estimated > 4,500 mg/kg; low hazard in typical exposures
Skin Corrosion/Irritation: Mild irritant with prolonged contact
Eye Damage/Irritation: May cause redness or discomfort on direct contact
Respiratory Effects: Mild irritation with inhalation of dust; repeated exposure to airborne dust may aggravate sensitive airways
Sensitization: Not a known sensitizer
Chronic Effects: Chronic overexposure to high doses may cause liver effects, flushing, gastrointestinal upset (mainly with oral intake)
Carcinogenicity: Not classified as a carcinogen by IARC, NTP, or OSHA
Mutagenicity: Not known to cause genetic damage
Reproductive Toxicity: No evidence of adverse reproductive or developmental effects at nutritional doses
Ecotoxicity: No data suggesting substantial aquatic or terrestrial hazard at environmental levels expected from vitamin use
Persistence and Degradability: Readily biodegradable in soil and water; breakdown occurs through microbial activity
Bioaccumulative Potential: Low, based on partition coefficient and water solubility
Mobility in Soil: Mobile in water; unlikely to persist in sediments
Other Adverse Effects: Not expected to disrupt ecosystems at typical disposal or spillage rates
Waste Disposal Methods: Dispose of unused material through licensed waste contractor; landfilling may be permitted for non-hazardous pharmaceutical or nutritional solids
Contaminated Packaging: Rinse empty containers; dispose or recycle as appropriate by local regulation
Environmental Regulations: Follow local and national authority guidelines for pharmaceutical or laboratory chemical disposal; avoid release to natural waterways
UN Number: Not regulated as hazardous material for transport purposes
Proper Shipping Name: Niacin, Vitamin B3
Transport Hazard Class: Not classified as dangerous
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant; not hazardous to air or land transit
Special Precautions: Use sealed containers to prevent spillage or dust during transit; keep cool and dry
Inventory Status: Listed in chemical inventories for EU (EINECS), USA (TSCA), Canada (DSL), Japan (ENCS), Australia (AICS), and others
Labeling Requirements: Pharmaceutical, food, and feed grade subject to purity and labeling standards in most jurisdictions
GHS Classification: Not classified as hazardous; precautionary labeling recommended for industrial quantities
Worker Safety Regulations: Covered by occupational exposure standards for dust or particulates in most countries; compliance with local PPE and ventilation norms required
Environmental Release: Not listed as a toxic chemical for reporting under EPA SARA Title III; subject to best management practices
Food and Pharma Use: Meets regulatory standards (USP, FCC, EP, JP) for human consumption if product is GMP-certified
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
