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Product Name: Vitamin A Palmitate
SYNONYMS: Retinol Palmitate, Retinyl Palmitate
CAS Number: 79-81-2
Recommended Use: Used in food fortification, pharmaceuticals, dietary supplements, cosmetics
Supplier: Information varies by distributor; usually found on packaging label or invoice
Contact Information: Manufacturer emergency phone numbers and addresses available on label or invoice
Emergency Telephone: Details available from supplier
Product Code: Usually batch specific from manufacturer
GHS Classification: Acute oral toxicity (Category 4), Skin irritation (Category 2), Eye irritation (Category 2A), Reproductive toxicity (Category 1B)
Signal Word: Danger
Hazard Statements: Harmful if swallowed, Causes skin and eye irritation, May damage fertility or unborn child
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid ingestion, use protective gear, wash hands frequently, seek medical attention if exposed
Routes of Entry: Inhalation of dust, ingestion, skin absorption, eye contact
Target Organs: Liver, skin, eyes, reproductive system
Health Effects: Acute ingestion can cause headache, nausea, vomiting; chronic exposure associated with bone pain and teratogenicity
Environmental Hazards: Product may accumulate in aquatic environments
Chemical Name: Vitamin A Palmitate
CAS Number: 79-81-2
EC Number: 201-228-5
Concentration: 95-100% active ingredient in typical commercial powders or crystals, diluent and starch may be added for specific preparations
Formulation Additives: Microencapsulation agents (gelatin, sugars), Antioxidants (BHT, tocopherols), Carriers (corn starch) vary by supplier
Inhalation: Move person to fresh air, monitor for respiratory distress, seek medical help if symptoms persist
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, seek medical attention if redness or irritation develops
Eye Contact: Rinse immediately with plenty of clean water for at least 15 minutes, lifting upper and lower eyelids occasionally, seek medical advice promptly
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical attention, give water only if victim is fully conscious
Symptoms: Nausea, vomiting, abdominal pain, headache, skin dryness or cracking, visual disturbances if poisoning is significant
Medical Attention: Medical professionals monitor for signs of vitamin A toxicity and treat symptomatically, supportive therapy as needed
Extinguishing Media: Use dry powder, carbon dioxide, foam, or water spray (not directed stream); avoid high-pressure water jets that can spread material
Specific Hazards: Combustible under fire conditions; decomposes to release irritating fumes and toxic gases such as carbon monoxide and carbon dioxide
Protective Equipment: Firefighters wear full gear including self-contained breathing apparatus
Special Procedures: Move containers from fire zone if safe, keep unaffected containers cool with a water spray, prevent runoff from firefighting from entering drains or watercourses
Personal Precautions: Wear gloves, protective clothing, safety goggles, dust mask if dusting occurs
Environmental Precautions: Prevent product from entering drains, surface water, and soil; contain with dikes as necessary
Cleanup Methods: Sweep or vacuum up (using explosion-proof equipment if possible), avoid raising dust, place in suitable container for disposal
Decontamination: Wash spill area with water and detergent after removal
Disposal: Dispose collected material as hazardous waste according to local regulations
Handling: Handle in well-ventilated area away from incompatible substances such as strong oxidizing agents, minimize dust creation, avoid contact with skin, eyes, and clothing
Hygiene: Wash thoroughly after handling, do not eat, drink, or smoke while using this product
Storage Requirements: Store in tightly sealed containers, keep in a cool, dry place, protect from light, moisture, and air, follow specific temperature recommendations (usually 2-8°C)
Shelf Life: Depends on packaging, typically 12-24 months under recommended conditions, verify with certificate of analysis
Incompatibles: Strong acids, bases, oxidizers
Occupational Exposure Limits: No ACGIH TLV established, supplier may provide recommended occupational exposure limits
Engineering Controls: Use local exhaust ventilation, general room ventilation to minimize airborne dust
Personal Protective Equipment: Gloves resistant to chemicals, safety goggles, lab coat or protective clothing, dust respirator for powder handling
Hand Protection: Nitrile gloves recommended to reduce skin contact risk
Eye Protection: Tight-fitting chemical safety goggles or face shield
Respiratory Protection: NIOSH approved particulate respirator for dusty conditions
Workplace Practices: Emergency shower, eye wash fountain in immediate work area
Appearance: Pale yellow to yellow crystalline powder or oily liquid, characteristic odor
Molecular Formula: C36H60O2
Molecular Weight: 524.86 g/mol
Melting Point: 28-32°C
Boiling Point: Decomposes before boiling
Solubility: Insoluble in water, soluble in fats, oils, ether, chloroform, slightly soluble in ethanol
Density: Approximately 0.9 g/cm³ at 20°C
Flash Point: >110°C (closed cup)
Vapor Pressure: Negligible at ambient temperature
Partition Coefficient (log Kow): High (>8)
Stability: Sensitive to light and oxygen, may degrade upon extended exposure
pH: Not applicable – not water soluble
Chemical Stability: Stable under recommended storage conditions, decomposes with exposure to high heat, strong oxidizers, light, or air
Reactivity: Reacts with strong oxidizing agents, acids, and bases
Hazardous Decomposition Products: Releases carbon oxides, acrid smoke, other hazardous fumes during combustion or decomposition
Polymerization: Not known to occur under normal conditions
Acute Toxicity: LD50 oral (rat): 8,100 mg/kg, LD50 dermal (rabbit): >5,000 mg/kg
Chronic Toxicity: Prolonged excessive intake leads to vitamin A toxicity, with symptoms such as liver enlargement, bone abnormalities, hydrocephalus in infants, skin drying and cracking, increased intracranial pressure
Reproductive Toxicity: Evidence links excessive exposure in pregnancy to birth defects
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA
Routes of Exposure: Ingesting large amounts, inhalation of dust, dermal contact
Symptoms: Nausea, vomiting, headache, irritability, bone pain
Aquatic Toxicity: Low water solubility and mobility, potentially persistent in sediment, risk of accumulation in aquatic organisms
Persistence and Degradability: Slowly degradable in environment if protected from sunlight and oxygen; presence of packaging excipients may alter breakdown rate
Bioaccumulation: Risk due to lipophilic nature indicated by high Kow
Mobility in Soil: Minimal leaching potential due to insolubility in water
Ecotoxicity Data: Limited ecotoxicity studies, but large spills have potential to impact small aquatic environments by altering nutrient loads
Other Adverse Effects: No known significant effects or critical hazards for terrestrial animals at low concentrations
Waste Disposal: Dispose of unused product, contaminated packaging, and spill residue according to local, regional, national, and international regulations
Disposal Methods: Incineration preferred for large volumes, small amounts may go to landfill if in accordance with local guidelines
Avoid Release: Never dispose to sewage system, surface water, or soil
Special Precautions: Empty containers retain product residue, handle and dispose as hazardous waste
UN Number: Not regulated under most transport standards (DOT, IATA, IMDG)
Proper Shipping Name: Not classified as hazardous for transport
Transport Hazard Class: None
Packing Group: None assigned
Special Precautions: Protect from extreme heat, direct sunlight, moisture during transport; prevent container breakage and spillage
Labels: No DOT or GHS labeling typically required for standard commercial shipments
Safety, Health and Environmental Regulations: Listed or exempt in TSCA (USA), EINECS/ELINCS (EU), AICS (Australia), DSL (Canada), ENCS (Japan)
Label Requirements: GHS labeling recommended if packaged for laboratory, chemical supply, or in bulk forms
OSHA Status: Not specifically regulated, but subject to general chemical safety standards
Reproductive Hazard: Flagged for special warning in workplace settings involving possible reproductive toxicity
Food Additive Regulation: Approved for use in food fortification at specified concentrations in many countries, subject to cGMP
State Regulations: California Proposition 65 listing for reproductive risk at high levels, not present at concentrations in standard dietary intake
Other: Users must comply with local, regional, national, and international laws specific to vitamin A palmitate use, handling, and disposal
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
