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Product Name: Tylosin Tartrate
Chemical Family: Macrolide antibiotic
CAS Number: 1405-54-5
Synonyms: Tylosin hydrogen tartrate, Tylosin tartrate salt
Recommended Use: Veterinary antibiotic
Manufacturer Details: Veterinary pharmaceutical manufacturers, contact information available on product packaging
Emergency Contact: Refer to local emergency services or poison control centers for immediate assistance
Hazard Classification: Eye irritation (Category 2A), Respiratory sensitizer (Category 1), Skin sensitizer (Category 1), Specific target organ toxicity with repeated exposure
GHS Label Elements: Hazard pictograms, signal word “Warning,” hazard statements include: causes eye irritation, may cause allergy or asthma symptoms, may cause allergic skin reaction
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Potential Health Effects: May trigger allergic response in sensitive individuals, irritation of eyes, respiratory system, and skin
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, wear protective gloves and eye protection, avoid eating or drinking near the substance
Chemical Name: Tylosin Tartrate
Active Ingredient: Tylosin (as tartrate salt), Macrolide group
Concentration: 90-100% (by weight)
Impurities: Trace residual substances from manufacturing (less than 0.5%)
Molecular Formula: C46H77NO17·C4H6O6
Molecular Weight: Approximately 1149.3 g/mol
Inhalation: Move affected individual to fresh air, seek medical attention if breathing becomes difficult, loosen tight clothing
Skin Contact: Rinse immediately with soap and plenty of water, remove contaminated clothing, seek medical advice for persistent irritation
Eye Contact: Flush eyes cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, obtain medical attention if irritation continues
Ingestion: Rinse mouth with water but do not induce vomiting, seek medical evaluation
Advice for Physicians: Treat symptomatically, monitor for respiratory or allergic reactions
Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Fire Hazards: Decomposes into hazardous fumes including carbon oxides, nitrogen oxides, sulfur oxides when heated to combustion
Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective clothing
Special Procedures: Move containers from fire area if possible without risk, prevent runoff from entering water systems
Personal Precautions: Wear safety goggles, chemical-resistant gloves, dust mask or respirator, and protective clothing to avoid contact
Environmental Precautions: Prevent material from entering sewers, soil, or waterways
Methods for Cleanup: Collect spilled powder with suitable equipment, place in properly labeled containers for disposal, ventilate area thoroughly, avoid generating dust
Decontamination: Wash spill area with soap and water after material pickup
Safe Handling: Work in well-ventilated areas, avoid creating dust, use appropriate protective measures at all times, handle with care, wash hands after handling
Storage Conditions: Keep container tightly closed, store in a cool, dry, well-ventilated location, protect from sunlight, moisture, and incompatible substances like strong oxidizers
Incompatible Materials: Oxidizing agents, strong acids or bases
Storage Temperature: Typically recommended storage at room temperature (15-25°C)
Engineering Controls: Local exhaust ventilation, closed process equipment, or fume hoods
Exposure Limits: No specific occupational exposure limit established; general dust limits (10 mg/m³ total dust, 5 mg/m³ respirable) apply
Personal Protection: Chemical-resistant gloves, lab coat or apron, safety goggles, dust respirator or NIOSH-approved mask
Hygiene Measures: Wash hands, forearms, and face after handling; avoid eating, drinking, or smoking near product
Appearance: White to pale yellow crystalline powder
Odor: Mild, characteristic odor typical to macrolides
pH (1% solution): 5.0–7.5
Solubility: Soluble in water and alcohols
Melting Point/Range: 135–145°C (Decomposition)
Boiling Point: Data not available (decomposes before boiling)
Flash Point: Data not available
Vapor Pressure: Not applicable
Density: Approximately 1.25 g/cm³
Partition Coefficient: Not established
Viscosity: Not applicable
Evaporation Rate: Not applicable
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not considered reactive under normal handling
Hazardous Reactions: Reacts with strong oxidizing agents
Conditions to Avoid: Excess moisture, extreme heat, direct sunlight
Decomposition Products: Carbon oxides, nitrogen oxides, sulfur oxides
Acute Toxicity: Oral LD50 (rat) estimated > 2,000 mg/kg (low toxicity)
Chronic Effects: May sensitize skin and respiratory system, repeated contact can aggravate allergic responses
Carcinogenicity: No human data indicating carcinogenic risk, not listed by IARC, NTP, or OSHA
Mutagenicity: Not considered mutagenic based on available data
Reproductive Toxicity: No evidence of reproductive toxicity in standard tests
Target Organ Effects: Allergic responses may affect skin, eyes, and respiratory system
Other Health Effects: Antibiotic resistance concerns in prolonged exposure
Ecotoxicity: Harmful to aquatic organisms at high concentrations, may contribute to antibiotic resistance in environmental microflora
Persistence and Degradability: Partially biodegradable under some conditions, persistence varies based on soil and water conditions
Bioaccumulation Potential: Expected to have low potential for bioaccumulation
Mobility in Soil: Moderately mobile based on water solubility
Other Adverse Effects: Possible risk of contamination in water systems due to improper disposal or accidental release
Waste Treatment Methods: Incinerate at licensed facility or dispose of through chemical waste program in accordance with local, regional, and national regulations
Packaging Disposal: Rinse containers and dispose of as hazardous waste
Recommended Practices: Do not discharge to septic systems, natural waterways, or open environment; follow all regulations for destruction of pharmaceutical chemicals
UN Number: Not regulated under UN transport codes
Transport Hazard Class: Not classified as hazardous for transportation
Packing Group: Not assigned
Special Precautions for Transport: Avoid high humidity and direct sunlight during transport, transport only in well-sealed containers
Environmental Hazards: Avoid spillage into the environment during loading and movement
US TSCA Status: Not listed
OSHA Hazard Communication: Hazardous as per criteria
EU Regulations: Classified under Regulation (EC) No 1272/2008 (CLP); hazardous symbol(s) and statements required
WHMIS Classification (Canada): D2B–Toxic material causing other toxic effects
Inventory Status: Registered for veterinary use in several countries, varies by region
Labelling: Product label must display safety symbols, risk, and precautionary statements in accordance with local laws
