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Product Name: Toltrazuril
Chemical Name: 1-methyl-3-[3-methyl-4-(trifluoromethyl)phenyl]-1,3,5-triazinane-2,4,6-trione
CAS Number: 69004-03-1
Recommended Use: Veterinary coccidiostat
Manufacturer: Pharmaceutical and chemical producers (inquire for specifics)
Telephone Number for Information: Check with supplier
Emergency Contact: Refer to national poison centers or local emergency contacts
GHS Classification: Acute toxicity (Oral, Category 4), Skin irritation (Category 3)
Label Elements: Signal word: Warning; Hazard Statements: Harmful if swallowed, Causes mild skin irritation
Physical Hazards: Combustible dust can form explosive mixtures with air
Health Hazards: Irritation to eyes, skin, and respiratory tract on exposure, risk increases with prolonged contact
Environmental Hazards: Harmful to aquatic organisms
Chemical Ingredient: Toltrazuril
Concentration: 98–100% pure substance
Impurities: May contain residual solvents and up to 2% unidentified impurities, depending on manufacturer
Molecular Formula: C18H14F3N3O4
Molecular Weight: 425.3 g/mol
Inhalation: Move person to fresh air, monitor breathing, seek medical attention if symptoms persist
Skin Contact: Remove any contaminated clothing, wash affected skin with soap and water for at least 15 minutes
Eye Contact: Flush eyes thoroughly with running water, lifting eyelids often, seek immediate medical care if irritation continues
Ingestion: Rinse mouth, do not induce vomiting, drink water if conscious, seek medical help immediately
Symptoms: May include nausea, vomiting, headache, rash, and respiratory discomfort
Suitable Extinguishing Media: Use foam, dry powder, or carbon dioxide; avoid high-pressure water jets
Unsuitable Extinguishing Media: Do not use high volumes of water due to potential for run-off contamination
Hazardous Combustion Products: Releases toxic fumes including carbon monoxide, oxides of nitrogen, hydrofluoric acid, and hydrogen cyanide
Protection for Firefighters: Wear self-contained breathing apparatus and full protective gear
Special Precautions: Evacuate area, cool down exposed containers with water spray, control run-off
Personal Precautions: Wear gloves, safety goggles, and dust mask; prevent inhalation and skin contact
Environmental Precautions: Prevent product from reaching drains, surface water, and soil
Methods for Cleaning Up: Collect spilled powder using dust-free methods, use absorbent materials, transfer to a tightly sealed waste container
Reference for Cleaning Personnel: Use approved personal protective equipment during cleanup
Safe Handling: Avoid generating dust, do not eat, drink, or smoke in work area, wash hands after use
Technical Measures: Provide local exhaust ventilation, keep work area clean
Storage Conditions: Keep container tightly closed, store in a cool, dry, well-ventilated area out of direct sunlight
Incompatible Materials: Strong oxidizers, acids, or alkalis
Packaging Materials: Store in sealed, appropriately labeled, chemical-resistant containers
Engineering Controls: Use local exhaust ventilation and process enclosures
Exposure Limits: No occupational exposure limits set specifically; use general dust limits (10 mg/m³ total, 5 mg/m³ respirable)
Personal Protective Equipment:
Appearance: White to off-white crystalline powder
Odor: Nearly odorless
Odor Threshold: Not established
pH: 5.5–7.5 (1% solution in water)
Melting Point/Freezing Point: 177–180°C
Boiling Point: Not applicable (decomposes)
Flash Point: Not applicable
Evaporation Rate: Not available
Flammability: Non-flammable under normal handling, dust may be combustible
Vapor Pressure: Not significant
Vapor Density: Not significant
Solubility: Poorly soluble in water (0.36 mg/L at 20°C), soluble in acetone and dimethyl sulfoxide
Partition Coefficient (log Kow): 2.31
Auto-ignition Temperature: No data
Decomposition Temperature: >200°C
Viscosity: Not applicable
Density: 1.46 g/cm³
Chemical Stability: Stable under standard temperatures and pressures, avoids direct sunlight and moisture
Reactivity: Not reactive under normal conditions
Possibility of Hazardous Reactions: None expected when handled properly
Conditions to Avoid: Exposing to strong heating, strong oxidizers, acids, and bases
Incompatible Materials: Strong acids, bases, and oxidizing agents
Hazardous Decomposition Products: Toxic gases—carbon oxides, nitrogen oxides, hydrogen fluoride—on combustion or thermal decomposition
Acute Toxicity: LD50 (oral, rat): 187 mg/kg; mild to moderate toxicity if ingested
Skin Corrosion/Irritation: Low irritation potential seen in animal studies
Serious Eye Damage/Irritation: Mild irritation possible on direct exposure to eye
Respiratory/Skin Sensitization: No significant sensitizing effects observed
Chronic Toxicity: Repeated exposure may affect liver and gastrointestinal tract based on animal data
Carcinogenicity: Not classified as human carcinogen
Mutagenicity/Reproductive Toxicity: Not proven mutagenic or teratogenic; no reliable evidence of risk at levels encountered in veterinary use
Target Organs: Potential impact on liver and digestive tract at high doses
Ecotoxicity: Harmful to aquatic life; fish and daphnia show reduced survival at concentrations above 1 mg/L
Persistence and Degradability: Degrades slowly, can persist in soils and aquatic sediments
Bioaccumulative Potential: Moderate bioaccumulation (log Kow 2.31)
Mobility in Soil: Low water solubility limits mobility, but may leach in porous soils
Other Adverse Effects: Avoid uncontrolled release to waterways and soils used for crops
Methods of Disposal: Dispose as hazardous chemical waste in accordance with local, regional, and national regulations
Contaminated Packaging: Containers must be triple-rinsed and punctured before disposal; comply with authority guidelines
Special Precautions: Do not allow entry into drains, surface water, or soil; incinerate in an approved facility if possible
Waste Codes: Refer to official waste management codes in your jurisdiction
UN Number: Not classified as dangerous for transport under most land and air regulations
Proper Shipping Name: Toltrazuril or chemical name
Transport Hazard Class: No specific hazard class assigned for land, air, or marine
Packing Group: Not assigned
Environmental Hazards: Avoid uncontrolled release during loading and unloading
Special Precautions: Ship in tightly sealed and correctly labeled containers, protect from moisture and sun during transit
Labeling Requirements: Signal phrase “Warning”, hazard and precautionary statements required
Chemical Inventory Status: Registered or exempted under appropriate local and international chemical management systems
Occupational Health: Follow all workplace safety regulations and exposure limits as prescribed by local agencies
Restrictions: Use limited to authorized handlers, not for human consumption
SARA/TSCA/REACH: Review regional chemical compliance registers for inclusion and updates
Other Information: Product to be used only for intended veterinary medicinal use—misuse carries legal and health consequences
