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Toltrazuril: A Comprehensive Commentary

Historical Development of Toltrazuril

Toltrazuril came into focus as a response to a real need in veterinary medicine. During the late twentieth century, livestock producers and veterinarians faced heavy losses from coccidiosis, especially in poultry, pigs, and ruminants. Older drugs fell short against resistant strains. German researchers led the early breakthroughs, drawing on decades of triazine chemistry. By the time toltrazuril entered the market, it offered a new way to protect young animals from gut parasites that stunted growth or caused death. Many livestock vets remember the immediate impact — farm survival rates jumped, and reliance on older, less targeted chemicals started to drop.

Product Overview

Toltrazuril stands out as a coccidiostat. It targets the protozoan parasites of the genus Eimeria. Used mainly in farm animals, especially poultry and piglets, it is often available in oral suspension or powder form, depending on the intended species or farm practices. Companies sell the product under different names. Most farmers know Baycox as one of the leading brand names, produced by Bayer (now part of Elanco). The product’s formulation offers both curative and preventative properties, which helps reduce the frequency of repeated treatments.

Physical & Chemical Properties

Toltrazuril appears as a white to off-white crystalline powder. It does not have a strong odor and is only very slightly soluble in water, which complicates mixing but also prevents it from washing away easily after dosing. Its molecular formula is C18H14F3N3O4S. The compound melts at about 194 to 196°C, and its stability against heat makes it suitable for various preparation methods in the feed industry. Handling the molecule in the lab, one typically notices how stable it is against moderate exposure to light or air, which allows for longer shelf lives in finished products.

Technical Specifications & Labeling

Toltrazuril usually enters the market in strengths that match the animal’s size or needs. For example, oral suspensions often contain 2.5% or 5% toltrazuril, letting farmers tailor the dose without constant recalculation. Labels follow strict regulations in each country: they list concentration, storage guidelines (avoiding moisture, keeping below 30°C), withdrawal times to prevent residues in meat or eggs, and expiry dates. Color-coded caps and clear dosage lines on bottles reduce dosing errors in busy farm settings. Labels also highlight the importance of shaking suspensions before use—something only those who have accidentally poured an unmixed dose can fully appreciate.

Preparation Method

Large-scale production of toltrazuril starts with synthesizing the base triazine ring. Labs then introduce key side chains, including the trifluoromethyl group—a tweak that largely determines the drug’s effectiveness against parasites. The process includes several steps, from condensation reactions to careful crystallization, ensuring maximum purity. Formulation for animal use involves grinding and blending, creating either a suspension in distilled water for direct dosing, or a premix for feed integration. Quality control labs routinely check active content, particle size, and freedom from contaminants or harmful by-products. Years working with animal health companies taught me just how much effort goes into small changes, like using food-grade excipients to prevent caking in storage.

Chemical Reactions & Modifications

Chemical modification work in this area mainly focuses on adjusting side chains to boost absorption or target a broader range of protozoans. Basic toltrazuril resists rapid breakdown, so it remains in the animal’s system long enough to be effective. Newer analogs, such as ponazuril, tweak solubility for different dosing strategies. Some research explores attaching groups that boost bioavailability or minimize environmental residues in manure. Despite hundreds of candidate molecules, the basic structure of toltrazuril continues to offer a strong balance between potency and safety. Trying to fine-tune these molecules often brings scientists into a tug-of-war between improving action and keeping day-to-day farm practicality.

Synonyms & Product Names

Though scientists and veterinarians use the name toltrazuril, commercial products might use names like Baycox, Tolcox, Intracox, or Toltracox. Each product keeps the same core active ingredient: toltrazuril. Regulatory submissions list its CAS number: 69004-03-1. The molecular structure sometimes appears as 1,3,5-Triazin-2(1H)-one, 3-[3-methyl-4-(trifluoromethyl)phenyl]-2-[(4-methylphenyl)sulfonyl]-. Branding choices depend on the region, the company, and which species the product aims at. That said, ask any farm vet, and “Baycox” usually conjures a quick mental image and years of treatment routines.

Safety & Operational Standards

Ensuring safety takes center stage in veterinary chemicals. Toltrazuril earned approvals based on full dossiers: data on administration, elimination, tissue residues, and risks to farm staff. Proper storage and use keep doses away from children and untrained workers. Field reports rarely mention human accidents, but all medicines pose risks, so gloves and eye protection are standard. Used correctly, toltrazuril rarely causes side effects in target animals. The main red flag crops up with overdoses—something that happens when staff skip training on correct dilution. Regulatory bodies recommend withdrawal periods after the last treatment before meat or eggs from treated animals enter the food chain. In years working with animal health audit teams, I saw just how carefully farms log each treatment, mainly out of respect for food safety and fear of losing market access.

Application Area

Veterinarians use toltrazuril mostly to manage coccidiosis in chickens, turkeys, pigs, cattle, sheep, and, sometimes, companion animals like rabbits. In broiler farms, it stops gut infection during the most dangerous early weeks of life. Pig producers find it essential for piglet health, where infection can rob each animal of weeks’ worth of growth. Some zoos and specialty breeders depend on it for species exposed to stress or poor sanitation. Toltrazuril’s appeal is high activity with a single dose or short course, as opposed to the week-long regimens older products require. In practice, the drug shifted animal care routines—less time spent on sick pens, more predictable growth, and far fewer deaths.

Research & Development Efforts

Academic labs and pharmaceutical research teams remain invested in improving toltrazuril and its relatives. Some projects try to better understand how the drug interrupts the complex Eimeria life cycle, hoping to design next-generation treatments. Pharmacokinetic studies compare single oral doses with extended-release strategies. Recent work highlights the environmental impact of residues—scientists track how unmetabolized toltrazuril passes into manure, then into soil, and what risks this poses to aquatic life. Companies run trials to gauge resistance trends and tune recommendations to delay loss of drug potency. It’s common knowledge in the field that every time a group discovers a more effective way to block parasite lifecycles, animal welfare improves, and food producers benefit.

Toxicity Research

Toxicity studies underpin all veterinary product approvals. Toltrazuril demonstrated low toxicity for target animals at standard doses, and researchers ran studies on acute, sub-chronic, and long-term exposure. Most species handle the chemical well. Occasional animal studies, especially on birds and rodents, probed for rare signs of reproductive issues, cancer, or neurological harm, and found little cause for alarm at recommended doses. Researchers looked for tissue residues to set withdrawal periods—time needed for the drug to naturally disappear before slaughter or egg collection. Environmental safety reviews continue, with trace amounts raising concerns about aquatic organisms in fields regularly fertilized with manure. In years spent reporting field results, I heard about rare mishaps from misunderstood mixing ratios—not from the drug itself.

Future Prospects

Toltrazuril faces several crossroads. On one side, demands for safer, more sustainable therapies drive researchers to tweak the drug for higher effectiveness at lower doses, or to combine it with vaccines or other drugs. Public pressure grows to cut pharmaceutical use on farms, inspired by concerns about residues and unintended impacts on water or wildlife. Each new regulation asks for better monitoring and cleanup. On the positive side, the story of toltrazuril stands as proof that careful science lifts animal health and food security. Next steps in development likely follow the model of making drugs that leave fewer residues, resist resistance, and stay easy for farmers to administer. It’s a future shaped by hands-on experience—scraping waterers, dosing restless animals, penciling numbers on barn walls—alongside advances in chemistry and biology.




What is Toltrazuril used for?

Treating More Than Symptoms

In the world of livestock and hobby farming, intestinal parasites are more than just a headache. Coccidiosis, a disease brought on by protozoan parasites, can wipe out entire flocks or herds if left unchecked. Toltrazuril isn’t a household name, but in my years of caring for young animals—especially poultry, rabbits, and lambs—I’ve watched this treatment make the difference between failure and healthy growth.

Fighting Invisible Enemies

Coccidia are tricky; you don’t see them. What you see is sick animals—off feed, droopy, sometimes with bloody droppings. Stress, dirt, and crowding make things worse. For years, people relied on older drugs like sulfa-based medications, but these have their limits and sometimes fail to stop repeat outbreaks. Toltrazuril gives a broader approach. It does not just ease the signs. It targets the lifecycle of the parasite inside the gut, stopping them before they destroy intestinal tissue.

Making a Visible Impact on Farms

I have seen flocks of chicks, slumped in corners, regain energy a day or two after a dose. Losing whole batches of rabbits to diarrhea hurts both money and morale. Toltrazuril arrived as a game-changer for backyard keepers and professionals alike. Studies show massive drops in coccidia oocyst counts after treatment—sometimes more than 90% reduction. Survivability improves, feed efficiency improves, and future reproductive performance is stronger. In veterinary circles, many turn to toltrazuril as a go-to option, especially where resistance to old drugs has popped up.

Risks and Responsibilities

Toltrazuril isn’t a miracle cure-all. Used carelessly or too often, drugs in any industry lose their punch. I cringe when folks dump treatments into water without weighing animals or tracking doses. Overuse may breed tougher, resistant parasites. Animal welfare, food safety, and environmental health all depend on careful, knowledgeable use of products. For food animals, strict withdrawal periods matter. Drug residues in meat, milk, or eggs can hurt consumers—it’s a responsibility that sits squarely on the producer's shoulders.

Better Outcomes Start With Good Practices

Addressing coccidiosis or any livestock disease shouldn’t start and end with a bottle. Clean housing, clean water, and low-stress environments remain cornerstones of health. Toltrazuril works best as part of a bigger effort, not a replacement for normal hygiene. I remind people that prevention—using good management and regular monitoring—means fewer outbreaks and less need for medication all around.

Looking Ahead

Demand for toltrazuril reflects a desire for healthier, happier animals, and fewer economic losses. Researchers keep watch for resistance, new strains of parasites, and best treatment approaches. Veterinarians play a vital role, offering science-based advice. Those raising animals—whether for a living or love of the process—benefit from understanding both the power and the limitations of what’s in their medicine cabinet. Toltrazuril is one tool, but using it well means farming and animal care move toward greater quality and responsibility.

How is Toltrazuril administered?

What Toltrazuril Does for Animals

Farmers know all too well how coccidiosis can wipe out a young flock or litter. This intestinal disease strikes fast, and some animals just don’t bounce back. Toltrazuril steps in as a lifesaver for young livestock and pets, tackling coccidia before they ruin an animal’s gut. With rising food demands, keeping animals healthy matters as much as having enough land to graze them on. Toltrazuril has earned trust because it clears the bugs before real harm kicks in.

Giving Toltrazuril: How the Medicine Reaches Animals

Cattle, sheep, goats, pigs, chickens, rabbits, and even puppies and kittens may get toltrazuril. Different species call for their own dosing, but the goal never changes: keep coccidia from running wild. Oral doses stand out as the main method. On livestock farms, toltrazuril usually comes in a liquid form. Caregivers use a dosing gun or syringe, measure by weight, and deliver it straight by mouth. Trying to mix medicine in feed can leave the weakest animals behind, because the bold ones hog the food and the rest get cheated out of their share.

Poultry producers often add toltrazuril to drinking water. That way, chicks pick up just enough as they stay hydrated. This approach avoids the struggle of catching every bird. Still, close watching makes the difference because sick animals often drink less and might miss their dose. In practice, catching problems early improves the odds. Waiting too long lets disease get ahead.

Weight, Timing, and Risks: Why Getting It Right Matters

Many folks count on guidelines printed on labels, but real-world conditions—think growing piglets or lambs that outpace their age-group—call for common sense. Overdosing can hit the liver or kidneys hard, but skimping out brings no protection. Recent studies show the drug clears out of the animal pretty fast, but residues concern both meat producers and people who eat the meat. Withdrawal times exist for a reason, and they deserve respect from everyone along the supply chain. The risk of resistance keeps veterinarians on their toes. As with any tool, misuse chips away at future effectiveness.

What Experience Teaches About Toltrazuril

Veterinarians and experienced farmers know timing wins battles against coccidiosis. Treating every new batch of young animals, rather than waiting till diarrhea or weight loss shows up, guards not just that group but the next. It’s tempting to hold off and see if problems clear up. More often, waiting costs more—lost growth, extra treatment, even deaths that could’ve been avoided.

Responsible Use: Solutions and Steps Forward

Clear record-keeping helps farmers keep track of which animals received what, and when. That habit keeps withdrawal times straight and prevents confusion if animals get sick later. Teaching staff proper dosing saves time and money and avoids trouble with overdosing or underdosing. Sharing stories and lessons at community meetings or industry workshops spreads tricks that paperwork alone never covers. More attention from veterinarians, better communication with farm staff, and listening to food safety scientists will shape the next few years. These steps leave room for healthy animals and safe food—which benefits us all, not just the people living on farms.

What are the side effects of Toltrazuril?

Understanding Toltrazuril and Its Use

Toltrazuril belongs to the family of drugs known as coccidiostats. Veterinarians reach for this medication often, especially when treating coccidiosis in animals like chickens, pigs, lambs, and sometimes even pet birds. Coccidia thrive in crowded animal environments, so managers of farms and shelters rely on medicines like toltrazuril to defend their stocks. Still, no medicine comes with zero risks.

Common Side Effects Observed in Real Life

Most animals tolerate toltrazuril pretty well, but small issues do pop up now and then. Loose stools or mild digestive upset show up first for many. I remember talking to a poultry farmer who’d notice that some chicks treated with toltrazuril passed softer droppings for a couple of days. It's not exactly pleasant for the caretaker, but in most cases, the droppings returned to normal without extra intervention. Sometimes you see a little tiredness, perhaps a drop in appetite. For lambs and calves, less energy or slower feeding has prompted some producers to reduce doses or watch hydration more closely.

Serious Risks: Are They Real?

The risks look low from most reports, but no product deserves blind trust. In rare cases, animals get an allergic response—swelling around the face or trouble breathing. These cases might pop up in animals with odd sensitivities or in herds where previous medications stacked up in their system. Research suggests toltrazuril doesn’t seem to harm major organs if given at proper doses for the right duration. European studies on swine and cattle note that excess doses rarely do extra harm, but prolonged use—especially at high concentrations—still poses risks. Liver workload picks up, and a weak animal might tip over from it. Vets sometimes spot trace elevations in liver enzymes after prolonged toltrazuril rounds, though the signs stay mild unless the animal already struggles with health issues.

Why Monitoring Matters

Every medicine causes its set of trade-offs. Toltrazuril lets producers save animals from deadly illness but also calls for steady observation. Large operations should keep logs; track which batches got treated, note side effects, and compare against untreated groups. This attention let’s us catch odd reactions early. In my work with livestock, we paid close attention during the days following treatment—logging every odd behavior. That habit caught small problems before they grew large. Knowing the animal’s health going in matters just as much. Stressed, sickly, or very young animals might react differently than robust ones. Adjustments based on age, weight, and stress level could spare headaches later.

Alternative Approaches and Responsible Use

Medicine works best as part of a toolkit, not as a crutch. Clean bedding and low crowding prevent heavy parasite loads in the first place. Mixed with good nutrition and hygiene, toltrazuril does its best work. Producers who rotate pastures and clean pens often see fewer outbreaks and need less medication overall. For pet owners, talking to a vet first gives the needed clarity on doses, chances for reactions, and any special precautions. Some pet birds and exotic species don't process the medicine in the same way as livestock—it isn’t just about size, but species metabolism too.

Making Informed Decisions

Farmers, pet owners, and veterinarians know that treating disease comes with tough choices. Toltrazuril has earned its place for treating coccidiosis but deserves careful management. Sharp observation, dose control, and support through nutrition and hygiene turn it into a valuable ally. Responsible use guided by experience and veterinary advice helps keep animals healthy and protected from drug-related setbacks.

Is Toltrazuril safe for all animals?

Understanding How Toltrazuril Works

Toltrazuril usually comes up when someone needs to tackle coccidiosis in animals, especially livestock and poultry. It targets protozoan parasites that invade the gut and can make young animals lose appetite, struggle to gain weight, or even die if left untreated. Modern farms often rely on strong medicines to keep animals healthy and productive, but it's easy to glance past the fine print and forget no drug fits every creature perfectly.

Looking at the Facts

Veterinarians and researchers have studied toltrazuril a lot with animals like chickens, pigs, and rabbits. Sheep and cattle benefit too. On these farms, the medicine can help a lot during outbreaks. A sheep farm I once visited dealt with nearly half its lambs sickened by diarrhea and blood in their stools one spring. After the vet prescribed toltrazuril—at precise doses and under strict watch—the losses dropped, and lambs perked up. Without drugs like these, some herds wouldn’t even break even.

Still, the way toltrazuril acts in each animal is different. Chickens process the drug much faster than lambs do. Some breeds have more sensitive livers. A goat’s metabolism veers from cows, which means side effects can pop up if a farmer guesses on dose. Puppies and kittens have been treated off-label in recent years, but research here looks thinner. Too much toltrazuril for a young dog could harm organs, and cats may react poorly if given doses designed for other animals.

Why It Matters to Know the Risks

People who care for animals—whether backyard hobbyists or large-scale producers—don’t always realize that medicines like toltrazuril have narrow safety margins. Underdosing just won’t solve the parasite problem, but using the wrong amount or giving it to the wrong species leads to real harm. The kidneys clear out toltrazuril at a certain rate, so if an animal's liver or kidneys don’t work well, toxic buildup creeps in. A vet in our area once saw a group of rabbits poisoned after toltrazuril mixed into their water bowl at a guess. Some survived only with extra fluids and a lot of attention.

Sometimes, the urgency to fix a parasite outbreak makes people cut corners. There’s still a temptation to share leftover doses between species. But each label is there because hard-earned data shaped it. Veterinary science, like all science, moves step by step, not in leaps. One study in the Journal of Veterinary Pharmacology and Therapeutics found an adverse reaction rate under 2% in sheep at approved doses, but tripling the dose ramped up trouble fast: lethargy, loss of appetite, even liver injury in a few.

A Smarter Way Forward

Education stands out as a real fix. Clearer product labels would help everyday animal keepers steer away from trouble. Veterinaries who take time to run quick health checks before prescribing can catch risks early, especially in pets or odd cases. Producers should keep up with withdrawal times in farmed animals, since residues in meat or milk could affect people. Nothing replaces open talk between vets and animal caretakers—catching concerns before mistakes happen saves lives, both animal and human.

Toltrazuril works as an important tool, but only in the right hands, for the right animal, and at the right dose. Respecting that difference makes all the difference, far beyond the farm fence.

What is the recommended dosage of Toltrazuril?

Why Toltrazuril Matters in Animal Care

For folks who care for livestock or companion animals, few things hit harder than a bad run-in with coccidiosis. Anyone who’s seen a calf, piglet, or foal waste away from this parasite knows the frustration and urgency that surround treatment. Toltrazuril isn't some miracle cure, but it does give you the upper hand. Access to reliable dosing information can make all the difference between a quick recovery and weeks of setbacks.

Dosage Recommendations in Simple Terms

Veterinarians and livestock managers often follow the 20 mg per kg rule for most young animals. For horses and poultry, the dosage sits in that same ballpark, though it's smart to double-check label guides for each species. If you’re treating piglets, 20 mg/kg given once, usually by mouth, does the trick. Foals land around 20 mg/kg per day, split over two days. Poultry typically receive about 7 mg/kg for two days straight. Every animal type faces its own risk level and absorption rate, and that's why sticking to species-specific amounts keeps both the animals and your investment safe.

Expertise and Safety: Not Just Numbers

It’s tempting to measure out a generic dose and move on, especially during a busy calving season. I’ve seen more than one farmhand use a “close enough” method, only to be caught off guard by lingering illness. Overdosing brings its own problems — from stress on the gut to potential for drug residues in food animals. On the other hand, skimping on the amount lets the parasites dig in deeper. Decades’ worth of clinical studies guide current recommendations for Toltrazuril use. Most coccidiosis outbreaks get under control when people stick to published doses, so you won’t hear many practicing vets recommending off-label guesstimates.

Risks of Relying on Guesswork

The biggest danger lies in assuming “more is better.” Toltrazuril carries withdrawal times, meaning you need to wait a certain period between dosing and slaughter or milking. This isn’t red tape for the sake of paperwork—drug residues can end up in meat or milk if these windows aren’t followed. Smart producers post dosing and withdrawal charts in plain sight of anyone who handles medicating chores. It avoids accidents and builds consumer trust.

Practical Solutions for Better Outcomes

A veterinarian is your go-to source for correcting any gaps in knowledge. Digital apps and dosing calculators can help remove guesswork, but they can’t replace supervision. Real prevention starts in management: keeping pens dry, feeding clean, separating sick animals, and treating only the ones who need it. Conversation between farm workers and veterinarians lowers stress and boosts survival rates. In my own experience, open communication on these topics keeps problems small and solutions faster.

The Bottom Line with Toltrazuril

Medicine isn’t magic. Following the days of a precise Toltrazuril schedule, I’ve seen barns return to their bustling, healthy selves. Trusted sources — label instructions and veterinarians — aren’t there to slow things down, but to protect livelihoods and animal welfare. Sticking with recommended dosages means fewer surprises for everyone involved, animal or human.

Toltrazuril
Names
Preferred IUPAC name 1-methyl-3-[3-methyl-4-[4-(trifluoromethylthio)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione
Other names Baycox
Tolzural
Toltracox
Tolzuril
Pronunciation /ˌtɒl.trəˈzjuː.rɪl/
Preferred IUPAC name 1-methyl-3-[3-methyl-4-[4-(trifluoromethylthio)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione
Other names Baycox
Tolcox
Toltrazuril 2.5%
Toltrazuril 5%
Toltrazuril Solution
Pronunciation /tɒlˈtræz.jʊ.rɪl/
Identifiers
CAS Number 69004-03-1
3D model (JSmol) `3D model (JSmol)` string for **Toltrazuril**: ``` CC1=NC2=C(N1C3=CC=CC=C3)SC(S2)=O ``` This is the SMILES string version for use in 3D JSmol modeling tools.
Beilstein Reference 5642840
ChEBI CHEBI:72564
ChEMBL CHEMBL230945
ChemSpider 215451
DrugBank DB01194
ECHA InfoCard 21c65f51-0f36-4e40-ae87-36eac9ad6ecc
Gmelin Reference 108792
KEGG D06034
MeSH D000066271
PubChem CID 71300
RTECS number UY4378000
UNII 1W1URQ04KU
UN number UN3077
CAS Number 69004-03-1
Beilstein Reference 3648731
ChEBI CHEBI:72564
ChEMBL CHEMBL190901
ChemSpider 28521
DrugBank DB11258
ECHA InfoCard EC Number 403-640-2
EC Number EC 3.4.4.2
Gmelin Reference 88901
KEGG D06053
MeSH D000069550
PubChem CID 71300
RTECS number XS8770000
UNII 27RVX9Z5G3
UN number UN3077
Properties
Chemical formula C18H14F3N3O4S
Molar mass 425.418 g/mol
Appearance Colorless to yellowish liquid
Odor Odorless
Density 1.34 g/cm³
Solubility in water Slightly soluble
log P 2.75
Vapor pressure 4.2 × 10⁻⁹ mmHg (25 °C)
Acidity (pKa) 13.95
Basicity (pKb) 8.55
Refractive index (nD) 1.642
Viscosity Viscous liquid
Dipole moment 5.77 D
Chemical formula C18H14F3N3O4S
Molar mass 425.4 g/mol
Appearance A clear, colourless to brownish yellow solution
Odor Odorless
Density 1.34 g/cm³
Solubility in water Practically insoluble in water
log P 2.45
Vapor pressure <0.0000001 mmHg (20 °C)
Acidity (pKa) 13.87
Basicity (pKb) 14.44
Magnetic susceptibility (χ) Diamagnetic
Refractive index (nD) 1.642
Viscosity Viscosity: 3.9 mm²/s (20°C)
Dipole moment 3.61 D
Thermochemistry
Std enthalpy of formation (ΔfH⦵298) -672.4 kJ/mol
Std enthalpy of formation (ΔfH⦵298) -870.4 kJ/mol
Pharmacology
ATC code P51AX08
ATC code P51AX08
Hazards
Main hazards May cause eye irritation. Harmful if swallowed. May cause respiratory irritation.
GHS labelling GHS labelling of Toltrazuril: "Warning; H302: Harmful if swallowed; H373: May cause damage to organs through prolonged or repeated exposure; P264, P270, P301+P312, P314, P501
Pictograms GHS07
Signal word Warning
Hazard statements H302: Harmful if swallowed.
Precautionary statements Keep out of reach of children. Avoid contact with skin, eyes, and clothing. Do not inhale vapour or mist. Wash hands thoroughly after handling. If swallowed, seek medical advice immediately and show the container or label.
NFPA 704 (fire diamond) Health: 1, Flammability: 1, Instability: 0, Special: -
Flash point > 181.5 °C
Autoignition temperature 323 °C
Lethal dose or concentration LD50 (oral, rat) > 2000 mg/kg
LD50 (median dose) LD50 (median dose) of Toltrazuril: "≥2000 mg/kg (oral, rat)
PEL (Permissible) PEL (Permissible Exposure Limit) for Toltrazuril is not established.
REL (Recommended) 10 mg/kg
IDLH (Immediate danger) No IDLH established
Main hazards May cause eye irritation; harmful if swallowed; may cause damage to organs through prolonged or repeated exposure.
GHS labelling GHS labelling of Toltrazuril: "Warning; H302, H410; P264, P270, P273, P301+P312, P330, P391, P501; Exclamation mark, Environment
Pictograms GHS07
Signal word Warning
Hazard statements H302: Harmful if swallowed.
Precautionary statements P102 Keep out of reach of children. P273 Avoid release to the environment. P314 Get medical advice/attention if you feel unwell. P501 Dispose of contents/container in accordance with local regulations.
Flash point 163.1°C
Lethal dose or concentration LD50 (oral, rat): > 2000 mg/kg
LD50 (median dose) 2000 mg/kg
NIOSH Not Established
PEL (Permissible) PEL (Permissible Exposure Limit) for Toltrazuril is not officially established by OSHA, NIOSH, or ACGIH.
REL (Recommended) 10 mg/kg
IDLH (Immediate danger) Not established
Related compounds
Related compounds Diclazuril
Clazuril
Ponazuril
Related compounds Diclazuril
Clazuril
Ponazuril