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Chemical Name: Tilmicosin Phosphate
CAS Number: 137330-13-3
Synonyms: Tilmicosin Hydrogen Phosphate, Pulmotil
Product Use: Veterinary antibiotic, treatment of bovine respiratory disease
Supplier: Manufacturer’s full name, address, emergency phone number provided on product label
Recommended Restrictions: Only for approved veterinary applications
Classification: Acute Toxicity (Oral) – Category 2, Specific Target Organ Toxicity (Repeated Exposure) – Category 2
Signal Word: Danger
Hazard Statements: Fatal if swallowed; may damage heart and other organs through prolonged or repeated exposure
Pictograms: Skull and crossbones, exclamation mark
Routes of Exposure: Oral, dermal, inhalation
Precautionary Statements: Avoid contact with skin and eyes, use only outdoors or in a well-ventilated area, do not eat/drink/smoke when using this product, keep out of reach of children
Active Ingredient: Tilmicosin Phosphate
Chemical Formula: C46H80N2O13·xH3PO4
Concentration: 98% or as specified on product label
Other Components: May include stabilizers and water (trace amounts)
Impurities: Less than 1%, not considered hazardous at these concentrations
Inhalation: Move person to fresh air. Seek medical attention for persistent symptoms.
Skin Contact: Remove contaminated clothing. Wash thoroughly with soap and water.
Eye Contact: Rinse with clean water for 15 minutes, keep eyelids open, seek medical attention.
Ingestion: Rinse mouth, do not induce vomiting, get immediate medical attention
Most Important Symptoms: Cardiotoxic effects, dizziness, vomiting, abdominal pain, rapid heartbeat
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray
Unsuitable Media: Direct water jets
Special Protective Equipment: Firefighters use self-contained breathing apparatus and full protective clothing
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, phosphorous oxides, toxic fumes
Advice for Firefighters: Remove containers from area if safe, avoid breathing vapors, cool containers with water spray
Personal Precautions: Wear protective gloves, goggles, and suitable respirator
Methods for Cleaning Up: Absorb spill with inert material, collect into closable containers, avoid dust formation
Environmental Precautions: Prevent entry into waterways, drains, soil
Reference to Other Sections: Refer to exposure controls and disposal considerations for further guidance
Decontamination: Wash affected area with water and detergent, ventilate area
Handling: Avoid contact with skin or eyes, minimize dust generation, handle in well-ventilated area, hygienic practices encouraged
Storage: Store in tightly closed original container, cool, dry place, away from incompatible materials such as strong oxidizing agents
Incompatibility: Reactive with strong bases and acids, avoid heat and open flame
Specific Uses: Observe labeling for animal treatment instructions
Control Parameters: Occupational Exposure Limit not established for tilmicosin phosphate
Engineering Controls: Use adequate ventilation, exhaust at point of generation
Eye Protection: Safety goggles, face shield if dust present
Skin Protection: Chemical-resistant gloves, long sleeves
Respiratory Protection: Use approved respirator for dust or particles if limits might be exceeded
General Hygiene: Wash hands after handling, avoid eating or drinking while handling product
Appearance: Off-white to yellow crystalline powder
Odor: Faint, characteristic
Odor Threshold: Not available
pH: 3.0–5.0 (1% solution)
Melting Point/Freezing Point: 183–187°C
Boiling Point: Decomposes before boiling
Flash Point: Not flammable
Solubility: Water soluble
Vapor Density: Not applicable
Partition Coefficient (n-octanol/water): Not available
Stability: Stable under recommended storage conditions
Chemical Stability: Stable under normal temperatures and pressures
Reactivity: No known dangerous reactions under normal conditions
Possibility of Hazardous Reactions: Contact with strong acids/bases may lead to decomposition
Conditions to Avoid: Heat, flame, moisture, prolonged exposure to light
Incompatible Materials: Strong oxidants, strong acids
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, phosphorous oxides
Acute Toxicity: LD50 (oral, rat) 50–100 mg/kg
Routes of Exposure: Ingestion, inhalation, skin, eyes
Symptoms: Nausea, vomiting, abdominal pain, rapid heart rate, headache
Chronic Effects: Prolonged exposure may damage organs, especially cardiac muscle
Carcinogenicity: Not classified as a carcinogen by IARC, NTP, OSHA
Mutagenicity: No evidence in standard tests
Reproductive Toxicity: Data insufficient for conclusion; caution advised
Ecotoxicity: Toxic to aquatic organisms
Persistence and Degradability: Slowly biodegradable in soil and water
Bioaccumulative Potential: Low potential for bioaccumulation in aquatic life
Mobility in Soil: Moderate mobility
Other Adverse Effects: Avoid direct release into environment, large spills may affect beneficial microorganisms
Product Disposal: Dispose of contents/container in accordance with local and national laws
Contaminated Packaging: Triple rinse and offer for recycling or reconditioning where permitted
Special Precautions: Do not dispose of in household garbage or sewer
Hazardous Waste Code: Not classified as hazardous waste in many regions, but verify local requirements
UN Number: Not regulated under UN, ADR, IATA, IMDG for small quantities
Proper Shipping Name: Tilmicosin Phosphate
Hazard Class: Not classified
Packing Group: Not assigned
Environmental Hazards: Not considered marine pollutant per IMDG
Special Precautions: Handle with care; secure packaging to avoid leaks
Federal/International Regulations: Subject to regulation under US EPA (TSCA, FIFRA), EU REACH, and other bodies for drug and veterinary product approval
OSHA Status: Hazardous chemical under OSHA Hazard Communication Standard
State Regulations: Listed under various state right-to-know laws (consult specific state regulation)
Inventory Status: Listed on major national inventories (TSCA, DSL, EINECS)
Other Requirements: Keep detailed records of storage, usage, and disposal as required by regulatory authorities
