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Product Name: Thyroxine
Chemical Name: L-3,5,3',5'-tetraiodothyronine
Synonyms: T4, Levothyroxine
CAS Number: 51-48-9
Molecular Formula: C15H11I4NO4
Molecular Weight: 776.87 g/mol
Recommended Use: Hormone replacement, research, pharmaceutical use
Supplier/Manufacturer Information: Provided on packaging or request
Emergency Contact Number: See local or supplier emergency documentation
GHS Classification: Acute toxicity, Category 4 (oral); Specific target organ toxicity, repeated exposure, Category 2
Signal Word: Warning
Hazard Statements: Harmful if swallowed. May cause damage to organs through prolonged or repeated exposure.
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid breathing dust. Wash hands thoroughly after handling. Do not eat, drink, or smoke when using this product.
Possible Health Effects: Irritation to gastrointestinal tract. Potential symptoms include headache, nervousness, sweating, weight loss, and palpitations in case of overdose.
Other Hazards: Not classified as an environmental hazard, but should be handled and disposed of properly to avoid contamination.
Thyroxine (L-3,5,3',5'-tetraiodothyronine): >98% by weight
Other Ingredients: May contain trace impurities and stabilizers; dependent on manufacturer extraction/purification process.
CAS Number: 51-48-9
Contaminants: Not expected under normal handling, always verify with supplier COA (Certificate of Analysis).
Inhalation: Move affected person to fresh air. Consult a physician for guidance if respiratory symptoms develop.
Ingestion: Rinse mouth with water. Do not induce vomiting. Seek immediate medical attention.
Skin Contact: Wash affected area thoroughly with soap and water. Remove contaminated clothing.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes. Seek medical advice.
Important Symptoms: Thyroid hormone overdose can include restlessness, muscle weakness, fever, angina-like pain, confusion, or heart rhythm disturbances.
Medical Attention/Special Treatment: Treat symptomatically and provide supportive measures as appropriate to thyroid hormone toxicity.
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam.
Unsuitable Media: Avoid using water jets as they may spread the material.
Specific Hazards: Carbon oxides, nitrogen oxides, hydrogen iodide gas may be released under fire conditions; toxic fumes possible.
Protective Equipment: Wear self-contained breathing apparatus (SCBA) and full protective gear for firefighters.
Fire/Explosion Risk: Not considered flammable under normal circumstances, but intense heat can cause decomposition.
Fire-Fighting Procedures: Move containers away from fire area if safe, cool containers exposed to heat.
Personal Precautions: Avoid breathing dust. Use appropriate personal protective equipment (PPE) including gloves, lab coat, and eye protection.
Environmental Precautions: Avoid release to the environment as a precautionary measure. Prevent further leakage if safe.
Methods for Cleanup: Sweep up and place in a suitable container for disposal. Wash spill area with soap and water. Do not allow runoff into drains or water sources.
Response Actions: Notify responsible authorities if spill cannot be contained or if environmental contamination has occurred.
Safe Handling: Avoid contact with skin, eyes, and clothing. Handle in well-ventilated area. Do not eat, drink, or smoke while handling material.
Storage Conditions: Store at room temperature or as specified by supplier. Protect from light, moisture, and incompatible materials.
Storage Containers: Use original packaging or suitable containers tightly closed and clearly labeled.
Incompatibilities: Strong oxidizers, acids, or bases may react with product under certain conditions.
Specific Practices: Ensure strict lab procedures for accountability, especially in pharmaceutical or chemical research contexts.
Occupational Exposure Limits: No established OSHA, ACGIH, or NIOSH limits; minimize exposure by good laboratory practices.
Engineering Controls: Use laboratory fume hood or local exhaust ventilation.
Personal Protective Equipment: Chemical-resistant gloves, safety goggles or face shield, protective lab coat. Respiratory protection recommended if dust or aerosols form.
Hygiene Practices: Wash hands after handling. Prevent exposure beyond laboratory or industrial setting.
Monitoring: Environmental and biological monitoring recommended in high-volume facilities or where risk of chronic exposure exists.
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Not determined for solid; slight acidity in solution
Melting Point: Approximately 235°C (decomposes)
Boiling Point: Not available (decomposes before boiling)
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Not classified as flammable
Vapor Pressure: Negligible at ambient conditions
Vapor Density: Not applicable
Solubility: Slightly soluble in water; more soluble in dilute alkaline solutions and ethanol
Partition Coefficient (Log Kow): Approximately 2.1
Auto-Ignition Temperature: Not determined
Decomposition Temperature: Above 200–220°C
Viscosity: Not applicable (solid)
Chemical Stability: Stable under recommended conditions of storage and use.
Reactivity: No dangerous reactions known under normal use.
Conditions to Avoid: Avoid moisture, excessive heat, direct sunlight, and open flames.
Incompatible Materials: Avoid mixing with strong oxidizing agents, strong acids and bases.
Hazardous Decomposition Products: May produce iodine vapors, oxides of carbon, nitrogen compounds, and other toxic fumes if burned or heated excessively.
Acute Toxicity: Oral LD50 (rat) reported as 779 mg/kg. Human response highly dose-dependent; overdose can cause serious endocrine and cardiac effects.
Routes of Exposure: Inhalation, ingestion, skin, and eye contact.
Potential Effects: Short-term exposure to large doses can cause sweating, rapid pulse, anxiety; chronic or high exposure could lead to thyrotoxicosis (hyperthyroidism symptoms).
Skin Irritation: Possible mild irritation with large or repeated exposures.
Eye Irritation: Possible mild irritation, do not allow contact.
Respiratory or Skin Sensitization: Not expected, but allergy is possible.
Carcinogenicity: Not expected to be carcinogenic based on animal data.
Reproductive Toxicity: Hormonal effects possible with misuse or high exposures.
Target Organs: Thyroid, heart, nervous system.
Other Information: Monitoring and clinical guidance recommended for all therapeutic or research use.
Ecotoxicity: Data limited for direct environmental impact; not expected to cause acute harm to aquatic life at low concentrations, but chronic effects not fully studied.
Persistence and Degradability: Likely biodegradable over time, but data lacking on exact rates in soil or water.
Bioaccumulation Potential: Low potential for bioaccumulation based on chemical structure.
Mobility in Soil: Expected to have moderate mobility due to partial solubility.
Other Adverse Effects: Do not discard directly into environmental systems—take steps to minimize environmental entry.
Waste Disposal Methods: Dispose as chemical waste in accordance with local, regional, or national legislation.
Do Not: Flush into water sources, sewers, or open environment.
Container Disposal: Empty containers should be rinsed and disposed of through licensed chemical disposal services.
Special Precautions: Incinerate in a controlled facility if allowed, or follow guidance for pharmaceuticals in lab or hospital settings.
UN Number: Not regulated as dangerous goods for transport by road (ADR), sea (IMDG), or air (IATA).
Proper Shipping Name: Not classified as hazardous for transport.
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions: Protect from excessive heat, direct sunlight, and do not expose to moisture during transit.
Environmental Hazards: Not a marine pollutant under IMDG code.
Transport in Bulk: Not applicable, not transported in bulk.
EU Regulations: Listed on EINECS/ELINCS inventory. Not classified under reach as a substance of very high concern.
US Regulations: Not specifically regulated as a hazardous material (OSHA, TSCA listed).
Canada: DSL compliant; classified for pharmaceutical and research use.
Other Applicable Laws: All health and safety, occupational, and pharmaceutical regulations may apply, especially in clinical, academic, and industrial environments.
Label Information: Requires pharmaceutical warning labels and handling precautions.
Restrictions: Use restricted to prescription or authorized personnel in medical and laboratory contexts.
