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Product Name: Thiamphenicol
Synonyms: Thiophenicol, Dextrosulphenidol
Chemical Formula: C12H15Cl2NO5S
CAS Number: 15318-45-3
Manufacturer or Supplier: [Specify company information if known]
Recommended Use: Veterinary antibiotic, pharmaceutical intermediate
Emergency Phone Number: [Insert emergency contact specific to company or region]
Hazard Class: Harmful if swallowed, inhaled or in contact with skin
GHS Label Elements: Warning, exclamation mark
Routes of Entry: Skin, inhalation, ingestion, eyes
Pictograms: Health hazard symbol, exclamation mark
Potential Health Effects: Causes irritation to eyes, skin, and respiratory tract; possible allergic reactions; hematological effects with repeated exposure
Environmental Risks: Dangerous to aquatic life with long-term effects
Chemical Name: Thiamphenicol
Concentration: ≥99%
Impurities: Related substances less than 1%
Molecular Weight: 357.2 g/mol
Hazardous Components: No significant hazardous impurities expected at levels required to be listed under current regulations
Inhalation: Move person to fresh air, monitor breathing, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash skin with plenty of water and soap, seek medical advice upon irritation
Eye Contact: Rinse immediately with plenty of water for several minutes, remove contact lenses if present and easy, get medical help
Ingestion: Rinse mouth thoroughly, do not induce vomiting, give water if conscious and alert, consult a physician urgently
Most Important Symptoms: Irritation, headache, drowsiness, blood disorder symptoms with repeated exposure
Immediate Medical Attention: Recommended for any persistent or severe symptoms
Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide
Unsuitable Extinguishing Media: Avoid high-pressure water streams which may spread substance
Specific Hazards: Combustion can produce irritant and toxic fumes including hydrogen chloride, sulfur oxides, nitrogen oxides
Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Special Precautions: Move containers from fire area if safe to do so, cool unopened containers with water spray
Personal Precautions: Use personal protective equipment, avoid contact with skin, eyes, and clothing, ensure proper ventilation
Emergency Procedures: Evacuate non-essential personnel, prevent further leakage or spillage
Spill Cleanup Methods: Absorb spill with inert material (sand, earth), collect in suitable container for disposal, wash area with water
Environmental Protection: Prevent product from entering drains, watercourses, or soil
Handling: Avoid direct contact, use with adequate ventilation, wear recommended protective gear, prohibit eating and drinking in area
Safe Handling Advice: Follow good industrial hygiene practices
Storage Conditions: Store tightly closed in original container, in a cool, dry, well-ventilated area away from incompatible materials
Incompatible Materials: Strong oxidizing agents, bases, acids
Storage Temperature: Store at room temperature or as indicated by manufacturer
Exposure Limits: No established occupational exposure limits for thiamphenicol; avoid exposure
Engineering Controls: Use local exhaust ventilation or other engineering controls to keep airborne levels low
Personal Protective Equipment (PPE): Chemical-resistant gloves, safety goggles, lab coat or protective suit, NIOSH-approved respirator for dust when necessary
Hygiene Measures: Wash thoroughly after handling, do not eat or smoke during handling
Appearance: White to off-white crystalline powder
Odor: Odorless or faint chemical odor
pH: Not applicable (insoluble in water)
Melting Point: 153-155°C
Boiling Point: Not available (decomposition before boiling)
Solubility: Sparingly soluble in water; soluble in ethanol, methanol, acetone, and dimethylformamide
Vapor Pressure: Not significant at room temperature
Density: 1.56 g/cm3
Partition Coefficient (log Kow): Approximately 0.37
Flash Point: Not applicable (non-flammable solid)
Chemical Stability: Stable under standard storage conditions
Reactivity: No hazardous reactivity under normal processing
Incompatible Materials: Strong oxidizers, acids
Hazardous Decomposition Products: Hydrogen chloride, sulfur oxides, nitrogen oxides during burning
Polymerization: No hazardous polymerization expected
Acute Toxicity: LD50 (oral, rat): 2,300 mg/kg
Skin Irritation: May cause mild to moderate irritation
Eye Irritation: Causes irritation
Chronic Effects: Prolonged or repeated exposure may cause effects on blood and bone marrow; rare cases of aplastic anemia reported with similar compounds
Sensitization: Allergic skin reaction possible
Carcinogenicity: Not classified as carcinogen by IARC, OSHA, or NTP
Reproductive Toxicity: Data not sufficient for classification
Mutagenicity: Some evidence in lab studies for genotoxic effects, relevance to human exposure is uncertain
Ecotoxicity: Toxic to aquatic organisms; can have long-term adverse effects in water environments
Persistence and Degradability: Not readily biodegradable
Bioaccumulative Potential: Low to moderate potential due to log Kow
Mobility in Soil: Limited by low water solubility; potential for leaching in specific conditions
Other Adverse Effects: Risk for antibiotic resistance development in environmental bacteria
Disposal Methods: Dispose of contents/container in accordance with local, regional, national, and international regulations
Contaminated Packaging: Triple rinse containers, dispose as hazardous waste
Environmental Precautions: Do not allow to enter sewers, surface water, or soil
Special Instructions: Incineration preferred for significant quantities
UN Number: Not assigned
UN Proper Shipping Name: Not regulated by most international transport agencies
Transport Hazard Class: Not classified
Packing Group: Not designated
Environmental Hazards: Marine pollutant (as bulk chemical)
Transport Precautions: Protect packages from physical damage and moisture during transport
Inventory Status: Listed in TSCA, EINECS/ELINCS, and other global inventories
Relevant Regulations: Complies with applicable workplace, environmental, and consumer safety regulations
Labeling Requirements: Warning labels required for containers under OSHA Hazard Communication Standard
Other Regulatory Controls: Governed by veterinary and antibiotic regulations in many countries
Additional Notes: Not subject to specific international control regimes as a hazardous chemical, observe national and regional health, safety, and environmental laws
