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Material Safety Data Sheet for Thiamine Nitrate

Identification

Product Name: Thiamine Nitrate
Chemical Name: Thiamine Mononitrate
SYNONYMS: Vitamin B1 Nitrate, Thiamin Mononitrate
CAS Number: 532-43-4
Molecular Formula: C12H17N5O4S
Recommended Use: Nutritional supplementation, pharmaceutical manufacturing, laboratory reagent
Manufacturer Details: Refer to supplier or distributor information for address and emergency contact numbers

Hazard Identification

Classification: Not classified as hazardous under GHS criteria
Main Health Hazards: May irritate eyes, skin, and respiratory tract if handled carelessly; exposure to large amounts can rarely cause allergic reactions
Signal Word: None required
Hazard Statements: Dust may form explosive mixtures with air in rare conditions
Precautionary Statements: Avoid unnecessary exposure, prevent dust formation, wear appropriate protective gear, store securely out of children’s reach
Symbols: Not applicable
Routes of Exposure: Inhalation, ingestion, eye or skin contact

Composition / Information on Ingredients

Chemical Identity: Thiamine Nitrate
CAS Number: 532-43-4
Proportion: >98%
Impurities: Trace vitamins and excipients below 2%, including possible residual solvents

First Aid Measures

Eye Contact: Rinse immediately with clean water for 15 minutes and seek medical attention for persistent irritation
Skin Contact: Remove contaminated clothing, wash with plenty of soap and water; seek advice if rash or discomfort develops
Inhalation: Move person to fresh air, keep warm and at rest, consult a doctor if symptoms (coughing, dizziness) persist
Ingestion: Rinse mouth and drink water if conscious, never give anything by mouth to an unconscious person, contact a healthcare professional
Special Notes for Doctors: Treat symptomatically, monitor for allergic responses

Fire-Fighting Measures

Suitable Extinguishing Media: Use dry chemical powder, carbon dioxide, water spray, or regular foam
Special Hazards: May emit noxious fumes like nitrogen oxides, carbon monoxide if combusted
Protective Equipment: Firefighters use positive pressure self-contained breathing apparatus and full protective clothing
Further Instructions: Cool containers exposed to flames with water spray to avoid bursting

Accidental Release Measures

Personal Precautions: Evacuate unnecessary personnel, wear gloves, safety goggles, dust mask, ensure adequate ventilation
Environmental Precautions: Prevent entry into drains, waterways, or soil
Spill Management: Sweep up carefully, avoid raising dust, place in labeled container for disposal, wash spill site with water

Handling and Storage

Handling: Handle in a well-ventilated area, minimize dust generation, avoid contact with skin, eyes, clothing, use personal protection
Storage: Store tightly closed in a cool, dry, well-ventilated place away from incompatible substances like strong acids or oxidizing agents, protect from direct sunlight
Other Precautions: Keep away from foodstuffs and beverages; use dedicated equipment for handling

Exposure Controls and Personal Protection

Occupational Exposure Limits: Not established for thiamine nitrate; apply dust exposure standards (< 10 mg/m3 total dust)
Engineering Controls: Use mechanical exhaust or general ventilation to reduce dust levels
Personal Protective Equipment: Lab coat, chemical-resistant gloves, safety glasses, approved dust respirator if required
Hygiene Practices: Wash thoroughly after handling, do not eat or drink while using the chemical, change contaminated clothing

Physical and Chemical Properties

Appearance: White or nearly white crystalline powder
Odor: Odorless
Melting Point: Decomposes above 250°C
Solubility: Freely soluble in water, insoluble in most organic solvents
pH (5% Solution): 6.5-7.5
Boiling Point: Not applicable (decomposes before boiling)
Vapor Pressure: Negligible
Density: Approximately 1.45 g/cm³

Stability and Reactivity

Chemical Stability: Stable at room temperature under recommended conditions
Conditions to Avoid: High temperatures, moisture, direct light, generation of dust
Incompatible Materials: Strong oxidizers, strong acids, alkalis; these may cause degradation
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon oxides on thermal decomposition
Hazardous Polymerization: Does not occur

Toxicological Information

POTENTIAL HEALTH EFFECTS: Low acute oral toxicity; large doses may cause mild gastrointestinal discomfort
LD50 (Oral, Rat): >5000 mg/kg
Sensitization: Rare allergic skin reactions in sensitized individuals
Chronic Toxicity: No evidence in humans when used as directed; high repeated exposures not advised
Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA
Mutagenicity: No data indicating mutagenic effects

Ecological Information

Aquatic Toxicity: Not expected to harm aquatic organisms at typical environmental concentrations
Mobility: Readily soluble in water, may leach to groundwater if large spills occur
Persistence/Degradability: Biodegradable
Bioaccumulative Potential: Low, based on water solubility and low partition coefficient
Other Adverse Effects: Not expected to interfere with wastewater treatment

Disposal Considerations

Waste Treatment Methods: Dispose of leftover material in accordance with local, regional, and national regulations; incineration preferred for organic materials
Container Disposal: Empty containers should be rinsed and recycled or disposed as required by jurisdiction
Precautions: Prevent discharge into environment where possible; avoid generating dust during disposal

Transport Information

UN Number: Not regulated for transport
Proper Shipping Name: Thiamine Nitrate
Transport Hazard Class: Not classified as hazardous for land, sea, or air
Packing Group: None assigned
Special Precautions: Transport in labeled, tightly closed containers; avoid excessive temperatures and direct sunlight

Regulatory Information

Regulatory Status: Not listed as hazardous according to OSHA Hazard Communication Standard
Inventory Listing: Registered on TSCA, EINECS, DSL, AICS
SARA Title III: Not listed per Sections 302, 304, 313
California Proposition 65: Not listed
Other Regulations: Follow local workplace safety regulations; observe national and international food additive, pharmaceutical, and chemical rules