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Material Safety Data Sheet: Thiamine Hydrochloride

Identification

Product Name: Thiamine Hydrochloride
Chemical Name: Thiamine mononitrate, hydrochloride
CAS Number: 67-03-8
Molecular Formula: C12H17ClN4OS
Molecular Weight: 337.81 g/mol
Company Identification: Manufacturers or distributors of laboratory reagents, including contact phone numbers for emergencies
Intended Use: Vitamin B1 supplementation, pharmaceutical formulation, laboratory reagent
Synonyms: Vitamin B1 HCl, Aneurin hydrochloride
Emergency Contact: Refer to company or local poison control hotline

Hazard Identification

Classification: Not classified as hazardous under GHS
Physical State: Solid, crystalline powder
Color: White to off-white
Odor: Faint, characteristic
Health Hazards: Dust may irritate respiratory tract, eyes, and skin; ingestion in large amounts may cause mild digestive upset
Environmental Hazards: Presents minimal risk; avoid large-scale release
Precautionary Statements: Prevent dust formation, utilize appropriate PPE, avoid inhaling, wash hands thoroughly after handling
Signal Word: Not required under GHS criteria
Pictograms: None mandated; standard lab safety iconography suggested

Composition / Information on Ingredients

Chemical Name: Thiamine Hydrochloride
CAS Number: 67-03-8
Concentration: Above 98% purity
Impurities: Trace water and/or related vitamin B1 derivatives (generally below 2%)
Other Components: Product offered as a single substance, no solvents or excipients present

First Aid Measures

Inhalation: Move exposed individual to fresh air, provide comfortable position, seek medical attention if coughing or difficulty in breathing develops
Skin Contact: Remove contaminated clothing and gently wash with soap and water for several minutes—note any persistent irritation and contact medical personnel
Eye Contact: Rinse slowly and gently with clean water for at least 15 minutes; avoid vigorous rubbing, remove contact lenses if present and easy to do, obtain further medical review if symptoms persist
Ingestion: Rinse mouth, offer water to drink, avoid inducing vomiting, monitor for symptoms and consult physician if discomfort or adverse effects arise

Fire-Fighting Measures

Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, or foam to cool fire-exposed containers
Hazardous Combustion Products: May generate nitrogen oxides, sulfur oxides, carbon monoxide/dioxide, hydrochloric acid fumes upon burning
Protective Equipment: Firefighters require self-contained breathing apparatus and full protective gear
Special Procedures: Move containers from fire area if it can be done without risk, avoid inhaling vapors, cool surfaces with water spray to prevent pressure build-up
Unusual Fire Hazards: Dust may form explosive mixtures with air; minimize dust dispersal

Accidental Release Measures

Personal Precautions: Avoid generating dust, ventilate area, use respiratory protection if dust exposure possible
Environmental Precautions: Keep product out of water supplies, sewers, and soil; large spills call authorities for support
Spill Cleanup Methods: Sweep up material using non-sparking tools, place in clean, dry, labeled container for proper disposal
Decontamination: Wash spill area with water and mild detergent, avoid excessive water use to prevent unnecessary runoff

Handling and Storage

Handling Advice: Handle with care; use appropriate personal protective equipment including gloves and safety glasses; avoid eating or drinking while using this product; good laboratory practice includes minimizing dust generation through attentive technique
Storage Conditions: Store in tightly closed container, away from direct sunlight, heat, and moisture; place containers in cool, dry, well-ventilated area with clear labeling
Incompatible Materials: Strong oxidizing agents, reducing agents, bases
Special Considerations: Avoid contamination; assign dedicated utensils and equipment if using in pharmaceutical contexts

Exposure Controls and Personal Protection

Engineering Controls: Use in vented area or fume hood, avoid open containers where dust may spread; fit local exhaust as needed
Respiratory Protection: Wear approved dust masks or respirators when handling large quantities or in poorly ventilated areas
Skin Protection: Wear chemical-resistant gloves (nitrile, latex), lab coat or apron
Eye Protection: Safety goggles or glasses meeting local standards
Other Protection: Wash hands thoroughly after use; avoid touching face, eyes, or mouth; remove contaminated clothing promptly

Physical and Chemical Properties

Appearance: Crystalline powder
Color: White to pale yellow
Odor: Slight, typical for B vitamin compounds
pH (5% solution): About 2.7–3.4
Melting Point/Range: Decomposes at approximately 250°C
Solubility in Water: Highly soluble
Relative Density: 1.74 g/cm3 (approximate)
Partition Coefficient (n-octanol/water): Not measured; expected to stay in aqueous phase
Vapor Pressure: Not relevant as solid
Boiling Point: Not applicable—decomposes
Flash Point: Not determined for solids
Evaporation Rate: Not applicable
Upper/Lower Flammability: No data specific; dust presents general combustible risk

Stability and Reactivity

Stability: Stable under standard room temperature and dry, closed conditions
Polymerization: Will not occur
Conditions to Avoid: Prolonged exposure to air, moisture, excessive heat, direct sunlight
Materials to Avoid: Strong oxidizers, strong alkaline and reducing agents
Hazardous Decomposition Products: Degradation can release toxic fumes of nitrogen oxides, sulfur oxides, hydrochloric acid, carbon oxides
Reactivity: No hazardous reactivity expected with common substances in a controlled environment

Toxicological Information

Acute Toxicity (oral, rat): LD50 estimated > 5,000 mg/kg
Skin/Eye Irritation: May cause mild irritation with direct contact
Respiratory Sensitization: Low likelihood except in pre-existing allergy
Chronic Toxicity: No evidence of long-term harm at routine exposure levels; toxic effects expected only at much higher doses
Mutagenicity/Carcinogenicity: Not classified as mutagenic or carcinogenic by IARC, OSHA, or NTP
Reproductive Toxicity: No documented teratogenic effects at nutritional supplementation levels

Ecological Information

Ecotoxicity: Low bioaccumulation potential; not anticipated to pose risk at concentrations present in effluent
Persistence and Degradability: Biodegradable under standard environmental conditions
Mobility in Soil: Soluble in water; moderate mobility if released
Bioaccumulation Potential: Not anticipated due to vitamin structure and water solubility
Aquatic Toxicity: No significant hazard at realistic discharge rates
Other Adverse Effects: Data suggests negligible environmental risk when disposed according to regulations

Disposal Considerations

Waste Disposal: Collect waste in labeled containers, follow local and national regulations for disposal of laboratory chemical waste
Disposal Methods: Incinerate or landfill through licensed contractor; do not flush to sewer
Contaminated Packaging: Containers should be rinsed, rendered unserviceable, and managed as chemical waste
Environmental Precautions: Take steps to avoid accidental release, especially in large quantities, due to potential cumulative effects
Hazardous Waste Number: Not classified as hazardous waste under U.S. RCRA regulations

Transport Information

UN Number: Not assigned—material not regulated as hazardous for transport
Proper Shipping Name: Thiamine Hydrochloride
Transport Hazard Class: Not classified
Packing Group: Not assigned
Labeling Requirements: Standard chemical labeling practices recommended
Special Transport Precautions: Keep container sealed, protected from moisture and direct sunlight, avoid packaging that generates dust

Regulatory Information

TSCA (United States): Listed
DSL (Canada): Listed
EU (REACH): Registered or exempted from registration due to low hazard profile
OSHA Status: Not considered hazardous
SARA Title III: Not subject to reporting
WHMIS (Canada): Not controlled
Other Regulatory Notes: Meets requirements for vitamins in food and pharmaceutical settings with prescribed purity; no special restrictions for consumer or industrial use under prevailing regulations; users should keep updated with local legislation on chemical handling and disposal