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Product Name: Tetramisole Hydrochloride
Chemical Formula: C11H12N2S·HCl
Synonyms: Levamisole hydrochloride, Tetramisole HCl
CAS Number: 5086-74-8
Intended Use: Veterinary anthelmintic, research chemical
Supplier: Refer to local manufacturer contact information
Emergency Contact: Local emergency services or poison control
GHS Classification: Acute toxicity oral (Category 3), Acute toxicity dermal (Category 4), Eye irritation (Category 2A), Skin irritation (Category 2)
Signal Word: Danger
Hazard Statements: Toxic if swallowed; causes skin and eye irritation; harmful in contact with skin
Pictograms: Skull and crossbones, exclamation mark
Precautionary Statements: Avoid breathing dust and use only outdoors or in well-ventilated area. Do not get in eyes, on skin, or on clothing. Wash hands thoroughly after handling. Wear protective gloves and eye protection to minimize risks.
Chemical Name: Tetramisole Hydrochloride
Concentration: 98-100%
Impurities: May contain trace decomposition products
Molecular Weight: 240.75 g/mol
Hazardous Components: No stabilizers or solvents mixed in this pure grade
Inhalation: Move to fresh air right away. If breathing appears difficult, supply oxygen or assist ventilation as needed. Seek medical attention quickly.
Skin Contact: Remove contaminated clothing. Rinse skin immediately with plenty of water for at least fifteen minutes. Get medical attention if irritation persists.
Eye Contact: Rinse cautiously with plenty of water for at least fifteen minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek physician advice if discomfort remains.
Ingestion: Rinse mouth with water only if person is conscious. Never give anything by mouth to an unconscious person. Get emergency medical help without delay.
Important Symptoms/Effects: Gastrointestinal symptoms, headache, dizziness, possible central nervous system depression or convulsions at high dose.
Advice for Medical Personnel: Symptomatic and supportive treatment. Monitor respiratory and cardiac function.
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide or foam. Avoid direct water jet which may spread material.
Hazardous Combustion Products: Hydrogen chloride, nitrogen oxides, sulfur oxides, carbon oxides.
Protection for Firefighters: Use self-contained breathing apparatus and full protective equipment. Approach fire from upwind side to avoid smoke exposure.
Fire Hazards: Dust can form explosive mixtures with air. Toxic fumes can develop under fire conditions.
Personal Precautions: Wear suitable protective clothing, gloves, and safety goggles. Avoid dust formation and breathing dust. Remove all sources of ignition.
Environmental Precautions: Keep out of drains and waterways. Prevent further leaking or spillage if safe to do so.
Cleanup Methods: Sweep up carefully without creating dust. Collect in a sealed, labeled container for disposal. Ventilate area and wash site after material pick-up is complete.
Emergency Procedures: Evacuate personnel to safe area if necessary.
Precautions for Safe Handling: Use in well-ventilated place. Avoid contact with skin, eyes, and clothing. Wear personal protective equipment when handling. Minimize dust generation and accumulation.
Conditions for Safe Storage: Keep container tightly closed in a dry, cool, well-ventilated location away from incompatible substances such as strong oxidizers. Store locked up and keep out of reach of children or untrained persons.
Other Advice: Avoid eating, drinking, or smoking in work areas. Wash hands after use.
Occupational Exposure Limits: No specific OSHA or ACGIH exposure limits assigned.
Engineering Controls: Local exhaust ventilation or fume hood recommended. Facilities for washing should be readily available.
Personal Protective Equipment:
Respiratory Protection: NIOSH-approved dust mask or respirator as needed.
Eye Protection: Chemical splash goggles or safety glasses.
Hand Protection: Impervious gloves such as nitrile or latex.
Skin/Bodily Protection: Lab coat or protective clothing to minimize exposure.
Appearance: White or off-white crystalline powder
Odor: Odorless
pH (1% Solution): About 4.0 to 5.5
Melting Point: Around 245-250°C (decomposes)
Boiling Point: Not available (decomposes)
Solubility: Freely soluble in water, slightly soluble in ethanol
Vapor Pressure: Not applicable
Specific Gravity: No reliable data
Flash Point: Not flammable as solid
Partition Coefficient: log Pow <1
Explosive Properties: Dust may be explosive in air under certain conditions
Chemical Stability: Stable under recommended storage conditions.
Reactivity: No dangerous reactions known under normal conditions.
Conditions to Avoid: Excessive heat, moisture, open flames, and incompatible materials.
Incompatible Materials: Strong oxidizers, strong acids.
Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, sulfur oxides, carbon monoxide.
Routes of Exposure: Inhalation, ingestion, skin, and eye contact.
Acute Toxicity: Oral LD50 (rat): 25-100 mg/kg. Skin LD50 data unavailable. Causes serious gastrointestinal upset in humans.
Symptoms: Nausea, vomiting, headache, muscle tremors, dizziness, fatigue, ataxia.
Chronic Exposure: Risk of blood cell count changes, agranulocytosis, possible central and peripheral neurotoxicity.
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a confirmed carcinogen.
Mutagenic Effects: Studies have indicated some evidence of mutagenicity in animal tests.
Reproductive Effects: No significant data, use caution.
Environmental Fate: Not expected to persist in the environment for extended periods, but breakdown in soil and water can produce toxic metabolites.
Ecotoxicity: Harmful to aquatic organisms and may cause long-term adverse effects in the aquatic environment.
Bioaccumulation Potential: Low significant bioaccumulation due to rapid degradation.
Mobility in Soil: Likely to have some mobility based on water solubility.
Other Information: Avoid release to the environment. Collect spillage for disposal.
Waste Treatment Methods: Dispose of in accordance with local, state, and national regulations. Do not dump into drains, waterways, or soil.
Contaminated Packaging: Triple-rinse and dispose of as hazardous waste in compliance with all regulations.
Incineration: Only approved chemical incinerators with emissions controls should be used for this substance.
Other Details: Encourage recycling or re-use whenever possible, minimize generation of waste.
UN Number: Consult local authority
Proper Shipping Name: TETRAMISOLE HYDROCHLORIDE
Hazard Class: Refer to appropriate transport regulation (ADR, IMDG, IATA). Often regulated as hazardous when shipped in bulk.
Packing Group: III
Transport Label: Toxic substance
Special Precautions: Secure packaging to prevent leakage or dust generation during transit. Provide emergency response data and appropriate shipping documents.
Labeling: In line with GHS and local chemical safety regulations, clear hazard statements and pictograms must be provided.
OSHA Status: Hazardous chemical as defined by OSHA Hazard Communication Standard.
TSCA: Listed on the Toxic Substances Control Act inventory.
REACH Status (EU): Not currently subject to registration; recommendation for chemical management and monitoring.
Other Country-Specific Regulations: May be restricted or prohibited for certain uses—consult applicable regional or national regulations.
Restrictions: Not authorized for human use in many regions due to toxicity and adverse health effects.
