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Product Name: Sulfadimidine
Chemical Name: 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl) benzenesulfonamide
Synonyms: Sulfamethazine
CAS Number: 57-68-1
Recommended Use: Pharmaceutical intermediate, veterinary antibiotic
Manufacturer Information: Commercial suppliers and chemical manufacturers
Emergency Contact: Local poison control, healthcare providers, fire department
GHS Classification: Eye irritation, skin sensitization, acute toxicity (oral)
Signal Word: Warning
Hazard Statements: May cause skin and eye irritation, respiratory irritation, allergic reactions with repeated or excessive contact, harmful if swallowed
Pictograms: Exclamation mark (irritant), health hazard
Precautionary Statements: Avoid contact with eyes, skin, or clothing; Use adequate ventilation; Wash hands thoroughly after handling; Do not eat, drink, or smoke near material
Chemical Identity: Sulfadimidine
CAS Number: 57-68-1
Concentration: Up to 100%, depending on preparation
Impurities: May contain trace solvents, related sulfonamides, moisture (from storage)
Other Ingredients: No known non-hazardous ingredients reported
Inhalation: Move individual to fresh air, seek medical attention if breathing becomes difficult
Skin Contact: Remove contaminated clothing, wash area thoroughly using soap and water
Eye Contact: Immediately flush with gentle running water for a minimum of 15 minutes, remove contact lenses, get medical advice
Ingestion: Rinse mouth, do not induce vomiting unless directed by medical staff, seek immediate medical help
Symptoms: Irritation, redness, itching, coughing, nausea, allergic sensitivity
Medical Attention: Monitor airway, breathing, circulation in all routes; treat symptomatically
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray
Unsuitable Media: Direct high pressure water may spread powder
Hazardous Combustion Products: Emits toxic fumes under fire (sulfur oxides, nitrogen oxides, carbon oxides)
Protection for Firefighters: Self-contained breathing apparatus, full protective gear
Fire Hazards: Substance may burn but fails to ignite readily; dust may form explosive mixture with air
Advice: Move away containers from fire area if safe, avoid inhaling fumes
Personal Precautions: Wear chemical-resistant gloves, goggles, lab coat, and dust mask
Environmental Precautions: Prevent further leakage, spillage into drains, surface waters, soil
Cleanup Methods: Sweep up carefully without creating dust, place in suitable waste containers; ventilate area
Decontamination: Wash area with large volume of water ensuring no release into the environment
Disposal: Dispose of through licensed waste disposal company following regulations
Safe Handling: Use in well-ventilated area wearing appropriate personal protective equipment; avoid formation of dust; avoid contact with skin, eyes, and clothing
Hygiene Measures: Wash hands thoroughly after handling; remove contaminated clothing before reuse
Storage: Store tightly closed in a cool, dry, well-ventilated area; protect from moisture and light; keep separate from incompatible chemicals (e.g., strong oxidizers)
Packaging Materials: Use original container or chemical-resistant secondary containment
Storage Limitations: Keep separate from food, beverages, animal feed
Occupational Exposure Limits: No specific limit in many regions, general dust limits apply (OSHA PEL for nuisance dust: 15 mg/m³ total, 5 mg/m³ respirable fraction)
Engineering Controls: Local exhaust ventilation, use of fume hood or glove box for large quantities
Personal Protective Equipment: Chemical safety goggles, dust mask or N95 respirator, impervious gloves, lab coat or coveralls
Monitoring Procedures: Regular assessment of workplace air, medical surveillance for sensitization
Environmental Controls: Do not allow product to enter public sewer systems, surface waters or soil directly
Appearance: White to slightly yellow crystalline powder
Odor: Slight odor or odorless
Molecular Weight: 278.33 g/mol
Solubility in Water: Slight, increases with alkalinity
Melting Point: 190-193°C
pH: Slightly acidic to neutral (5.6–6.4 in aqueous solution)
Boiling Point: Decomposes
Density: 1.35–1.38 g/cm³
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log Pow): Approximately 0.1
Flammability: Not easily ignitable, but combustible under strong heat
Evaporation Rate: Not applicable (solid)
Chemical Stability: Stable under recommended handling and storage conditions
Reactivity: Non-reactive under normal conditions
Conditions to Avoid: Excess heat, exposure to sunlight, moisture, strong oxidizing conditions
Incompatible Materials: Strong oxidizers, acids, alkalis, strong reducing agents
Hazardous Decomposition: Produces toxic fumes like sulfur oxides, nitrogen oxides, carbon dioxide on combustion or decomposition
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity Data: Oral LD50 (rat) ~6600 mg/kg; higher doses may cause gastrointestinal irritation, ataxia, convulsions
Chronic Effects: Prolonged or repeated exposure may cause dermal sensitization, allergic reactions, blood and liver effects
Irritation: Possible eye and skin irritation
Sensitization: Documented in susceptible individuals
Other Health Effects: Allergic skin reactions, possible impact on red blood cell count upon misuse or excessive exposure, risk increases with impaired kidney function or folic acid deficiency
Carcinogenicity: Not listed as carcinogen by IARC, NTP, OSHA
Ecotoxicity: Moderately toxic to aquatic life, particularly algae and invertebrates
Persistence and Degradability: Slowly biodegradable in some environments
Bioaccumulation Potential: Low, log Pow suggests reduced bioaccumulation
Mobility in Soil: Medium; can enter groundwater if released in volume
Other Adverse Effects: May disrupt nitrifying bacteria in wastewater treatment
Precautions: Prevent release to sewers or flora/fauna habitat
Waste Disposal Methods: Collect unusable product and contaminated material for shipment to licensed chemical waste disposal facility
Container Disposal: Empty containers thoroughly before recycling or disposal; follow all federal, state, and local regulations
Precautionary Disposal: Do not flush into water systems, avoid contamination of soil and surface water
UN Number: Not regulated as hazardous for transport in most regions
Transport Hazard Class: Non-hazardous as per ADR/RID/IMDG/IATA/ICAO
Packing Group: Not assigned
Shipping Name: Sulfadimidine
Special Precautions: Avoid shipment near foodstuffs or oxidizing substances; package securely to avoid breakage or leakage; maintain cool, dry conditions
Environmental Hazards: Not designated marine pollutant
Emergency Transport Guidance: Basic first aid; prevent spillage and dust formation in transit
Safety, Health, Environmental Regulations: Subject to workplace safety standards and right-to-know laws
OSHA Status: Not specifically regulated
TSCA Status: Listed on U.S. TSCA inventory
REACH/CLP Status (EU): Registered or pre-registered substance; subject to general chemical safety reporting
Other International Regulations: May be classified under pharmaceutical, toxics, or antibiotic controls; follow specific national and regional requirements
Label Requirements: Comply with Hazard Communication Standard (GHS labeling)
Restrictions: Not for use in food production, direct food applications, or as a consumer substance without prescription
Other Notes: Variable controls in different countries for storage, handling, use, and disposal, especially with respect to bulk shipments for veterinary or industrial use
