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Product Name: Streptomycin Sulfate
Chemical Formula: C21H39N7O12·H2SO4
Other Names: Streptomycin, Streptomycin hemisulfate
Recommended Uses: Pharmaceutical antibiotic, laboratory reagent
Manufacturer Details: Contact information listed on original packaging or supplier website
Emergency Telephone Number: Refer to local and national poison control or emergency services
Relevant Identified Uses: Used for bacterial infection research, cell culture applications, not for human therapeutic use unless prescribed
UN Number: Not assigned for non-bulk, research usage
Classification: Eye irritation (Category 2A), Skin sensitization (Category 1), Respiratory sensitization (Category 1), Reproductive toxicity (Category 2)
GHS Label Elements: Exclamation mark, Health hazard pictogram
Hazard Statements: May cause eye and skin irritation. May cause allergic skin and respiratory reactions. Possible risk of harm to the unborn child during pregnancy.
Precautionary Statements: Avoid breathing dust. Wash hands thoroughly after handling. Use only in well-ventilated areas. Wear suitable personal protective equipment.
Potential Health Effects: Short-term exposure can trigger allergy symptoms, eye irritation, or redness. Long-term exposure or high concentrations may impact kidney and hearing function.
Other Hazards: Not classified as highly flammable or explosive
Chemical Name: Streptomycin Sulfate
CAS Number: 3810-74-0
Concentration: Pure substance or as indicated on label (typically >95%)
Impurities or Stabilizing Additives: Trace amounts of water and inorganic salts may be present, not identified as hazardous at typical impurity levels
Molecular Weight: 728.69 g/mol
Relevant Identifiers: None reported for standard research grade
Inhalation: Move affected person to fresh air. Seek immediate medical attention if difficulty breathing or respiratory symptoms appear.
Ingestion: Rinse mouth immediately; do not induce vomiting unless directed by medical personnel. Seek medical advice.
Skin Contact: Remove contaminated clothing. Rinse affected area with plenty of water for several minutes. Seek medical attention in case of irritation or rash.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Medical attention if irritation persists.
Most Important Symptoms: Allergic reactions, skin irritation, eye redness, difficulty breathing in sensitized individuals
Special Advice for Physicians: Treat symptomatically; monitor for delayed symptoms such as allergic response or respiratory distress
Suitable Extinguishing Media: Use water mist, dry powder, carbon dioxide, or foam, based on surrounding materials
Specific Hazards: Thermal decomposition may release irritating or toxic fumes including nitrogen oxides, sulfur oxides, and carbon oxides
Firefighter Protective Equipment: Wear self-contained breathing apparatus and full protective clothing
Special Information: Avoid inhalation of combustion products. Streptomycin sulfate does not ignite easily, but containers can rupture in intense heat.
Explosion Risk: Not known to form explosive dust-air mixtures under normal laboratory conditions
Personal Precautions: Avoid direct contact with skin or eyes. Ventilate area as much as possible. Wear suitable protective gloves, lab coat, and safety eyewear.
Environmental Precautions: Prevent entry into soil, sewers, or waterways. Notify authorities if large spill causes environmental risk.
Containment and Cleanup Methods: Sweep up spilled material carefully to avoid creating dust. Place in appropriate waste container for disposal. Clean affected area with water and detergent. Dispose according to local regulations. Wash hands thoroughly after cleanup.
Reporting Requirements: Not a listed hazardous substance under CERCLA or SARA but check local guidance for reporting significant accidental releases
Safe Handling: Handle with care to avoid generating dust or powder inhalation. Use within a chemical fume hood if available. Do not eat, drink, or smoke in the work area.
Storage Conditions: Keep tightly sealed in original container. Store away from strong oxidizers or acids. Stable at room temperature under dry, well-ventilated conditions.
Incompatibilities: Strong oxidizing agents or strong acids
Storage Area Design: Lockable chemical storage cabinet recommended for research labs. Keep container upright and properly labeled.
Special Requirements: Protect from excessive heat and moisture. Avoid exposure to light for long periods as some degradation may occur
Occupational Exposure Limits: No established OSHA or ACGIH exposure limits for this compound.
Engineering Controls: Use local exhaust ventilation, especially while weighing or dissolving powder. Laboratory fume hood recommended.
Personal Protective Equipment:
Eye Protection: Safety goggles or chemical splash goggles
Skin Protection: Disposable nitrile gloves, laboratory coat
Respiratory Protection: Use NIOSH-approved particulate respirator if handling large quantities or inadequate ventilation
Hygiene Measures: Wash hands and exposed areas before eating, drinking, or leaving the laboratory. Regular laundering of contaminated clothing
Environmental Controls: Procedures to contain release and prevent entry into drains or water systems
Appearance: White or off-white, crystalline solid powder
Odor: Odorless
Odor Threshold: Not determined
pH: Around 4.5–6.0 (1% in water)
Melting Point: Decomposes before melting
Boiling Point: Not applicable
Flash Point: Not flammable
Evaporation Rate: Not applicable
Solubility: Freely soluble in water; insoluble in organic solvents such as ethanol or chloroform
Vapor Pressure: Negligible at room temperature
Vapor Density: Not applicable
Relative Density: Approximately 1.4 g/cm³
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: Not self-igniting
Decomposition Temperature: Above 200°C
Viscosity: Not applicable to solids
Molecular Structure: Aminoglycoside antibiotic with multiple hydroxyl and amine groups
Chemical Stability: Stable in unopened containers stored at recommended conditions
Reactivity: Not highly reactive under normal laboratory conditions
Conditions to Avoid: Moisture, strong acids, extremes of pH, elevated temperature extended over long periods
Incompatible Materials: Strong oxidizing agents, strong acids
Hazardous Decomposition Products: Sulfur oxides, nitrogen oxides, carbon oxides, traces of ammonia upon heating or combustion
Polymerization: Not expected to occur
Acute Toxicity: LD50 (oral, rat) >5,000 mg/kg, showing low acute oral toxicity but should be handled with care due to potential allergic reactions
Routes of Exposure: Skin contact, inhalation, ingestion, eye contact
Symptoms: May cause skin irritation, allergic dermatitis, eye redness, respiratory distress in sensitized individuals
Sensitization: Skin and respiratory sensitizer, rare cases of occupational allergy reported
Chronic Health Effects: Prolonged or repeated exposure may affect kidney function or hearing (ototoxicity and nephrotoxicity) according to animal studies
Mutagenicity/Carcinogenicity: Not recognized as carcinogenic, negative in standard Ames mutagenicity tests, but healthcare workers should minimize long-term exposure
Reproductive Toxicity: Evidence of developmental toxicity in animal testing at high doses
Other Health Notes: Not volatile, so inhalation risk increases mainly through dust or aerosol formation during preparation or cleanup
Toxicity: May be toxic to aquatic organisms due to antibiotic action; disrupts beneficial bacteria populations in the environment
Persistence and Degradability: Degrades slowly in soil and water, may contribute to antibiotic resistance buildup in environmental bacteria
Bioaccumulation Potential: Not expected to bioaccumulate significantly in aquatic organisms
Mobility in Soil: High solubility in water, can migrate in moist or wet environments
Other Adverse Effects: Presence in waste streams can alter microbial ecology
Precautions: Avoid uncontrolled release to soil, surface water, or sewer systems
Waste Treatment Methods: Send as hazardous laboratory waste according to local, regional, or national regulations
Disposal of Product: Incinerate or landfill at approved facility; do not discharge undiluted material into municipal sewage systems
Disposal of Contaminated Packaging: Triple rinse, puncture, and dispose of in accordance with chemical waste requirements
Additional Recommendations: Efforts should be made to minimize waste generation and recovery/recycling where possible under pharma or research control
UN Number: Not regulated as dangerous goods for transport under typical research use quantities
Proper Shipping Name: Streptomycin Sulfate
Transport Hazard Class: Not classed as hazardous for transport by DOT, IATA, or IMDG
Packing Group: Not assigned
Environmental Hazards: Not classified as a marine pollutant for transport
Special Precautions for Transport: Use secondary containment to prevent leaking; keep away from incompatible materials
Transport in Bulk: Not applicable
OSHA Hazards: Skin and respiratory sensitizer; not listed as a carcinogen
SARA/Title III: Not a listed Extremely Hazardous Substance; not subject to SARA Section 313 reporting
TSCA Status: Exempt for research and development; may be listed for commercial applications
WHMIS Classification: D2B (Toxic Material Causing Other Toxic Effects)
California Proposition 65: Not listed
REACH Status (EU): Not pre-registered as a substance manufactured or imported over one ton per year
Other Regulatory Listings: Covered by standard research chemical limitations; refer to local environmental protection regulations for disposal and handling guidance
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
