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Product Name: Steroidal Saponins
Chemical Family: Saponins derived from steroid aglycones and glycosides
Synonyms: Spirostanol Saponins, Furostanol Saponins
Recommended Use: Research, pharmaceuticals, dietary supplements, agriculture
Supplier Information: Name, address, emergency phone number, and email
CAS Number: Varies depending on botanical source and specific structure
Product Codes: Assigned by manufacturer or distributor
Emergency Contact: 24-hour response line for spills or accidental exposure
Manufacturing Site: Address and presence of safety manager
GHS Classification: Acute Oral Toxicity Category 4, Skin Irritant Category 2, Eye Irritant Category 2A
Hazard Statements: Harmful if swallowed; causes skin and serious eye irritation
Pictograms: Exclamation mark indicating acute toxicity and irritation
Label Precautionary Statements: Avoid breathing dust, wash skin after handling, wear eye and face protection
Signal Word: Warning
Routes of Exposure: Inhalation, ingestion, skin, and eyes
Potential Health Effects: Nausea, vomiting, irritation to upper respiratory tract, dermatitis
Aggravated Medical Conditions: As with most saponin-rich materials, pre-existing respiratory or skin conditions may see increased reaction severity
Environmental Impact: Toxic to aquatic life if released in quantity
Main Components: Steroidal saponins (70–90%)
Impurities: Minor unsaponifiable lipids, plant proteins, sugars
Stabilizers/Preservatives: None intentionally added
Residual Solvents: Ethanol, methanol, or water (trace, post-extraction)
Source Plants: Dioscorea spp. (wild yam), Trigonella foenum-graecum (fenugreek), Asparagus spp.
Exact Composition: Mixture contains spirostanol and furostanol glycosides; the glycone portion consists of glucose, rhamnose; aglycone varies by source
Inorganic Content: Trace minerals from plant extraction process
Inhalation: Move victim to fresh air, provide oxygen if symptoms of respiratory distress develop, seek medical advice
Skin Contact: Remove contaminated clothing, rinse affected area with water for at least 15 minutes, apply soothing lotion if irritation persists
Eye Contact: Rinse eyes cautiously with water for 15–20 minutes, keep eyelids open, remove contact lenses if present
Ingestion: Rinse mouth with water, do not induce vomiting, drink small amounts of water, seek professional healthcare advice
Delayed Symptoms: Gastrointestinal discomfort, mild headache, or dizziness may develop
Notes to Physician: Symptomatic and supportive care, monitor for allergic reaction or irritation, no specific antidote
Suitable Extinguishing Media: Water spray, dry chemical, foam, CO2
Unsuitable Extinguishing Media: Not recommended to use strong water jets
Specific Hazards: Combustion may produce carbon monoxide, carbon dioxide, and other irritating gases
Protective Equipment: Self-contained breathing apparatus, full protective gear
Explosion Data: Product is a finely milled powder and can form explosive dust-air mixtures
Advice for Firefighters: Cool containers with water spray to prevent pressure buildup
Fire Residues: Collect and dispose of according to local regulations
Personal Protection: Wear dust mask, gloves, and goggles
Evacuation Procedures: Remove unnecessary personnel, avoid raising dust
Cleanup Procedures: Sweep up with tools designed to reduce airborne dust, shovel into waste container
Waste Disposal: Dispose in accordance with national and regional regulations
Environmental Precautions: Prevent released material from entering water systems
Decontamination: Wash area with water and detergent, ventilate space
Spill Control: Use methods that avoid creating mists or dust clouds
Handling Advice: Handle in a well-ventilated area, keep container tightly closed, use antistatic measures in powder transfer
Avoid: Inhalation of dust, contact with skin and eyes, incompatible chemicals such as strong oxidizers
Hygiene Measures: Wash hands thoroughly after use, do not eat or drink in work area, change contaminated clothing
Storage Recommendations: Store in cool, dry place, away from direct sunlight, segregate from food products, label containers clearly
Conditions to Avoid: High humidity, open flames, sources of strong static electricity
Container Requirements: Use plastic or coated metal drums with sealing lids; avoid glass in high-volume storage
Occupational Exposure Limits: No specific OEL assigned; handle using guidelines for nuisance dusts (10 mg/m³ total dust, 5 mg/m³ respirable dust as per OSHA/NIOSH)
Engineering Controls: Local exhaust ventilation, dust extraction, process enclosure
Personal Protection: Tight-fitting safety goggles, chemical-resistant gloves, dust mask or respirator (N95), protective apron or lab coat
Monitoring Procedures: Routine air sampling for dust concentration in production areas
Other Protection: Emergency eyewash station, safety shower in work area
Exposure Scenarios: Bulk handling, milling, packaging, and cleaning all require protective measures
Appearance: Fine, off-white to light brown powder
Odor: Faint, herbal
Odor Threshold: Not established
pH: 5.5–8.0 as aqueous suspension (1% w/v)
Melting Point/Freezing Point: Decomposes above 220°C, does not have defined melting point due to organic complex
Solubility: Sparingly soluble in water, increases with presence of mild surfactants; soluble in alcohol
Partition Coefficient (Log Kow): Not available for mixture
Boiling Point/Range: Not applicable
Flash Point: Not determined due to solid nature
Evaporation Rate: Not applicable
Flammability: May combust at high temperature in presence of ignition
Vapor Pressure: Negligible at standard conditions
Vapor Density: Not applicable
Density: 1.1–1.3 g/cm³
Auto-Ignition Temperature: >350°C
Decomposition Temperature: Above 220°C
Viscosity: Not applicable
Chemical Stability: Stable in sealed container under normal temperature and pressure
Conditions to Avoid: Exposure to excessive heat, moisture, open flame, static discharge
Incompatible Materials: Strong oxidants, acids, bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, irritating organic fumes
Polymerization: Will not occur
Reactivity: Product does not undergo violent reactions but can degrade in the presence of concentrated acids or bases
Routes of Exposure: Inhalation, ingestion, skin, eyes
Acute Toxicity: LD50 (oral, mouse): 200–1000 mg/kg depending on purity and botanical source
Chronic Toxicity: Animal studies link high doses to mild gastrointestinal irritation; limited evidence for other systemic toxicity
Skin Irritation: Causes mild to moderate irritation in sensitive individuals
Eye Irritation: Can provoke redness, discomfort for several hours
Respiratory Effects: Dust may provoke coughing, sneezing, shortness of breath in confined spaces
Allergic Reactions: Rare, possible in individuals with plant allergies
Carcinogenicity, Mutagenicity, Reproductive Toxicity: No data indicating carcinogenicity or mutagenicity at typical workplace exposures
Medical Surveillance: Not routinely required for casual handling, but advisable for workers in extraction and purification positions
Toxicity to Aquatic Life: Harmful to aquatic organisms at high concentrations due to surfactant properties
Persistence and Degradability: Biodegradable, but breaks down more slowly in low-temperature aquatic environments
Bioaccumulation Potential: Low; saponins do not concentrate in food chains
Soil Mobility: Limited, tends to bind with organic material
Other Adverse Effects: Excess release into natural waterways can create foaming and disrupt the respiration of aquatic species
Disposal in Environment: Avoid unintentional discharges to water bodies
Waste Treatment Methods: Dispose as nonhazardous organic waste if not contaminated with solvents or toxic chemicals
Container Disposal: Triple rinse and puncture before landfill or recycling; follow local hazardous waste guidelines if residues remain
Incineration: Permitted in facilities approved for organic dusts
Special Considerations: Do not discharge into drains, watercourses, or soil
Regulatory Guidance: Refer to local, state, and national waste disposal regulations for classification and disposal requirements
UN Number: Not classified as dangerous goods for transport under most national and international regulations
Proper Shipping Name: Not regulated
Transport Hazards Class: None assigned
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant in dry powder form
Transport Precautions: Use sealed, labeled containers; secure to prevent leaks; no special requirements for land, sea, or air
Special Considerations: Freight should accompany accurate shipping documents with emergency contact and product identification details
GHS Compliance: Meets requirements for labeling, hazard communication, and safety documentation
TSCA Inventory Status: Plant-derived saponins may be exempt as naturally occurring substances in the United States
EU Regulations/REACH Status: Saponins not individually listed; considered a mixture of naturally occurring glycosides
OSHA Hazard Communication: Covered under hazard communication standard; safety training required
WHMIS Classification (Canada): Not specifically listed; general dust hazard applies
Documentation Requirements: Safety datasheets must be up to date and accessible to workers
Local Regulations: Requirements determined by country and jurisdiction relating to food, pharmaceutical, or agricultural use
