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Product Name: Sodium Sulfamethoxazole
Synonyms: Sodium salt of 4-amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
CAS Number: 723-46-6
Molecular Formula: C10H10N3NaO3S
Recommended Use: Pharmaceutical applications, mainly as an antibacterial agent
Supplier Name: Contact local supplier or manufacturer for emergency phone number and address details
Emergency Telephone Number: [Local emergency contact]
GHS Classification: Acute toxicity (Oral, Category 4), Skin sensitizer (Category 1), Eye irritant (Category 2A)
Hazard Statements: Harmful if swallowed; may cause an allergic skin reaction; causes serious eye irritation
Precautionary Statements: Avoid breathing dust; wash thoroughly after handling; use protective gloves and eye protection
Signal Word: Warning
Pictograms: Exclamation mark
Route of Entry: Inhalation, ingestion, skin and eye contact
Target Organs: Eyes, skin, respiratory system
Chemical Name: Sodium Sulfamethoxazole
Common Name: Sodium salt of Sulfamethoxazole
Concentration: 100% (pure substance)
Impurities/Additives: Typically not present in significant quantities; refer to supplier for details
General Advice: Move exposed person to fresh air, remove contaminated clothing, wash skin with water and soap.
Inhalation: Take person into fresh air; seek medical attention if symptoms appear.
Skin Contact: Wash immediately with plenty of water; seek medical advice if irritation or allergic reaction develops.
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present; continue rinsing and get medical attention if irritation persists.
Ingestion: Rinse mouth; do not induce vomiting; seek immediate medical help
Suitable Extinguishing Media: Use dry chemical powder, carbon dioxide, foam, or water spray.
Unsuitable Extinguishing Media: Avoid high-pressure water jets.
Special Hazards: Combustion may release sulfur oxides, nitrogen oxides, and toxic fumes.
Protective Equipment: Wear self-contained breathing apparatus and full protective gear.
Advice for Firefighters: Approach from upwind, use water spray to cool surroundings, avoid inhalation of fumes
Personal Precautions: Evacuate area, wear appropriate protective equipment including gloves, goggles, and suitable respirator.
Environmental Precautions: Prevent material from entering drains, sewers, or water courses.
Methods for Cleanup: Sweep up without creating dust, place in a suitable container for disposal, ventilate area and wash spill site after material pickup is complete.
Reference to Other Sections: See sections on exposure controls and disposal considerations
Handling: Use in well-ventilated areas, avoid dust formation and contact with eyes, skin, and clothing. Practice good hygiene; do not eat, drink, or smoke when handling this substance.
Storage: Store in tightly closed, labeled containers in a cool, dry, well-ventilated area away from incompatible substances such as strong oxidizing agents and acids.
Storage Class: Store away from foodstuffs, direct sunlight, and sources of ignition
Control Parameters: No occupational exposure limit established by OSHA, NIOSH, or ACGIH.
Engineering Controls: Use chemical fume hood or effective local exhaust ventilation to minimize exposure.
Personal Protection: Wear impervious gloves (nitrile recommended), safety goggles or face shield, lab coat, and, in case of dust formation, approved respirator.
Hygiene Measures: Wash hands and exposed areas thoroughly after handling, remove contaminated clothing and wash before reuse
Appearance: White to off-white crystalline powder
Odor: Odorless
Molecular Weight: 275.27 g/mol
Melting Point: 169 – 171°C
Boiling Point: Decomposes before boiling
Solubility: Freely soluble in water
pH (1% solution): 9.0 – 10.5
Relative Density: Approx. 1.6 g/cm³
Vapor Pressure: Not applicable
Partition Coefficient (log Kow): Data not available
Flash Point: Not combustible under normal conditions
Chemical Stability: Stable under recommended storage conditions.
Reactivity: Incompatible with strong oxidizing agents, acids, and bases.
Hazardous Reactions: Hazardous polymerization does not occur under normal handling.
Decomposition Products: May produce sulfur oxides, nitrogen oxides, carbon monoxide, and carbon dioxide on thermal decomposition.
Protect From: Excessive heat, moisture, and direct sunlight
Acute Toxicity (Oral, Rat): LD50 3500 mg/kg
Irritation: May cause skin and eye irritation, respiratory tract irritation in sensitive individuals
Sensitization: Prolonged or repeated exposure may cause allergic skin reactions
Chronic Effects: Long-term exposure not well studied; some sulfonamides linked with liver and kidney effects, blood disorders
Carcinogenicity: No classification by NTP, IARC, or OSHA
Mutagenicity: Data suggest low genotoxic risk; further studies required
Reproductive Toxicity: No known significant effects or critical hazards in standard use
Aquatic Toxicity: Toxic in high concentrations to aquatic organisms, may cause adverse effects to aquatic environments
Persistence and Degradability: Partial degradation in water and soil; not easily biodegradable
Bioaccumulative Potential: Low bioaccumulation expected based on chemical structure
Mobility in Soil: Moderate mobility due to water solubility
Other Adverse Effects: Possible impact on microbial communities in water treatment plants; avoid unnecessary release to environment
Waste Treatment Methods: Dispose of in accordance with local, regional, and national regulations.
Methods of Disposal: Collect and place in tightly sealed containers.
Chemical Waste: Contact licensed chemical disposal company; do not release to sewers or surface waters
Container Disposal: Rinse containers prior to recycling or recovery; follow all plans for hazardous material disposal
Regulatory Requirements: Adhere to hazardous waste regulations relevant to your jurisdiction
UN Number: Not classified as dangerous goods by UN/IMO/IATA regulations
Proper Shipping Name: Not regulated for transport
Hazard Class: Not assigned
Packing Group: Not required
Environmental Hazards: Avoid spillage into waterways and soil during transit
Special Precautions: Secure packaging and accurate labeling recommended to prevent accidental release
TSCA Inventory: Listed
EU Regulations: Listed on EINECS; subject to REACH obligations in Europe
OSHA Hazard Communication: Classified as hazardous according to OSHA 29 CFR 1910.1200
WHMIS Status (Canada): Class D2B (Toxic Material Causing Other Toxic Effects)
Other Regulations: Subject to safety and environmental laws; monitor updates from local regulatory agencies for compliance with use, handling, and disposal practices
