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Product Name: Selenoprotein
Chemical Family: Protein containing selenium
Synonyms: Selenium-containing protein, selenocysteine protein
Recommended Use: Research and industrial applications; not for food, drug, or household use
Supplier: Contact laboratory or commercial source for supplier details
Emergency Telephone Number: Local emergency services or poison control
Classification: Skin irritation, eye irritation, specific target organ toxicity (repeated exposure), aquatic toxicity
Hazard Symbols: Exclamation mark, environment
Signal Word: Warning
Hazard Statements: May cause skin and eye irritation, harmful if swallowed, potential long-term effects on organs due to selenium content, toxic to aquatic life
Precautionary Statements: Avoid ingestion and inhalation, prevent contact with skin and eyes, keep away from release into the environment, use protective equipment during handling
Chemical Name: Selenoprotein
CAS Number: 1306-23-6 (Selenium reference, actual selenoprotein CAS may vary)
Formula: Variable — protein backbone with selenium incorporated at selenocysteine residues
Impurities: Trace salts, buffer components, possible endotoxins from expression hosts
Concentration: Pure selenoprotein preparation, typical protein mass varies by source
Inhalation: Move person to fresh air; seek medical attention with any breathing difficulty
Skin Contact: Remove contaminated clothing, wash affected area with soap and water for several minutes, seek attention if irritation or rash appears
Eye Contact: Rinse cautiously with water for at least 15 minutes, lift eyelids to ensure flushing, remove contact lenses if present, seek medical advice immediately
Ingestion: Rinse mouth with water if substance eaten, do not induce vomiting, obtain medical help right away
Most Important Symptoms: Irritation, redness, possible selenium toxicity signs like gastrointestinal upset, garlic breath odor, fatigue
Suitable Extinguishing Media: Use dry chemical, CO₂, water spray, or foam for fires involving proteinaceous materials
Specific Hazards Arising: Product can generate oxides of selenium, irritating gases, and fumes under combustion
Protective Equipment: Firefighters use full protective gear and self-contained breathing apparatus to avoid inhalation
Special Procedures: Prevent runoff into water bodies, cool containers exposed to fire with water spray
Personal Precautions: Wear gloves, lab coat, face shield, and respiratory protection in case of dust or aerosols
Environmental Precautions: Contain spills, prevent product from reaching water channels or sewers
Spill Cleanup Methods: Absorb with inert material such as vermiculite; collect in closed, labeled waste containers; ventilate area and wash surfaces with appropriate cleaning agents
Handling: Use only in controlled environments such as laboratory fume hoods, keep containers sealed, avoid generating aerosols, use care to prevent spillage and accidental exposure
Storage: Store in tightly closed containers under refrigeration (2-8°C) if protein stability requires it, away from direct sunlight, acids, oxidizers, and incompatible chemicals; clearly label storage areas to prevent unintended use
Other Precautions: Restrict access to trained staff, maintain detailed inventory due to selenium’s potential hazards
Exposure Limits: Selenium compounds have recommended workplace exposure limits (OSHA PEL: 0.2 mg/m³ [as selenium])
Engineering Controls: Use local exhaust, laminar flow hoods, or glove boxes for manipulation of protein powders or large-scale preparations
Personal Protective Equipment: Safety goggles, disposable gloves (nitrile or latex), lab coats, and certified respirators when airborne particles pose a risk; change gloves frequently to avoid skin exposure
Hygiene Measures: Wash hands before breaks and after work, avoid eating or drinking in work areas, regularly clean work surfaces
Appearance: White to off-white lyophilized powder or solution (varies by preparation)
Odor: May have faint, protein-like odor and possible garlicky scent if selenium is in volatile state
pH (solution): Typically neutral to slightly alkaline, depending on storage buffer
Melting Point: Decomposes; not a defined melting point
Solubility: Soluble in water and dilute buffers, insoluble in nonpolar solvents
Boiling Point: Not applicable for proteins
Flash Point: Not readily flammable under normal laboratory conditions
Density: Often unmeasured for proteins, use as supplied
Partition Coefficient: Not relevant due to macromolecular nature
Chemical Stability: Stable under recommended storage range; protein may degrade at higher temperature, light, or pH extremes
Reactivity: Sensitive to oxidizing agents and acids
Hazardous Reactions: Protein can evolve toxic gases under high heat/combustion, reacts with strong oxidizers, may denature irreversibly outside storage conditions
Decomposition Products: Releases oxides of selenium, carbon monoxide, carbon dioxide, and nitrogen oxides when burned
Incompatibilities: Avoid acids, bases, oxidizers, heavy metal reagents
Acute Toxicity: Selenium in proteins presents acute oral and inhalation toxicity; symptoms might include gastrointestinal distress, dizziness, tremor; LD₅₀ for selenium varies by species/form
Chronic Toxicity: Repeated exposure could result in selenium accumulation, leading to selenosis (symptoms: hair loss, nail changes, neurological effects)
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Carcinogenicity: Selenium is neither confirmed as carcinogen nor classified as such by IARC, OSHA, NTP at low exposures typical in protein form
Mutagenicity/Reproductive Toxicity: No mutagenic or teratogenic effects known for selenoproteins at laboratory concentrations; high selenium is harmful in reproductive studies
Target Organs: Liver, kidneys, peripheral nerves (from selenium toxicity)
Toxicity to Aquatic Organisms: Highly toxic to aquatic life, even at low concentrations, selenium bioaccumulates and causes long-term ecosystem damage
Persistence/Degradability: Protein backbone may degrade naturally, selenium ions persist and can move through food webs
Bioaccumulation Potential: Documented bioaccumulation in aquatic animals; monitoring recommended for waste discharge
Mobility in Soil: Selenium can migrate through groundwater, contaminating soil, posing hazard to crops and animals
Other Harmful Effects: Accidental release or improper disposal contributes to regional selenium pollution, affecting wildlife and drinking water supplies
Waste Handling: Selenoprotein waste classifies as hazardous due to selenium content; segregate from regular biological waste
Disposal Method: Collect in leakproof, labeled containers and send for hazardous waste incineration or chemical treatment by approved contractor
Prevent Entry: Do not flush proteins or buffers containing selenium down drains; avoid landfill disposal
Container Decontamination: Deactivate residual protein with strong oxidants or alkali before container disposal; rinse containers in accordance with local guidelines
Regulatory Compliance: Follow EPA, local environmental, and institutional regulations for hazardous waste
UN Number: May not have a specific UN number if shipped as research sample; refer to regulations for selenium compounds
Shipping Name: Selenoprotein or Containing Selenium Commodity, research substance
Hazard Class: 6.1 (toxic substances) if classified under selenium salts or compounds
Packing Group: III (if classified under selenium compounds; confirm with shipment details)
Labeling: Toxic, environmental hazard pictograms
Transport Precautions: Use secondary containment, temperature control if needed; declare accurately on shipping forms; provide emergency response instructions with shipment
TSCA (Toxic Substances Control Act): Some selenoproteins may not be TSCA-listed as research products
SARA Title III: Selenium compounds reportable under SARA 313 (toxic chemical category)
OSHA: Considered hazardous under OSHA HazCom Standard due to toxicity class of selenium
REACH: Proteins for research may not require registration, selenium under restriction in many contexts
Other Regulations: Consult state and local rules as regulations for biological products vary, especially regarding hazardous waste and environmental discharges
Employee Protection: Training in handling hazardous research substances required for all personnel
Canadian WHMIS: Listed if containing enough selenium to pose a health risk
International Transport: Comply with IATA, IMDG, ADR codes for shipment of toxic substances
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
