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Product Name: Sarafloxacin hydrochloride
Chemical Family: Quinolone antibiotic
Synonyms: N-ethyl-6-fluoro-1,4-dihydro-7-(4-ethyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride
CAS Number: 91296-87-6
Intended Use: Veterinary antibacterial agent, aquaculture applications, research and laboratory procedures
Manufacturer Information: Manufacturer name, address, emergency contact telephone, customer service number
Recommended Restrictions: Not recommended for human use, avoid use in non-target organisms
Packaging: Sealed containers, moisture-proof, labeled for industrial use
GHS Classification: Acute toxicity (oral, dermal), Specific target organ toxicity (repeated exposure), Skin/eye irritation, Aquatic chronic toxicity
Signal Word: Warning
Hazard Statements: May cause allergy or asthma symptoms or breathing difficulties if inhaled; harmful if swallowed; may cause skin or respiratory irritation; suspected damage to fertility; may cause long lasting harmful effects to aquatic life
Precautionary Statements: Avoid skin contact, prevent inhalation, use suitable PPE, avoid release to environment, store locked up
Hazard Symbols: Exclamation mark, Health hazard, Environment
Routes of Exposure: Ingestion, inhalation, skin and eye contact
Potential Health Effects: Nausea, dizziness, allergic reaction, eye/skin irritation, respiratory tract irritation, possible liver or kidney impacts on repeated exposure
Chemical Name: Sarafloxacin hydrochloride
CAS Number: 91296-87-6
Content (%): >98% (active substance), small amounts of manufacturing impurities possible
Other Components: Trace residual solvents, non-active excipients as stabilizers or bulking agents depending on product formulation
Eye Contact: Rinse with plenty of water for at least 15 minutes, keeping eyelids open; remove contact lenses and seek medical attention if irritation persists
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing and footwear, seek medical advice if rash or irritation develops, launder clothes before reuse
Inhalation: Move to fresh air, keep at rest in a position comfortable for breathing, administer oxygen if breathing is difficult, consult a physician if symptoms persist
Ingestion: Rinse mouth with water, do not induce vomiting unless directed by medical personnel, give water to dilute, seek immediate medical assistance
Notes for Physician: Treat symptomatically, monitor for possible gastrointestinal and respiratory irritation, observe for delayed effects
Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, foam
Unsuitable Extinguishing Media: Direct water jet on burning powder
Specific Hazards: Combustion produces toxic nitrogen oxides, hydrogen chloride, carbon monoxide, carbon dioxide, fluorine gases
Protective Equipment: Wear self-contained breathing apparatus, full protective gear, prevent run-off from entering drains
Special Procedures: Move containers from fire area if possible without risk, cool fire-exposed containers with water mist, avoid inhaling smoke or combustion products
Personal Precautions: Wear appropriate PPE including gloves, goggles, mask or respirator, avoid creating dust, ventilate area
Environmental Precautions: Prevent chemical from entering drains, sewers, waterways; inform authorities if large spill occurs
Methods for Cleanup: Collect spilled material using non-sparking tools, dampen gently to reduce dust, transfer to labeled waste container, ventilate and wash affected area, dispose according to local regulations
Handling: Use with adequate ventilation, avoid inhalation and skin contact, do not eat, drink, or smoke when working with the product, use appropriate PPE such as gloves, goggles, lab coat, avoid generating airborne dust, wash hands after handling
Storage: Keep in tightly sealed containers under dry, cool conditions, protect from light and humidity, store away from incompatible substances such as oxidizers or strong acids, keep out of reach of untrained personnel and unauthorized access, label all containers clearly
Incompatible Materials: Strong oxidizers, reducing agents, acids, alkalis, moisture, metals that catalyze decomposition
Engineering Controls: Use local exhaust or general lab ventilation, containment booth or fume hood for large quantities
Exposure Limit Values: None established for Sarafloxacin; industry recommends keeping airborne concentrations as low as reasonably achievable
Respiratory Protection: NIOSH-approved particulate respirator when airborne dust or aerosols are likely
Hand Protection: Chemical-resistant nitrile or neoprene gloves
Eye/Face Protection: Chemical-splash safety goggles or face shield
Skin Protection: Laboratory coat, long sleeves, full-length pants, closed-toe shoes
Hygiene Measures: Wash hands before breaks and after work, change contaminated clothing, do not take contaminated clothing home
Form: Solid powder or crystalline substance
Appearance: White to pale yellow powder
Odor: Slightly characteristic
pH (1% solution): 3.5 - 5.0
Melting Point: 230–235°C (decomposition)
Boiling Point: Not applicable (decomposes)
Solubility: Freely soluble in water, sparingly soluble in methanol, slightly soluble in ethanol, practically insoluble in acetone and ether
Vapor Pressure: Negligible at room temperature
Relative Density: 1.65 g/cm³ (approximate)
Partition Coefficient: LogP 0.02 (octanol/water)
Other Data: Stable in closed containers below 40°C, hygroscopic in open air
Chemical Stability: Stable under recommended storage conditions, avoid excessive heat and light
Reactivity: Incompatible with strong acids, strong bases, oxidizing or reducing agents
Hazardous Reactions: Decomposition at high temperatures produces hazardous gases
Conditions to Avoid: Exposure to light, moisture, heat, ignition sources
Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide, fluorinated compounds
Polymerization: Will not occur under normal conditions
Acute Toxicity: Oral LD50 (rat) estimated 300–500 mg/kg; may cause nausea, vomiting, and diarrhea at lower exposures
Dermal Toxicity: Moderate irritant potential, possible absorption through skin contact
Inhalation: May irritate respiratory tract, coughing, headache, dizziness in sensitive individuals
Skin/Eye Contact: May provoke irritation, redness, allergic reactions or rash upon contact
Chronic Effects: Potential for organ toxicity with long-term exposure (liver, kidneys), possible reproductive and developmental effects in animals
Mutagenicity/Carcinogenicity: Not classified as carcinogenic to humans, but genotoxic effects observed in some non-mammalian study systems
Other Information: Sensitization reactions observed in laboratory animals, risk for aquatic organisms from small residues
Ecotoxicity: Harmful to aquatic life, moderate bioaccumulation potential, persistence in sediments and water
Mobility in Soil: Moderate to low mobility, potential leaching from aquaculture runoff
Persistence/Degradability: Biodegrades slowly, resistant to photolysis, half-life in water several weeks
Bioaccumulative Potential: Accumulates in aquatic organisms, risk of secondary poisoning up food chain
Other Adverse Effects: Toxic to algae, invertebrates, and fish at low concentrations, disrupts aquatic ecosystems
Product Disposal: Dispose as hazardous chemical waste, follow local, regional, national disposal regulations
Container Disposal: Triple-rinse containers, puncture to prevent reuse, dispose according to government requirements
Sewage Disposal: Avoid release to wastewater systems or open environment
Recommended Methods: Incineration in licensed facility with flue-gas scrubbers, secure landfill for non-burnable residues
Precautions: Do not mix with incompatible materials, keep waste isolated from watercourses and soil
UN Number: Not assigned for Sarafloxacin; shipping must comply with local hazardous material codes
Proper Shipping Name: Chemical, solid, n.o.s. (contains Sarafloxacin hydrochloride)
Transport Hazard Class: Not classified under DOT, ADR, IMDG for most finished forms
Packing Group: III (if applicable for large shipments)
Environmental Hazards: Marine pollutant; mark and segregate aquatic hazards in bulk shipments
Special Precautions: Avoid moisture, strong oxidizers, incompatible substances; transport in sealed, secure, labeled containers with documentation
Regulatory Compliance: Product subject to regulation under veterinary medicine and chemical safety laws
OSHA: Not specifically regulated in the USA, but use falls under Hazard Communication Standard
REACH (EU): Registration required for significant imports; subject to chemical safety assessment
TSCA: Not listed as a commercial chemical in the United States
Other Country Laws: Listed under local regulations governing antimicrobial discharge and pharmaceutical use in animals; some bans/restrictions apply in aquaculture
Other Protein Residue Legislation: Maximum residue limits (MRLs) established for food-producing animals; environmental impact subject to periodic review and restriction in major producing countries
