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Saccharin Material Safety Data Sheet

Identification

Product Name: Saccharin Sodium
Chemical Name: 1,2-benzisothiazol-3(2H)-one, 1,1-dioxide, sodium salt
Chemical Formula: C7H4NO3SNa
CAS Number: 128-44-9
EC Number: 204-886-1
Synonyms: Sodium saccharin, Benzoic sulfimide
Recommended Uses: Non-nutritive sweetener for food and beverages, used in tabletop sweeteners and some pharmaceuticals
Supplier/Manufacturer: Contact information required on-site based on local availability
Emergency Phone Number: Local emergency service information relevant to jurisdiction

Hazard Identification

Classification: Not classified as hazardous under GHS criteria for most regions, but local regulations may apply
Label Elements: No pictogram or signal word required by GHS
Hazard Statements: May cause mild eye and skin irritation, ingestion in high amounts may lead to digestive upset, possible allergic reactions in sensitive individuals
Precautionary Statements: Avoid dust inhalation, wash skin thoroughly after handling, use in well-ventilated area
Potential Health Effects: Inhalation irritates respiratory tract, contact can irritate eyes or skin, ingestion in normal quantities for food is considered safe, excessive exposure can affect gut flora in certain cases
Environmental Hazards: Not expected to produce acute hazards, persistent in aquatic environments

Composition / Information on Ingredients

Ingredient: Sodium Saccharin
Chemical Formula: C7H4NO3SNa
Concentration: Above 98% purity
Impurities: Trace sodium chloride, water less than 2%, other trace inorganics
Additional Components: Usually none, occasionally contains anticaking agent with food-grade certification

First Aid Measures

Eye Contact: Rinse immediately with gentle stream of cool water for at least 15 minutes, lift eyelids to ensure thorough flushing, seek medical advice if irritation continues
Skin Contact: Remove contaminated clothing, wash skin with soap and clean water, seek attention if irritation or rash develops
Inhalation: Move person to fresh air, get comfortable, monitor for symptoms such as coughing or throat irritation, seek support if symptoms persist
Ingestion: Rinse mouth with water, drink water to aid dilution, do not induce vomiting, seek medical guidance if large quantities believed to be swallowed
Note to Physician: Treat symptomatically, monitor for allergic reaction in sensitive individuals

Fire-Fighting Measures

Suitable Extinguishing Media: Use standard foam, CO2, dry powder, or water spray for surrounding fires
Specific Hazards: Saccharin itself is not readily combustible, dust may form explosive mixture with air under rare conditions
Hazardous Combustion Products: May emit sulfur oxides, nitrogen oxides, sodium oxides, carbon oxides when heated to decomposition
Advice for Firefighters: Wear full protective clothing and self-contained breathing apparatus, avoid inhaling combustion fumes
Special Protective Equipment: Impermeable gloves, chemical splash goggles

Accidental Release Measures

Personal Precautions: Avoid creating dust, provide ventilation, use eye protection and gloves when cleaning up
Spill Containment: Sweep up or vacuum material to avoid dust dispersal, place in labelled containers for proper disposal
Environmental Precautions: Prevent entry into waterways, soil, or drains, avoid contamination of natural water sources
Cleanup Methods: Use non-sparking tools, collect spilled material in containers for reuse or disposal, ventilate area after cleanup

Handling and Storage

Precautions for Safe Handling: Minimize dust generation and accumulation, avoid contact with eyes and skin, use local exhaust when necessary
Storage Conditions: Store in cool, dry, well-ventilated area away from moisture and incompatible materials, keep tightly closed in original container
Incompatible Materials: Avoid strong oxidizers, acids, and bases, store separate from incompatible substances
Hygiene Measures: Wash hands after handling, do not eat or drink during handling, follow food safety protocols if used in food manufacturing

Exposure Controls and Personal Protection

Engineering Controls: Use local exhaust or general ventilation to minimize dust inhalation
Exposure Limits: No established occupational exposure limit for saccharin, follow standard dust exposure limits (OSHA PEL, ACGIH TLV for nuisance dust)
Personal Protective Equipment:
- Eyes:
Safety glasses with side shields
- Skin: Protective gloves recommended for prolonged contact
- Respiratory: Dust mask (N95 or equivalent) if dust becomes airborne
- Clothing: Standard laboratory coats, protective footwear

Physical and Chemical Properties

Appearance: White crystalline powder
Odor: Odorless or slightly sweet
Melting Point: 228–229°C (decomposes)
Boiling Point: Not applicable (decomposes)
Solubility: Freely soluble in water
pH: 6.5–7.5 (1% aqueous solution)
Vapor Pressure: Negligible
Partition Coefficient (log Kow): -2.13
Flash Point: Not applicable
Explosive Properties: Dust may present explosion hazard in rare airborne concentrations
Density: Approximately 0.9–1.1 g/cm³

Stability and Reactivity

Chemical Stability: Stable under normal conditions of use and storage
Hazardous Reactions: Avoid strong acids, strong bases, and oxidizing agents, these interactions can trigger decomposition
Decomposition Products: May release toxic fumes including sulfur oxides, nitrogen oxides, sodium oxides, and carbon oxides if burned
Conditions to Avoid: Prolonged heat, moisture exposure, incompatible chemicals
Polymerization: Does not occur

Toxicological Information

Acute Toxicity: Rat oral LD50 above 17,000 mg/kg, not considered acutely toxic at common exposure levels
Skin Irritation: Not classified as a skin irritant, rare allergic contact dermatitis reported
Eye Irritation: Mild irritation possible with direct exposure
Inhalation: Inhalation of dust may cause coughing or mild respiratory irritation
Sensitization: Rare cases of sensitivity, more common in workers with chronic exposure
Chronic Toxicity: No definitive evidence of carcinogenicity in humans, classified as generally recognized as safe for human use in controlled amounts by international agencies
Other Effects: Large quantities may disrupt gut microflora, not recommended for those with specific sulfa drug allergies

Ecological Information

Ecotoxicity: Saccharin demonstrates low toxicity to fish and aquatic invertebrates at concentrations found in wastewater
Persistence and Degradability: Persists in surface waters, partial biodegradability reported
Bioaccumulation Potential: Low, does not significantly accumulate in organisms
Mobility in Soil: Mobile in water, risk to groundwater minimal under normal use scenarios
Other Adverse Effects: No significant adverse effects demonstrated in current environmental studies

Disposal Considerations

Waste Disposal Methods: Dispose excess or spilled material according to local, regional, or national requirements, preferred disposal via landfill or incineration under controlled conditions
Container Disposal: Rinse thoroughly, dispose as non-hazardous material if free from major contamination
Environmental Precautions: Do not discharge into drains, natural water sources, or soil without proper treatment

Transport Information

UN Number: Not regulated as a dangerous good in transport
Transport Hazard Class: None
Packing Group: Not assigned
Proper Shipping Name: Saccharin Sodium
Environmental Hazards: Not classified as a marine pollutant
Special Precautions: Protect packages from moisture and high humidity during transit, avoid breakage and leakage

Regulatory Information

Food Additive Status: Approved as a food additive in many countries, subject to local regulatory authority guidelines
TSCA: Listed on the Toxic Substances Control Act Inventory (United States)
EU EINECS: Listed on European Inventory of Existing Commercial Substances
International Agency for Research on Cancer (IARC): Not classifiable as carcinogenic to humans; evidence from animal data not considered relevant at dietary exposure levels
Other Regulations: Subject to restrictions for maximum allowable amounts in food and beverages, regular monitoring by FDA, EFSA, and other food safety authorities