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Product Name: Retinol Acetate
Synonyms: Vitamin A Acetate, All-Trans Retinol Acetate
Chemical Formula: C22H32O2
Molecular Weight: 328.49 g/mol
CAS Number: 127-47-9
Recommended Use: Analytical reagent, cosmetic ingredient, food additive, vitamin supplement
Manufacturer: Identify company details and emergency contact information
Contact Number: Specific to supplier or manufacturer
Address: Manufacturer’s registered address
Hazard Classification: Eye irritation category 2A, Skin irritation category 2, Specific organ toxicity—repeated exposure category 2
GHS Label Elements: Exclamation mark pictogram, signal word: Warning
Hazard Statements: May cause moderate eye irritation, causes mild skin irritation, toxic if ingested in large amounts; may harm liver with prolonged exposure
Precautionary Statements: Avoid direct contact with eyes or skin, do not eat, drink, or smoke during use, wash hands thoroughly after handling
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Symptoms: Redness, tearing, scaling of skin, abdominal pain, headache, dizziness
Target Organs: Skin, eyes, liver, central nervous system
Chemical Name: Retinol Acetate
Concentration: Greater than 97% purity
Impurities: Trace stabilizers or antioxidants used in manufacturing; identify if present with concentrations
Other Components: Residual solvents or byproducts in negligible quantity
CAS Number: 127-47-9
Inhalation: Move person to fresh air, monitor for breathing difficulty, seek medical advice if symptoms persist
Skin Contact: Remove contaminated clothing, wash skin with mild soap and water for several minutes, seek medical attention for persistent irritation
Eye Contact: Rinse eyes with plenty of tepid water for at least 15 minutes, lift eyelids during rinsing, seek ophthalmological advice if discomfort or visual changes remain
Ingestion: Do not induce vomiting, rinse mouth with water, consult a physician immediately, show this safety data sheet
Most Important Symptoms: Overexposure can cause skin dryness, gastrointestinal discomfort, dizziness
Immediate Medical Care: Administer supportive measures based on symptoms, no known antidote
Flammable Properties: May burn if heated or exposed to flame, moderate fire hazard
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray
Specific Fire Hazards: During fire, toxic and irritating vapors such as carbon monoxide and carbon dioxide may form
Protective Equipment: Firefighters must use self-contained breathing apparatus and full protective gear
Special Procedures: Keep containers cooled by water spray, control run-off water to avoid environmental contamination
Explosion Sensitivity: Not expected to present explosion hazard in solid state but avoid dust formation which can potentially ignite under strong ignition source
Personal Protection: Wear suitable chemical-resistant gloves, safety goggles, and lab coat; avoid inhalation of dust, ventilate area
Spill Cleanup Procedure: Use inert absorbent material (such as sand or vermiculite) to collect spilled product, sweep carefully to prevent dust generation, place into properly labeled waste container
Environmental Precautions: Prevent material from entering drains, sewers, or waterways
Decontamination: Rinse spill site with water following material pick-up; dispose contaminated cleaning materials according to local, state, and federal requirements
Safe Handling Advice: Use only in well-ventilated areas, avoid direct skin and eye contact, do not breathe dust, use appropriate PPE and follow standard lab hygiene
Storage Conditions: Store in original tightly closed container, keep in a cool, dry, well-ventilated place out of direct sunlight, protect from heat, moisture, and incompatible materials like strong acids or oxidizers
Temperature Recommendations: Maintain below 25ºC, or follow manufacturer's specific guidelines for stability
Packaging Materials: Use containers made of compatible material such as amber glass or high-density polyethylene, keep away from food and beverages
Control Parameters: No established OSHA, ACGIH, or NIOSH limits for pure retinol acetate
Engineering Controls: Chemical fume hood or local exhaust in areas with significant dust or aerosol generation
Personal Protection: Chemical safety goggles, nitrile gloves, long-sleeved lab clothing, dust mask or approved respirator if dusty conditions prevail
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing before entering eating or break areas, replace protective clothing as needed
Appearance: Yellow to orange crystalline powder
Odor: Slight, characteristic
Melting Point: 57 - 58.5°C
Boiling Point: Decomposes before boiling
Solubility: Soluble in ethanol, chloroform, ether, fats, oils; insoluble in water
Density: Approximately 1.03 g/cm³
pH: Not applicable (insoluble in water)
Partition Coefficient: Log Kow estimated at 6.7 (highly lipophilic)
Vapor Pressure: Negligible at room temperature
Flash Point: Not readily available, expect above 100°C
Auto-ignition Temp: Not identified
Evaporation Rate: Not applicable
Chemical Stability: Stable under recommended storage conditions, especially in the absence of light and air
Reactivity: May react with strong oxidizing agents, acids, bases
Decomposition Products: On heating or combustion, will yield irritating, toxic fumes of carbon oxides
Polymerization: Not known to occur
Other Information: Light, heat, and air accelerate degradation; always store protected from these conditions
Acute Toxicity: Oral LD50 (rat) estimated at 5,000 mg/kg, but large doses can cause symptoms of hypervitaminosis A
Short-Term Exposure: Irritation to eyes, skin, and mucous membranes; ingestion leads to nausea, vomiting, headache, irritability
Chronic Effects: Repeated overexposure may produce dry, cracked skin, bone pain, liver toxicity, teratogenic effects in pregnant individuals
Carcinogenicity: No recognized carcinogenic potential by IARC, NTP, OSHA
Mutagenicity: No strong evidence for genotoxicity or mutagenic effects in standard tests
Reproductive Effects: High-dose exposure in animals linked to birth defects and reproductive toxicity
Sensitization: Not commonly associated with sensitization, but individual hypersensitivity possible
Ecotoxicity: Large releases may harm aquatic organisms due to potential bioaccumulation and lipophilicity
Persistence and Degradability: Not easily degradable in the environment, stable in absence of light
Bioaccumulation Potential: High, due to fat solubility (partitioning into biological membranes)
Mobility: Tends to bind to soil and particulate matter rather than migrate into groundwater
Aquatic Toxicity: Data limited for pure retinol acetate; extrapolation from related compounds indicates risk to aquatic life in excess
Other Comments: Avoid uncontrolled release into the environment
Waste Treatment Methods: Dispose of in accordance with local, state, and federal regulations; incineration preferred in permitted facility
Container Disposal: Decontaminate and dispose of containers as hazardous waste; do not reuse containers for other purposes
Precautions: Do not allow spillage to contaminate soil, groundwater, or watercourses
Disposal Practices: Use sealed, labeled waste containers; alert waste handler to presence of vitamins, treat as chemical waste
UN Number: Not regulated as hazardous for road, rail, air, or sea transport under common global standards
Proper Shipping Name: Not classified as dangerous
Hazard Class: None assigned under DOT, IMDG, IATA
Packing Group: None
Special Precautions: Protect from direct sunlight, moisture, and physical damage; ensure containers remain sealed and secure during transit
Transport Label: Not required unless shipped in quantities or forms triggering specific national or international rules
Safety, Health, and Environmental Regulations: Not specifically listed under US TSCA, Canadian DSL, EU REACH for hazardous substance controls
Labelling Requirements: Standard workplace labels apply, GHS recommended
Right-to-Know Components: Not listed on California Proposition 65; confirm status with local regulators
Other Regulations: Consult national and local authorities for end-use or limits regarding vitamins in foods and cosmetics, occupational controls apply; observe relevant codes for chemical substances at place of use
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
