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Material Safety Data Sheet: Propyl Gallate

Identification

Product Name: Propyl Gallate
Chemical Formula: C10H12O5
Synonyms: n-Propyl gallate, Propyl 3,4,5-trihydroxybenzoate
CAS Number: 121-79-9
Recommended Use: Antioxidant for food, cosmetics, pharmaceuticals
Supplier Details: Manufacturer and distributor information should be referenced from the supplier’s label or safety documentation
Emergency Contact: Reference emergency contacts provided by supplier or local emergency service

Hazard Identification

Hazard Classification: Not classified as hazardous per GHS standards in most regions, though it can be harmful if swallowed or inhaled in large amounts
Physical Hazards: No significant physical risk under ambient conditions, fire risk possible if stored with incompatible materials
Health Hazards: Can cause skin and eye irritation, potential allergen, respiratory symptoms may develop after prolonged inhalation exposure
Environmental Hazards: May be harmful to aquatic life with long-lasting effects
Label Elements: Avoid contact with skin and eyes, do not inhale dust, use personal protection

Composition / Information on Ingredients

Chemical Name: Propyl Gallate
Percentage: 99-100%
CAS Number: 121-79-9
Impurities: Trace organic compounds, amounts below threshold for disclosure
Molecular Weight: 212.21 g/mol
EINECS Number: 204-498-2

First Aid Measures

Inhalation: Remove person to fresh air, monitor for persistent symptoms like coughing or shortness of breath, seek medical attention if necessary
Skin Contact: Wash area thoroughly with mild soap and water, remove contaminated clothing, medical advice if irritation appears
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if easy to do, continue rinsing and get medical help if discomfort persists
Ingestion: Rinse mouth with water, do not induce vomiting, get immediate medical care if large amounts ingested
Potential Symptoms: Redness, itching, irritation to mucous membranes, headache if inhaled, nausea if swallowed

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical, CO2, foam, water spray
Unsuitable Extinguishing Media: Direct water stream—may spread burning powder
Specific Hazards: May form toxic fumes of carbon monoxide and carbon dioxide during combustion
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Special Precautions: Cool containers exposed to flame with water spray from a safe distance, avoid inhalation of combustion products

Accidental Release Measures

Personal Protection: Use gloves, eye protection, dust mask or respirator, avoid creating airborne dust
Spill Containment: Sweep or shovel solids into a designated, labeled container—minimize dust generation
Environmental Precautions: Prevent releases to drains, surface water, and soil—report uncontrolled releases to authorities
Cleanup: Wash spill site with plenty of water after material pickup, ventilate area, dispose of waste materials according to local regulations

Handling and Storage

Handling Precautions: Avoid skin and eye contact, avoid breathing dust, use appropriate exhaust ventilation in work areas
Storage Conditions: Store in tightly closed container, in a cool, dry, well-ventilated location, away from direct sunlight and incompatible materials like strong oxidizers
Incompatibilities: Avoid contact with strong acids, bases, oxidizing agents
Hygiene Measures: Wash hands thoroughly after handling, remove and wash contaminated clothing before reuse, keep food and beverages away from work area

Exposure Controls and Personal Protection

Control Parameters: Occupational exposure limits not established, though general dust limits may apply in some jurisdictions
Engineering Controls: Use local exhaust or general dilution ventilation—keep airborne concentrations below acceptable limits
Personal Protective Equipment: Safety goggles, chemical-resistant gloves, protective clothing, appropriate respirator under dusty conditions
Work Practices: Keep work area clean, use methods that minimize dust generation, wash thoroughly after handling

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: 148–150°C
Boiling Point: Decomposes prior to boiling
Solubility: Slightly soluble in water, freely soluble in ethanol, ether, and oils
pH (solution): No significant pH shift in water due to low solubility
Flash Point: >110°C (closed cup)
Flammability: May burn at high temperatures
Density: 1.19 g/cm³
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log Kow): 1.8

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions
Reactivity: Not reactive under normal handling and storage
Incompatible Materials: Strong oxidizing agents, strong acids, alkalis
Decomposition Products: Carbon dioxide, carbon monoxide, phenolic compounds at high temperatures
Hazardous Polymerization: Does not occur

Toxicological Information

Acute Toxicity (oral): LD50 (rat) ~3800 mg/kg
Acute Toxicity (dermal): LD50 not well established, low skin absorption expected
Skin Corrosion/Irritation: May cause mild irritation with direct, prolonged contact
Eye Damage/Irritation: May cause irritation with redness or tearing
Respiratory Sensitization: Not expected to be a respiratory sensitizer, but fine dust inhalation may cause mild symptoms
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA
Mutagenicity: No evidence of mutagenic effects at typical exposure levels
Other Data: Allergic reactions possible in sensitive individuals, not known to bioaccumulate significantly

Ecological Information

Ecotoxicity: May be toxic to fish and aquatic invertebrates at high concentrations
Persistence and Degradability: Readily biodegradable under aerobic conditions
Bioaccumulative Potential: Low, predicted log Kow indicates limited bioaccumulation
Mobility in Soil: Not highly mobile, may adsorb to soil particles
Other Adverse Effects: Chronic exposure could disturb aquatic environments, keep away from waterways and soil

Disposal Considerations

Disposal Methods: Collect and place in tightly sealed containers, deliver to authorized chemical waste disposal firm
Contaminated Packaging: Decontaminate and recycle or dispose of according to regulations
Flush Residues: Avoid direct release into sewage or watercourses
Local Regulations: Dispose of according to local, regional, state, and national legal requirements
Advice: Seek advice from waste disposal professionals familiar with local hazardous waste laws

Transport Information

UN Number: Not regulated for transportation
Proper Shipping Name: Propyl Gallate
Hazard Class: Not classified as a dangerous good
Packing Group: Not assigned
Special Precautions: Prevent container damage and contamination, use standard protection against dust
Environmental Hazards: Not subject to Marine Pollutant requirements

Regulatory Information

Labeling: Complies with food safety, pharmaceutical and cosmetic regulations where permitted—verify with country-specific authorities
Chemical Inventory Status: Listed on TSCA, EINECS, DSL, AICS
Workplace Safety: Subject to workplace safety legislation regarding handling powdered chemicals and potential allergens
Occupational Health: General requirements for chemical hygiene and personal protective use apply
Regulatory References: Confirm coverage under local regulations, including REACH (EU), OSHA (US), WHMIS (Canada)