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Product Name: Praziquantel
Chemical Name: 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one
SYNONYMS: Biltricide, Droncit, Cesol
CAS Number: 55268-74-1
Recommended Use: Anthelmintic for the treatment of parasitic worm infections
Supplier Details: Manufacturer or supplier details available on product packaging
Emergency Contact: Emergency phone number listed on label or related documentation
GHS Classification: Not classified as hazardous under GHS guidelines in most jurisdictions
Signal Word: None required
Hazard Statements: May cause mild skin and eye irritation with prolonged exposure. Minimal risk through inhalation or ingestion in occupational settings.
Precautionary Statements: Use eye and hand protection. Wash hands after handling. Avoid dust formation.
Chemical Identity: Praziquantel
CAS Number: 55268-74-1
Concentration: 100% pure substance for bulk or raw form; pharmaceutical formulations may contain excipients and binders
Impurities: Trace organic solvents or residues from synthesis, negligible in finished pharmaceuticals
Eye Contact: Rinse eyes with plenty of water holding eyelids apart. Seek medical attention if irritation persists.
Skin Contact: Wash affected area with water and mild soap. Remove contaminated clothing.
Inhalation: Move person to fresh air. Provide oxygen if breathing becomes difficult.
Ingestion: Rinse mouth, do not induce vomiting unless directed by medical personnel. Seek medical attention for symptoms.
Suitable Extinguishing Media: Water mist, dry chemical powder, carbon dioxide, or alcohol-resistant foam
Unsuitable Media: Do not use strong water jets as they spread powder
Hazardous Combustion Products: Carbon monoxide, nitrogen oxides, other unidentified organics may form
Protective Equipment: Wear self-contained breathing apparatus and full protective suit
Special Information: Containers near fire should be cooled with water
Personal Precautions: Avoid dust inhalation. Wear gloves, goggles, masks.
Environmental Precautions: Prevent entry into drains and waterways.
Clean-up Methods: Sweep up without generating dust, transfer to suitable container. Wash spill site with water after material pickup is complete.
Handling: Avoid contact with skin and eyes. Wear personal protective equipment. Prevent dust formation. Use only in well-ventilated areas.
Storage: Store in a cool, dry, well-ventilated space. Keep container tightly closed and away from incompatible materials such as strong oxidizers, acids, and bases. Avoid direct sunlight and excessive heat.
Control Parameters: Occupational exposure limits not established; minimize exposure as per general good practice.
Engineering Controls: Use adequate ventilation or local exhaust. Protective screens or barriers may help in large scale handling.
Personal Protective Equipment: Safety glasses, gloves, lab coat, dust mask if handling powders, no eating or drinking in work area.
Hygiene Measures: Wash hands after handling and before eating or smoking.
Appearance: White to off-white crystalline powder
Odor: Odorless or slight characteristic odor
pH: Not applicable (insoluble in water)
Melting Point: 136 – 140°C
Boiling Point: Decomposes before boiling
Solubility: Slightly soluble in water, freely soluble in alcohol and chloroform
Density: Approx. 1.3 g/cm³
Vapor Pressure: Not significant at room temperature
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not reactive under normal use
Hazardous Reactions: No hazardous polymerization
Incompatibilities: Strong oxidizing agents, acids, bases
Decomposition Products: Releases carbon monoxide, nitrogen oxides at high temperatures
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: LD50 oral (rat): 2840 mg/kg
Chronic Effects: No evidence of carcinogenicity or mutagenicity in animal studies.
Symptoms: Mild gastrointestinal discomfort, headache, dizziness, skin or eye irritation
Sensitization: Low potential for skin sensitization under normal conditions
Environmental Fate: Not readily biodegradable
Aquatic Toxicity: Harmful to aquatic organisms
Mobility in Soil: Low mobility due to limited solubility in water
Bioaccumulation: Potential for bioaccumulation exists, though relatively low
Persistence: Can persist in aquatic systems, consider minimizing runoff and release into the environment
Waste Disposal Methods: Dispose according to local, regional, national regulations. Incinerate or landfill only in approved facilities.
Contaminated Packaging: Triple rinse and offer for recycling or reconditioning; dispose per local requirements.
UN Number: Not regulated as hazardous for transportation
Proper Shipping Name: Praziquantel
Transport Hazard Class: Not classified
Packing Group: None
Special Precautions: Ship in sealed containers, protect from physical damage, avoid excessive heat and moisture
TSCA: Listed
US EPA: Not regulated as hazardous
EU Regulations: Listed in EINECS/ELINCS
OSHA Status: Not classified as hazardous
WHMIS Status (Canada): Not controlled
Other Information: Product intended for pharmaceutical and veterinary use, subject to regulatory oversight for use and labeling
