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Material Safety Data Sheet - Polyvinylpyrrolidone

Identification

Chemical Name: Polyvinylpyrrolidone
Synonyms: Povidone, PVP, Polyvidone
CAS Number: 9003-39-8
Recommended Use: Pharmaceutical binder, thickener in cosmetics, stabilizer in food and technical processes
Manufacturer Information: Common manufacturers include Ashland, BASF, and Sigma-Aldrich. Contact details provided on purchase order or product label.
Emergency Contact: ChemTrec or International Poison Control, numbers vary by region
Restrictions: Not intended for ingestion in industrial settings; handle as a chemical compound.

Hazard Identification

GHS Classification: Not classified as hazardous under GHS
Signal Word: None
Hazard Statements: Dust may cause temporary irritation to eyes, skin, or respiratory tract.
Hazard Pictograms: None required
Precautionary Statements: Avoid breathing dust, avoid contact with eyes and prolonged skin exposure. Wash hands thoroughly after handling. Use only with adequate ventilation.

Composition / Information on Ingredients

Main Ingredient: Polyvinylpyrrolidone, concentration varies depending on manufacturer
Impurities: May contain low levels of monomer residue, water, sodium lauryl sulfate (trace process aid), and proprietary stabilizers
Other Hazardous Ingredients: None typically present in notable concentrations
Formulation Notes: Often sold as powder or aqueous solution, check product specification for exact content

First Aid Measures

Inhalation: Move affected person to fresh air. Seek medical attention if breathing becomes difficult or if symptoms persist.
Skin Contact: Wash skin with plenty of water and mild soap. Remove contaminated clothing. If irritation develops or persists, get medical advice.
Eye Contact: Rinse eyes cautiously with water for several minutes. Remove contact lenses if present and easy to do so. Continue rinsing. Seek medical advice if irritation persists.
Ingestion: Rinse mouth with water. Seek medical advice if feeling unwell or if a large quantity was swallowed.
Notes for Physicians: Treat symptomatically, there is no known specific antidote for polyvinylpyrrolidone exposure.

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, foam, carbon dioxide, or dry chemical powder
Unsuitable Extinguishing Media: High-pressure water jets may spread dust
Fire and Explosion Hazards: Fine dust can form explosive mixtures with air. Burning may produce carbon oxides and nitrogen oxides.
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear.
Advice: Move containers from fire area if it can be done without risk. Cool containers exposed to heat with water spray.

Accidental Release Measures

Personal Precautions: Avoid inhalation of dust, use protective equipment including gloves and safety goggles. Ensure adequate ventilation.
Environmental Precautions: Prevent further leakage or spillage. Do not discharge large quantities directly into drains or watercourses.
Methods for Cleaning Up: Scoop up bulk material, place in labeled waste container. Avoid creating dust. Use damp methods or vacuum approved for dust collection. Dispose of in accordance with local regulations.

Handling and Storage

Safe Handling: Avoid dust formation. Do not breathe dust. Use in well-ventilated areas. Wear suitable protective equipment.
Hygiene Measures: Wash hands thoroughly after handling. Do not eat, drink, or smoke when using this product.
Storage Conditions: Store in tightly closed containers. Keep dry and away from sources of moisture and incompatible substances. Avoid extreme heat and direct sunlight.
Incompatible Materials: Strong oxidizing agents, strong acids; avoid prolonged contact with moisture as clumping can occur.

Exposure Controls and Personal Protection

Exposure Limits: No established occupational exposure limits for polyvinylpyrrolidone. Use natural or mechanical ventilation to control exposure.
Engineering Controls: Use local exhaust ventilation or general room ventilation to minimize dust concentrations.
Personal Protective Equipment:
Respiratory Protection: N95 or P2 particulate respirator if dust is generated.
Hand Protection: Chemical-resistant gloves such as nitrile or latex.
Eye Protection: Safety goggles or face shield.
Skin Protection: Lab coat or protective clothing. Wash all protective gear after use.

Physical and Chemical Properties

Appearance: White to off-white powder or colorless to pale yellow solution
Odor: Slight, characteristic
Odor Threshold: Not determined
pH (1% solution): 3.0 – 7.0
Melting Point: >300°C (decomposes)
Boiling Point: Not applicable (polymer)
Flash Point: Not determined
Evaporation Rate: Not applicable
Flammability: Not classified as flammable, but dusts may be combustible
Vapor Pressure: Not applicable
Solubility: Freely soluble in water, insoluble in most organic solvents
Density: Around 1.1–1.3 g/cm³
Partition Coefficient (n-octanol/water): Not determined
Viscosity: Dependent on grade and concentration
Decomposition Temperature: >200°C, decomposition may produce toxic gases.

Stability and Reactivity

Stability: Stable under normal use and storage conditions.
Reactivity: No dangerous reactions known under recommended conditions.
Conditions to Avoid: Excess moisture, excessive heat, ignition sources
Incompatible Materials: Strong oxidizers and strong acids.
Hazardous Decomposition: Thermal decomposition may produce carbon monoxide, carbon dioxide, nitrogen oxides.
Polymerization: Not known to occur under normal conditions.

Toxicological Information

Acute Toxicity: Oral LD50 in rats >10000 mg/kg (practically non-toxic)
Skin Corrosion/Irritation: Not expected to cause skin irritation with short-term exposure
Eye Damage/Irritation: Dust may cause mechanical irritation
Respiratory Sensitization: Repeated inhalation may cause mild irritation
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA
Reproductive Toxicity: Studies do not indicate reproductive or developmental effects
Chronic Effects: No significant long-term effects noted from occupational exposure
Additional Information: Allergic reactions possible, though rare. Povidone has a well-documented safety profile in pharmaceuticals and food.

Ecological Information

Ecotoxicity: No significant toxicity to aquatic life observed under normal conditions
Persistence and Degradability: Polyvinylpyrrolidone is non-biodegradable under standard biological treatment conditions
Bioaccumulation Potential: Low; not expected to bioaccumulate
Mobility in Soil: Highly soluble, likely to migrate through soil with water
Other Adverse Effects: Large quantities may lead to increased chemical oxygen demand in water systems. Not considered a major environmental threat when used properly.

Disposal Considerations

Waste Treatment Methods: Dispose as non-hazardous organic solid waste in accordance with local, state, and federal regulations
Preferred Disposal: Incineration or landfill after neutralization, as per facility guidelines
Contaminated Packaging: Rinse containers thoroughly before recycling or disposal
Disposal Notes: Do not pour large amounts into sewer systems or water bodies. Notify relevant authorities if disposal circumstances fall outside routine waste management.

Transport Information

UN Number: Not regulated for transport
UN Proper Shipping Name: Not regulated as dangerous goods
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Marine Pollutant: No
Special Precautions: Secure containers during transit to prevent breakage and dust dispersal
Transport Labeling: No specific label required for road, rail, sea, or air shipments.

Regulatory Information

US TSCA Status: Listed
EU REACH Registration: Registered polymers, specific monomers or impurities may be listed
Canada DSL/NDSL: Listed
OSHA HazCom 2012: Not considered hazardous
SARA 311/312 Hazards: Not reportable
California Prop 65: Not listed
Other Regulations: Listed in the pharmacopoeias (USP, Ph.Eur), permissible in food (as a processing aid, E1201 in EU), subject to good manufacturing practices in all applications.
Local Regulations: Users should consult local regulatory authorities to ensure compliance based on use and volume.