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Polyvinylpolypyrrolidone Material Safety Data Sheet (MSDS)

Identification

Product Name: Polyvinylpolypyrrolidone
Chemical Name: Crosslinked Polyvinylpyrrolidone
CAS Number: 25249-54-1
Recommended Uses: Pharmaceutical excipient, beverage clarifier, technical adsorbent
Supplier Details: Contact information of manufacturer or supplier including address, phone number, and emergency contact
Molecular Formula: (C6H9NO)n
Synonyms: PVPP, Crospovidone

Hazard Identification

Classification: Not classified as hazardous under GHS criteria
Health Hazards: Inhalation may cause respiratory irritation or coughing; dust particles can irritate eyes and skin
Environmental Hazards: Not expected to present significant environmental danger
Physical Hazards: Fine powder can create dust explosion hazard in air when accumulated
GHS Label Elements: Does not require hazard pictograms or signal word
Precautionary Statements: Avoid breathing dust; avoid contact with eyes and skin; wash hands thoroughly after handling

Composition / Information on Ingredients

Chemical Identity: Polyvinylpolypyrrolidone
CAS Number: 25249-54-1
Concentration: ≥ 99%
Impurities or Stabilizers: No significant impurities expected under normal conditions

First Aid Measures

Inhalation: Move person to fresh air; provide oxygen if breathing is difficult; seek medical attention if symptoms persist
Skin Contact: Wash with soap and water; remove contaminated clothing; obtain medical help if irritation appears
Eye Contact: Rinse with water for several minutes; remove contact lenses if present and easy to do; seek medical attention for continued irritation
Ingestion: Rinse mouth with water; do not induce vomiting; seek medical advice if large quantity ingested or symptoms develop

Fire-Fighting Measures

Extinguishing Media: Use water spray, foam, CO2, or dry chemical extinguishers
Special Hazards: Combustion may release carbon dioxide, carbon monoxide, nitrogen oxides, or hazardous dust clouds
Protective Equipment: Firefighters must wear self-contained breathing apparatus and full protective gear
Fire-Fighting Instructions: Move containers from fire area if safe to do so; use water spray to cool containers; prevent fire-fighting runoff from entering drains

Accidental Release Measures

Personal Precautions: Evacuate unnecessary personnel; avoid breathing dust; use personal protective equipment
Environmental Precautions: Prevent entry into waterways and drains; contain spill
Clean-Up Methods: Sweep or vacuum up material avoiding creation of dust; place into suitable, labelled containers; ventilate area

Handling and Storage

Handling: Keep container tightly closed; use with adequate ventilation to minimize dust generation; handle in accordance with good industrial hygiene
Storage: Store in cool, dry, well-ventilated area; keep away from sources of ignition, moisture, and incompatible substances; avoid excessive heat
Incompatible Materials: Strong oxidizing agents

Exposure Controls and Personal Protection

Exposure Limits: No occupational exposure limit values have been established
Engineering Controls: Provide exhaust ventilation or other engineering controls to prevent airborne dust concentrations
Eye Protection: Safety glasses with side shields
Hand Protection: Protective gloves
Respiratory Protection: Dust mask or respirator in high dust conditions
Skin Protection: Suitable protective clothing
Hygiene Measures: Wash hands and face after handling; avoid eating or drinking in work area

Physical and Chemical Properties

Appearance: White to off-white, odorless powder or granules
Odor: Odorless
Odor Threshold: Not applicable
pH: 5–8 (suspension in water)
Melting Point: Not applicable (decomposes)
Boiling Point: Not applicable
Flash Point: Not available
Evaporation Rate: Not applicable
Flammability: Not flammable but can burn in fire
Vapor Pressure: Not applicable
Solubility: Insoluble in water
Partition Coefficient: Not determined
Auto-ignition Temperature: Data not available
Decomposition Temperature: Data not available
Density: Approximately 1.2–1.4 g/cm³
Viscosity: Not applicable (powder)

Stability and Reactivity

Chemical Stability: Stable under normal conditions of storage and use
Possibility of Hazardous Reactions: No dangerous reactions known under normal conditions
Conditions to Avoid: Moisture, exposure to high temperatures, open flames, and sources of ignition
Incompatible Materials: Strong oxidizers
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, under fire conditions

Toxicological Information

Likely Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Low toxicity by oral, dermal, and inhalation routes in animal studies
Skin Corrosion/Irritation: May cause mechanical irritation
Eye Damage/Irritation: Dust can irritate eyes
Respiratory Sensitization: Not expected to be sensitizing
Skin Sensitization: Not expected to cause sensitization
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Mutagenicity: No evidence of mutagenicity in available studies
Reproductive Toxicity: No evidence of reproductive toxicity in available studies
Repeated Dose Toxicity: No significant effects expected

Ecological Information

Ecotoxicity: Not expected to be hazardous to aquatic life or wildlife
Persistence and Degradability: Not readily biodegradable; polymer chemically stable in the environment
Bioaccumulation: Not expected to bioaccumulate due to insolubility and high molecular weight
Mobility in Soil: Low mobility, persistence as particulate matter
Other Adverse Effects: No known significant effects or critical hazards to the ecosystem

Disposal Considerations

Disposal Methods: Dispose according to local, regional, and national regulations; material suitable for landfill or incineration under controlled conditions
Contaminated Packaging: Remove contents completely before recycling or disposing of container; containers may be reused or recycled depending on material and local guidelines
Special Precautions: Prevent material from entering sewers, waterways, or soil during disposal
Waste Codes: Non-hazardous waste, but verify requirements with local authorities

Transport Information

UN Number: Not regulated
Proper Shipping Name: Not regulated
Transport Hazard Class: Not hazardous for transport
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant
Special Precautions for User: Avoid generating dust during handling and transport; ensure packages are secure and undamaged

Regulatory Information

TSCA Status: Listed
EU REACH: Registered
OSHA Hazard Communication: Not classified as hazardous
WHMIS (Canada): Not controlled
Japan Chemical Inventory: Listed
EINECS/ELINCS Number: 607-041-7
DSL/NDSL (Canada): Listed
Other Regulations: Ensure compliance with regional, national, and local regulations for occupational, environmental, and safety measures