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Product Name: Polysorbate 80
Synonyms: Tween 80, Polyoxyethylene (20) sorbitan monooleate
CAS Number: 9005-65-6
Recommended Use: Emulsifier in pharmaceuticals, food, cosmetics, and laboratory reagents
Supplier: Various chemical suppliers distribute Polysorbate 80 worldwide, each with a dedicated technical support team.
Contact Information: Manufacturer’s emergency phone number, available on label or product packaging
Classification: Not classified as hazardous by OSHA GHS standards under normal conditions of use
Main Hazards: May cause slight eye or skin irritation after prolonged contact. Inhalation of mists or aerosols can irritate the respiratory tract. Ingestion may cause mild gastrointestinal discomfort.
Pictograms: Not required for this product
Precautionary Statements: Use gloves and goggles in industrial settings. Provide ventilation when handling bulk quantities.
Signal word: None
Hazard statements: May be mildly irritating to sensitive individuals.
Chemical Name: Polyoxyethylene (20) sorbitan monooleate
CAS Number: 9005-65-6
EC Number: 500-019-9
Concentration: 100% (commercial-grade material is typically pure or nearly pure)
Impurities: Minor trace residues from production may be present, generally less than 1%.
Eye Contact: Flush with water for at least 15 minutes, keeping eyelids open. Remove contact lenses if present and continue rinsing.
Skin Contact: Wash skin with soap and plenty of water. Remove contaminated clothing.
Inhalation: Move to fresh air. Get medical attention if symptoms persist.
Ingestion: Rinse mouth with water. Drink water to dilute. Seek medical advice if symptoms develop.
Emergency Note: No delayed or immediate effects are expected from casual exposure; if discomfort persists, seek professional medical help.
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam.
Unsuitable Media: None known, though large amounts of water may spread spilled product.
Fire Hazards: Product may burn at very high temperatures, releasing fumes of carbon monoxide and carbon dioxide.
Protective Equipment: Wear self-contained breathing apparatus and firefighting protective clothing.
Thermal Decomposition: Combustion can produce irritating fumes and gases.
Personal Protection: Use gloves and safety goggles. Avoid skin and eye contact. Ensure adequate ventilation for bulk spills.
Environmental Precautions: Prevent large spills from entering drains or waterways.
Clean-up Method: Absorb with inert material such as dry sand or earth. Shovel into a suitable container for disposal. Wash spill site after pickup is complete.
Special Notes: Floor can become slippery; exercise care to avoid slips.
Handling: Use proper hygiene when handling. Avoid contact with eyes and prolonged skin exposure. Do not breathe vapor, mist, or spray from processing.
Storage: Store in tightly sealed original containers, away from incompatible materials such as strong oxidizers. Keep cool and dry, typically between 15–30°C. Protect from freezing.
Other Requirements: Keep out of reach of children and untrained personnel. Store in well-ventilated areas.
Exposure Limits: No established occupational exposure limits for Polysorbate 80.
Engineering Controls: Use local exhaust for extensive handling.
Personal Protection: Wear protective gloves, safety glasses or goggles. Aprons or lab coats recommended in industrial settings.
Respiratory Protection: Not usually required; use NIOSH-approved respirator if product forms mist above normal handling level.
Hygiene Measures: Wash hands thoroughly after handling. Do not eat or drink while handling the product.
Form: Oily liquid
Color: Pale yellow to amber
Odor: Slight, characteristic odor
pH: Approximately 6–8 for a 5% solution
Boiling Point: >100°C (212°F)
Melting Point: 0°C to 5°C (32°F–41°F)
Flash Point: >149°C (>300°F) (Closed cup)
Solubility: Soluble in water, alcohol, and most organic solvents
Density: 1.06 g/cm³
Viscosity: 300–500 cP at 25°C
Partition coefficient (log Kow): Low
Chemical Stability: Stable under recommended storage and handling conditions.
Reactivity: Not reactive with most materials under normal conditions.
Conditions to Avoid: Excessive heat, sources of ignition
Incompatible Materials: Strong oxidizing agents can degrade the product.
Hazardous Decomposition: Combustion releases carbon monoxide, carbon dioxide, traces of other organics.
Polymerization: Will not occur.
Acute Toxicity: Low acute toxicity by oral, dermal, and inhalation routes. LD50 (oral, rat) > 25,000 mg/kg.
Irritant Effects: Can cause mild eye and skin irritation on repeated exposure.
Sensitization: Not a known skin sensitizer in most individuals.
Long-term Exposure: Chronic toxicity studies show no evidence of carcinogenicity or reproductive effects at typical exposure levels.
Other Effects: Large quantities may lead to digestive discomfort if ingested.
Toxicity: Low toxicity to aquatic life; LC50 (fish, 96h): >100 mg/L.
Persistence and Degradability: Readily biodegradable by environmental bacteria.
Bioaccumulation Potential: Low potential given low log Kow and high solubility.
Mobility in Soil: Product is mobile in the environment and will partition into water.
Other Effects: No persistent, bioaccumulative, or toxic characteristics identified by REACH or GHS.
Waste Treatment: Dispose in accordance with local, regional, and national regulations. Most areas allow for disposal as non-hazardous chemical waste.
Container Disposal: Triple rinse containers, offer for recycling or dispose of in an approved landfill.
Special Precautions: Avoid release to natural waterways.
Methods: Incineration or landfill, following all local authority regulations.
UN Number: Not regulated as dangerous goods per DOT, IATA, IMDG, or ADR rules.
Proper Shipping Name: Polysorbate 80
Transport Hazard Class: Not classified
Packing Group: Not applicable
Environmental Hazards: None identified
Special Precautions for User: No special transport requirements. Keep containers sealed and upright.
OSHA Hazard Communication: Not a hazardous material under 29 CFR 1910.1200.
US TSCA: Listed
REACH Registration: Listed and registered
Canada DSL: Listed
California Prop 65: Not listed
FDA Status: Allowed as a food additive and excipient in specified uses
Other International Listings: Registered or permitted in major global regulatory inventories
Labeling: No hazard pictograms or precautionary labeling required
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
