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Material Safety Data Sheet – Polysorbate 20

Identification

Product Name: Polysorbate 20
Chemical Family: Nonionic surfactant
Common Synonyms: Polyoxyethylene (20) sorbitan monolaurate, Tween 20
CAS Number: 9005-64-5
Recommended Use: Emulsifier, dispersing agent, solubilizer in food, cosmetic, and pharmaceutical products
Supplier Information: Information available from product distributor or manufacturer
Contact for emergency: Refer to manufacturer’s 24-hour emergency helpline

Hazard Identification

Classification: Not classified as hazardous under GHS
Primary Hazards: Eye and skin irritation may occur with direct contact. Large amounts might upset the stomach if ingested.
Precautionary Statements: Avoid direct contact with eyes and prolonged skin contact. Keep away from incompatible substances.
Pictograms: Not classified as requiring pictograms under GHS
Signal Word: None
Hazard Statements: May cause mild irritation to eyes.
Other Hazards: Spills may cause a slippery surface.

Composition / Information on Ingredients

Chemical Name: Polyoxyethylene (20) sorbitan monolaurate
CAS No.: 9005-64-5
Content: Typically >99% by weight
Impurities: Minor components resulting from manufacturing may be present at <1%
Additives: No preservatives or additives reported in standard formulations

First Aid Measures

Eye Contact: Rinse immediately with water for several minutes, keeping eyelids open. Remove contact lenses if present and easy to do. Seek medical attention if discomfort persists.
Skin Contact: Wash exposed skin thoroughly with soap and water. Remove contaminated clothing. If irritation develops, consult a doctor.
Inhalation: Remove to fresh air. Most forms are liquid and do not present inhalation risk unless heated or aerosolized.
Ingestion: Rinse mouth with water. Drink plenty of water. Call a doctor if large amounts are ingested or if symptoms develop.

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, foam, dry powder, carbon dioxide (CO2)
Unsuitable Media: Direct water jet may spread product.
Hazards: In combustion, may emit carbon oxides and other unknown toxic fumes.
Protective Equipment for Firefighters: Full protective clothing and self-contained breathing apparatus.
Special Precautions: cool containers with water spray to prevent pressure build-up in case of fire.

Accidental Release Measures

Personal Precautions: Avoid direct contact with the material. Use protective gloves, goggles, and suitable footwear to prevent skin and eye contact.
Environmental Precautions: Prevent from entering drains, waterways, or soil.
Containment Methods: Stop leak at source if safe. Use absorbent materials like sand, earth, or vermiculite.
Cleanup Methods: Collect spilled material and place in suitable waste containers for proper disposal. Wash spill site with water after material pickup is complete.

Handling and Storage

Handling: Use in well-ventilated areas. Wear suitable gloves and eye protection. Avoid forming aerosols or splashing.
Storage Conditions: Store at room temperature, away from sunlight, moisture, and oxidizing agents. Keep containers closed when not in use.
Incompatible Materials: Strong acids, strong bases, strong oxidizers.
Packaging: Use original, corrosion-proof containers with secure lids.

Exposure Controls and Personal Protection

Engineering Controls: General ventilation is generally adequate.
Personal Protection: Wear protective gloves, chemical-resistant eyewear, and, if splashes are likely, chemical-resistant apron.
Respiratory Protection: Not required under normal, ambient conditions. If aerosolized, use NIOSH-approved respirator.
Hand Protection: Nitrile or neoprene gloves recommended.
Eye Protection: Safety goggles or face shield.
Hygiene Measures: Wash hands thoroughly after handling. Do not eat, drink, or smoke during use.

Physical and Chemical Properties

Appearance: Amber to pale yellow liquid
Odor: Mild, characteristic
Odor Threshold: No data
pH: 5.0 – 7.0 (1% aqueous solution)
Melting Point/Freezing Point: -5°C
Boiling Point: >100°C
Flash Point: >149°C (closed cup)
Evaporation Rate: Negligible
Flammability: Not classified as flammable
Vapor Pressure: <0.1 mm Hg @ 20°C
Vapor Density: No data
Relative Density: 1.05 – 1.10 @ 25°C
Solubility: Soluble in water
Partition Coefficient: Log Pow <1
Auto-Ignition Temperature: >300°C
Decomposition Temperature: >200°C
Viscosity: 350 – 450 cP @ 25°C
Molecular Weight: Average 1226 g/mol (varies with degree of ethoxylation)

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions.
Reactivity: No dangerous reactions under normal use.
Possibility of Hazardous Reactions: Reacts with strong oxidizing agents.
Incompatible Materials: Strong acids, strong bases, and strong oxidizing agents.
Hazardous Decomposition Products: Carbon oxides (CO, CO2), possible traces of acrolein when overheated.
Conditions to Avoid: Excessive heat, exposure to light for prolonged periods.

Toxicological Information

Acute Toxicity: Oral LD50 (rat) estimated >25,000 mg/kg; low toxicity.
Skin Corrosion/Irritation: Mild, transient skin irritation possible after prolonged exposure.
Serious Eye Damage/Irritation: Mild, transient eye irritation if splashed.
Respiratory Sensitization: No expected risk under normal use.
Skin Sensitization: Not considered a sensitizer in most individuals.
Chronic Toxicity: Not classified as carcinogenic, mutagenic, or toxic to reproduction.
Potential Health Effects: High exposure may cause gastrointestinal upset.
Medical Conditions Aggravated: Pre-existing skin disorders may worsen with repeated and prolonged contact.

Ecological Information

Ecotoxicity: Low aquatic toxicity. LC50 (fish, 96h): >100 mg/L; EC50 (Daphnia, 48h): >100 mg/L.
Persistence and Degradability: Readily biodegradable in environmental conditions.
Bioaccumulative Potential: Low potential for bioaccumulation (log Pow <1).
Mobility in Soil: High mobility due to solubility in water.
Other Adverse Effects: No evidence of significant environmental hazard when used responsibly.

Disposal Considerations

Waste Treatment Methods: Dispose of contents/container in accordance with local, regional, and national regulations.
Recommended Disposal: Absorb spillage with inert material and collect for disposal. Do not dump into sewers or watercourses.
Contaminated Packaging: Rinse containers thoroughly then recycle or dispose through approved facility.
Disposal Regulation Codes: Consult local and regional authorities for waste classification.

Transport Information

UN Number: Not regulated
UN Proper Shipping Name: Not applicable
Transport Hazard Class(es): Not hazardous
Packing Group: Not assigned
Environmental Hazards: None known
Special Precautions: Protect containers from physical damage.
Transport Regulations: Compliant with ADR, IMDG, IATA, RID

Regulatory Information

US Regulation (OSHA): Not subject to OSHA hazardous chemical regulations.
EPA TSCA Status: Listed on TSCA inventory.
EU Regulation (REACH): Listed as a registered substance. Not classified as hazardous.
Canadian DSL Status: Included on DSL.
Other National Inventories: Present on AICS (Australia), ENCS (Japan), ECL (Korea), PICCS (Philippines), IECSC (China).
SARA Sections 302/304/313: Not listed.
Hazard Symbols: None required.
Labeling Requirements: No GHS hazard signal required.
Other Information: Product subject to food and cosmetic regulations when used in those applications.