Polyethylene oxide’s timeline stretches back to the mid-20th century, just as the world realized polymers turn possibilities into real progress. For decades, labs chased ways to create new materials that push the limits of what could be dissolved, thickened, or stabilized. Polyethylene oxide, sometimes just called PEO, came into focus as chemists tinkered with ethylene oxide, working up ways to link its simple units into long, flexible chains. Over time, it turned out that tweaking the molecular weight—how long those chains grow—makes the same material behave like two different beasts, swinging between a viscous liquid and a tough, waxy solid with a subtle hand. Companies like Union Carbide once drove early market adoption of PEO, and they didn’t just do it for fun—the stuff got picked up for real-world problems, like improving paints, pharmaceuticals, and even oil recovery. As I look at old patent files, I notice how early researchers were fascinated by the new softness and “slipperiness” this polymer brought. Today’s applications stand on their shoulders, but the odd excitement of those first few decades still shows up in labs that try to make things work smoother or stretch further for patients, engineers, and environmental scientists.
Polyethylene oxide typically comes as a white, powdery solid, sometimes molded into pellets or granules. Depending on how long the polymer chains reach, it can look and handle more like sugar or lean closer to a wax. These materials dissolve easily in cold or warm water, sometimes leaving behind the barest shimmer of a solution thick enough to hold suspended solids. The broad range of available molecular weights, from below 100,000 to upwards of five million, gives both engineers and formulators the flexibility to tune the solution’s thickness from runny to almost gel-like. In industrial settings, brands use trade names such as Polyox (DuPont), Macrogol (pharmaceutical), and Polyviscol, each carrying subtle tweaks in chain length, residue profile, or purity, based on the market demand. One thing that stands out for those working with this material—the reliability. Bags of powder coming off the shelf stay remarkably consistent in how they behave and mix, a relief in a field where batch-to-batch variation leads to endless headaches.
This polymer shows off a few quirks that set it apart. Its high solubility in water, unusual among high-molecular-weight polymers, lets it thicken fluids or act as a lubricant without gumming up the works. Chemically, PEO chains carry repeating units of ethylene oxide, (-CH2-CH2-O-), that link up in a way that doesn’t break down easily under normal environmental conditions. In the lab, PEO won’t catch fire easily, and it does not readily react with mild acids or most salts. These qualities aren’t accidental—developers learned through trial and error just how durable a water-soluble chain could be before it falls apart under stress. Viscosity changes dramatically with chain length, swinging from a pourable solution to a sticky gel with just a small jump in molecular size. It melts gradually, usually around 65-70°C, well below typical plastics, which allows for safe processing in pharmaceutical or food settings. This melting point, lower than polyethylene glycol, means it fits nicely into applications where gentle heat, not brute force, does the job.
In my experience, getting a grip on technical details means diving into certificates of analysis and sifting for numbers like molecular weight, polydispersity index, residual solvent level, ash content, and moisture percentage. Most vendors rate the molecular weight precisely, because the whole application—be it tablet lubricant or industrial flocculant—hinges on this figure. Viscosity ratings also dominate, expressed in centipoise at set concentrations, so the same “grade” behaves the same way in every tank or reactor. Packaging and labeling typically cover not only identification and manufacturing batch but also regulatory compliance, such as European Pharmacopoeia (Ph. Eur.), United States Pharmacopeia (USP), or FDA status. Food- and drug-grade PEO announces its production lineage proudly, since one batch error can ripple out to thousands of doses or tons of finished goods. Suppliers often highlight the maximum residue levels of heavy metals and microbial content, making life easier for quality assurance teams who face strict inspection and compliance deadlines.
The backbone of PEO production sits in the polymerization of ethylene oxide gas, usually in organic solvent or aqueous media, under pressure and at a moderate temperature. Catalysts like potassium or sodium hydroxide push the ethylene oxide monomers to chain together, with process tweaks steering the reaction toward either shorter or much longer chains. Careful regulation of temperature, pressure, catalyst concentration, and time controls the average molecular weight and narrows the distribution—critical for batch-to-batch consistency. Sometimes, manufacturers add co-monomers or modify the environment to build in custom functionality or ensure the product's final purity. Washing and drying steps follow, stripping away catalyst residues and leftover monomers before powder or pellets reach the market. Drawing a well-made batch isn’t just about chemistry; there’s an art to dialing in the reactor conditions, keeping occasional runaway exotherms or side reactions at bay, and making sure the end product doesn’t carry unexpected color or odor.
Polyethylene oxide reacts at its chain ends, enabling chemists to attach other molecules, change solubility, or allow crosslinking for even more demanding roles. Chemical modification targets the terminal hydroxyl groups, which means surfactants, drugs, or other polymers can be grafted on to create emulsifiers, hydrogels, or drug conjugates. Oxidation, esterification, and etherification steps represent the standard toolbox for these changes. In some labs, adding ionic groups to side positions converts PEO into a polyelectrolyte for water treatment. More recently, creative work hinges on “click chemistry” approaches, where azide or alkyne groups get added for ultra-precise coupling with other molecules—allowing delivery of chemotherapy agents, imaging dyes, or anti-inflammatory drugs. A lot of the deep innovation comes from medical or nanotech teams, borrowing approaches straight from organic chemists who see every coupling as a puzzle with a patient or a new device on the other end.
Step into any chemical storeroom, and you might hear it called Polyox, Macrogol, Polyethylene glycol oxide, or even just “high MW PEG.” The terms differ with industry and application, sometimes even by regulatory label. Macrogol shows up most often on drug ingredient labels, as in stool softeners or as a carrier for pills. Polyox claims its spot in industrial applications, snapping up roles in adhesives, coatings, and water treatment, often bearing a grade number that points straight to its average molecular weight. Long technical names for polyethylene oxide rarely escape the confines of regulatory filing or import/export documents, where precision trumps day-to-day chat. It makes sense, since the same chain drapes across everything from medical devices to glue sticks, so tracking the chain length and any additives helps cut confusion between fields as different as pharmacy and mining.
Working with PEO requires a sensible approach to both dust and potential contact. The polymer itself isn’t classified as a hazardous substance under most international labeling rules, but fine powder can become airborne, so operators stick to face masks or dust collection to protect lungs. Inhalation of massive doses triggers only low-level respiratory irritation in animal studies, and the material doesn’t stir up allergies or severe skin sensitivity in most staff. Combustion releases carbon monoxide and carbon dioxide, nothing particularly exotic—so standard fire extinguishers do the job. Facilities keep spill kits and wash stations close by out of prudence, especially since floors can get slick when mixed with water. In regulated settings like drug plants, extra care goes into raw material tracing and cross-contamination checks, with robust cleaning between processing cycles. The FDA and the European Medicines Agency both enforce strict oversight, especially for pharmaceutical grade PEO. As someone who’s run a few pilot-scale operations, I’ve learned that keeping humidity controlled and storerooms dry prevents agglomeration and caking—the worst enemies of reproducible dosing and mixing.
Polyethylene oxide steps onto a big stage in medicine, agriculture, and industry. In pharmaceuticals, it acts as a tablet binder, laxative (macrogol), and even as a controlled delivery matrix for long-acting drugs. Drug delivery teams like its compatibility, since it lets hydrophobic or sensitive molecules slip through the digestive system with less breakdown. Paint makers rely on PEO for its ability to modify viscosity and stability, especially for waterborne coatings where low odor and consistent brushing matter. In water treatment, the same chains grab tiny particles and help them settle out, cutting turbidity and clarifying drinking or wastewater. The agriculture sector uses it for soil conditioning, helping water spread more evenly into hard-packed ground, and some specialty food and cosmetic blends use lower-molecular-weight PEO as a thickening or stabilizing ingredient. Even oil and gas teams know that pumping fluids with PEO smooths out flow and reduces friction in pipelines—a neat trick that saves a small fortune on pumping energy. Every year, it seems a new application finds a home for this versatile polymer, thanks in large part to its chemical reliability and low toxicity.
Current research keeps spinning up new ways to exploit PEO’s properties. Materials scientists continue to explore how chain branching, controlled-end functionalizations, and hybrid blends create new films or fibers for next-generation batteries and medical devices. Electrolyte research grabs headlines, since incorporating lithium salts into PEO matrices enables flexible batteries and solid-state supercapacitors—markets that hunger for any edge in performance or safety. Drug formulation teams dive into the nano-scale possibilities, entraining chemotherapy agents or vaccine molecules inside PEO-based micelles to improve distribution and reduce side effects. Environmental researchers see promise in modified PEO for picking up metals, pesticides, or even PFAS contaminants. Each laboratory breakthrough brings small adjustments, but over time, the toolbox expands as we understand not just what PEO can do today, but what twists and combinations will solve tomorrow’s unsolved problems. Collaborations between physicists and chemists matter here—something I’ve witnessed directly, as rare meetings of minds can leapfrog a field forward just by cross-pollinating new ideas.
Studies across the pharmaceutical and chemical industries suggest that polyethylene oxide ranks among the safest water-soluble polymers for both short- and long-term exposure. Oral and dermal toxicity studies in rats and dogs, often conducted under the high standards required for drug approval, point to extremely low absorption of high-molecular-weight chains, which helps avoid accumulation in organs. Lower-molecular-weight grades, like those near polyethylene glycol, pass through the human system rapidly. Regulatory agencies such as the FDA and EFSA review these findings and generally treat macrogol derivatives as “generally recognized as safe” (GRAS) in food and medicine up to established limits. Allergenicity and skin sensitization track at nearly background levels, provided no impure additives sneak in during production. Ongoing studies keep focus on chronic exposure at high doses and rare scenarios where PEO fragments could cross biological barriers or disrupt groundwater flows, but so far, reviews keep supporting the safety profile that let this polymer spread so widely in medicine and consumer goods.
The next decade for polyethylene oxide looks full of promise. In energy, PEO-based solid electrolytes are gearing up to change how flexible electronics and safer batteries operate. Medicine pushes ever deeper into targeted delivery, where sophisticated drug-polymer conjugates ride on the polymer’s proven track record to solve hard delivery problems—getting cancer drugs deep into a tumor or ferrying gene-editing machinery into cells without toxic byproducts. Environmental work raises hope that modified PEO chains will help remove trace pollutants from water and soil, fitting into a broader trend toward sustainable materials that recycle cleanly or degrade safely. I expect real progress from efforts to squeeze new functions out of copolymer blends, crosslinked gels, and surface modifications that let PEO stick or release on command. As regulations get stricter and new markets demand lower toxicity and higher performance, researchers and manufacturers will keep raising the bar, looking for smart ways to tune a well-understood material for tomorrow’s toughest jobs.
Polyethylene oxide, often known by its acronym PEO, rarely grabs headlines, but it quietly shapes a lot of the products people rely on. My first real encounter with PEO came at a college internship at a drug formulation lab. Watching pharmacists bring together powders and liquids, it hit me just how many different industries depend on this one material. Its strength lies in its ability to dissolve in water, thicken liquids, and bind powders together. Anybody who has opened a packet of instant drink or uses generic over-the-counter tablets has likely bumped into PEO's handiwork, even if they didn’t realize it.
One of PEO’s main jobs shows up at the pharmacy. Tablet and capsule makers turn to PEO when they want a pill to hold its shape and dissolve at just the right rate inside the body. It binds drugs and fillers together, letting medicine keep a consistent shape through shipping and storage. PEO also helps control how fast the medicine is released in your system, so that a fever reducer, for example, doesn’t flood the body all at once. The FDA’s guidelines for sustained-release drug formulations list PEO as a preferred polymer, because it offers both safety and predictability. This level of reliability in a medication’s action especially helps patients with chronic conditions who count on their doses lasting over many hours.
Take a look at toothpaste or shampoo. The smooth texture and easy squeeze from the tube owe a debt to PEO. In lotions, creams, and gels, PEO makes sure these personal care staples go on evenly, don’t separate, and stay just thick enough to feel nice on skin. PEO is even safe enough for sensitive uses, earning favor with manufacturers looking to reduce irritation in products made for regular use. Skin health experts recommend ingredients like PEO for their balance of gentleness and function, helping folks with allergies use fewer products that cause reactions.
Factories have been making use of PEO for decades. Paper mills add it to pulps for stronger, more flexible paper. Textile plants count on PEO to help dye stick to fibers evenly. My uncle ran a small wastewater facility, and I remember him explaining how the polymers could pull out dirt from water, making it safer to send downriver. The Environmental Protection Agency actually lists polymers like PEO as helpful agents in flocculation, where particles clump together so filters can catch them. What strikes me is how a polymer in a shampoo bottle at home can also help clean up after big manufacturing processes.
Hospitals and surgeons rely on PEO-based gels for wound care and drug delivery patches. Researchers looking for better ways to deliver cancer drugs have turned to PEO since it can help medicines travel through the body longer. Companies are developing dissolvable bandages and slow-release patches that use PEO, allowing for more precise treatments without repeat doctor visits.
Cost and environmental persistence remain the biggest challenges. PEO does wonders, but scientists are working to improve its breakdown after use, addressing concerns about plastics in the environment. University researchers in Europe are testing bio-based versions to reduce the reliance on petroleum. Overcoming these hurdles will shape how much further PEO spreads beyond the pharmacy and factory.
Polyethylene oxide (PEO) often gets tucked away in long ingredient lists on food labels or pharmaceutical inserts, but its presence has sparked debates among scientists and everyday shoppers. The stuff looks plain—just a white powder with a slippery feel. In labs, it’s widely used in everything from laxatives to the coatings on pills. Folks who work in pharmacies or food manufacturing might recognize the name because it’s relied on for how well it dissolves and mixes, making medicines easier to take, or keeping food texture smooth.
Regulatory agencies have taken plenty of looks at this ingredient. The US Food and Drug Administration (FDA) gives a nod to polyethylene oxide for specific uses in pharmaceuticals. They’ve granted it a “Generally Recognized As Safe” (GRAS) status for food, but only in small amounts. European health agencies set similar rules. Having worked in a health products store, I saw customers who relied on PEO-based laxatives for years, never reporting bad side effects—though they always stressed the importance of following dosing instructions.
Most governments ask that manufacturers stay within strict quantity limits. The science behind these guidelines rests on studies where animals got megadoses compared to what a person would see in real life. The studies end up showing PEO passes through the system mostly unchanged and doesn’t break down into harmful substances along the way.
Trouble creeps in when people misuse household or industrial chemicals. Not all PEO is created equal; industrial versions may come with remnants of toxic chemicals from the manufacturing process, so using those in food or medicine would be a big mistake. Only pharmaceutical- or food-grade PEO—made under safer conditions—belongs in anything people eat or swallow. Anyone who has mixed up their own food recipes using thickeners will know there’s a big difference between what’s safe in a kitchen and what’s safe in a plastics plant.
Scandals do pop up now and then, though rarely with polyethylene oxide. Sometimes, companies cut corners and slip unapproved additives into products or get sloppy with cleanliness in factories. Good manufacturing practices (GMP) should push companies to test every batch and track every ingredient, from supplier to supermarket shelf. Shoppers and patients shouldn’t assume every product is safe just because it winds up on a shelf; ask questions and look up trusted brands.
From a nutrition perspective, nobody needs extra polyethylene oxide in their diet. The only folks who benefit directly are those who struggle with constipation or who can’t take pills easily—PEO makes these products easier on the body. Long-term, most studies find no evidence of buildup or toxic reactions, but it pays to stay updated. Consumer watchdogs and professional associations keep tabs on new findings, alerting the public if something changes.
Problems often come from mixing ingredients at home or trusting internet recipes that claim you can use PEO without proper training or food-grade supplies. I’ve seen community forums full of confusion about what’s safe to use. Education helps bridge the gap: science teachers, pharmacists, and even online health creators carry responsibility by repeating which versions of an ingredient are safe and why.
There’s a real need for clearer labeling, so buyers can see at a glance whether a product uses pharmaceutical-grade or food-grade PEO. Companies could invest in public safety campaigns or simple icons on packaging. Health agencies should stick to strict inspections and keep databases available for public review: anyone who wants to dig deeper shouldn’t hit a paywall.
Until new research proves otherwise, polyethylene oxide in approved amounts and purity levels stands as safe. As with every ingredient, knowledge, oversight, and honest communication protect public trust.
Walk into a chemicals store or flip through a polymer supplier’s catalog, and you’ll spot Polyethylene Oxide, usually abbreviated as PEO. The stuff looks unremarkable, sometimes a powder, sometimes pellets. Lab people and industrial operators care less about what it looks like and more about the numbers surrounding it. These numbers, its molecular weight, spell out exactly how PEO behaves—from pharmaceutical pills to sludge-thickening and even the slick stuff coating disposable razors.
Let’s drop the jargon. Molecular weight tells you how long the “train” of molecules is. Small chains mean the stuff pours like table salt and dissolves quickly. Big chains make it stretchy, hard to dissolve, and turn water gloopy.
PEO comes in wildly different lengths. Suppliers commonly offer grades ranging from about 100,000 all the way up to 8,000,000 grams per mole (g/mol). Lower weights, around 100,000 to 600,000, flow and dissolve quickly. User groups dealing with coatings or simple lubricants usually work in this zone.
Jump past 1,000,000 g/mol and PEO starts to behave more like a magic thickener. At 4,000,000 and up, it transforms water into gel—think sludge for mining or the kind of gel used in drug delivery systems. In high-tech labs, ultra-high PEO, around 7,000,000 to 8,000,000 g/mol, gets tested as a drag-reducing agent. Researchers love this stuff because even tiny amounts flip the script on how fluids flow through pipes.
My experience in water treatment once forced me to trial half a dozen PEO grades before anything met the plant’s strict specifications. We discovered that the higher molecular weights, especially above 2 million, offered the punch needed to bind fine particles. Switching to a lower grade actually failed to produce the required flock, wasting both material and water.
It’s tempting to grab the highest molecular weight, thinking more means better. In practice, high molecular PEO sometimes refuses to dissolve, especially in cold water. Skipping proper mixing produces annoying lumps that plug filters or pipes.
Fact: a mid-weight PEO, somewhere between 600,000 and 2,000,000 g/mol, finds the most use in everyday product formulations. Medical tablet makers, for example, choose these grades for their balance of solubility and gelling power—without making things impossible to process.
Buyers should never guess; they need specs. Data sheets often list “viscosity,” which hints at the actual molecular weight. My stint in pharmaceutical development hammered this home. Picking an unsuitable PEO meant erratic release times for drugs, risking patient safety and flushing research hours down the drain.
Some suppliers now publish not only molecular weight, but also info on polydispersity, the distribution of those chain lengths. Narrower distributions give greater predictability in industrial batches. Eco-minded groups push for PEO grades that biodegrade faster, and research into greener synthesis methods picks up pace.
Anyone using PEO today needs good records, steady partners, and a willingness to call out suppliers to explain the fine print. The story of this polymer isn’t just in the chemistry, but in every headache and breakthrough along the supply chain.
Polyethylene oxide, known across labs and factories for its unique properties, calls for careful attention in the storeroom. People use it everywhere—from making medicine tablets stick together, to thickening shampoos. The way workers treat this powder day-to-day determines not only the product’s quality but also their own safety.
Humidity causes real trouble for polyethylene oxide. It has this knack for absorbing water right out of the air. I’ve seen bags go from a free-flowing powder to a gummy mess after just a few hours left open in a humid room. To sidestep this headache, store it in airtight containers. Polyethylene oxide lasts much longer and stays workable in original packaging or sealed drums. Rooms with climate control or at least low moisture give extra peace of mind.
Sunlight and heat also bully this polymer. On hot days, a warehouse without steady temperature control can speed up the breakdown of polyethylene oxide. Stash the material away from windows or direct sources of warmth. Many manufacturers put clear storage temperature guidelines on their packaging, most asking for a spot under 30 degrees Celsius. Keeping it cool and dark protects both effectiveness and shelf life.
Open containers and dusty bags pose a risk in any shared workspace. I once watched a batch go bad because the scoop used for polyethylene oxide also got dipped in sodium chloride. Mixing supply tools across powders throws off quality. Use dedicated scoops, clear labeling, and keep unrelated chemicals elsewhere. Fresh gloves and clean work surfaces always help keep things tidy and safe.
Polyethylene oxide’s fine particles become airborne with little disturbance. Breathing this dust over a shift leads to irritation, especially for folks with asthma. Respiratory worries go up a notch when you’re cleaning up spills. Dust masks or respirators, safety glasses, and gloves take pressure off workers’ health. Handling this polymer in spaces with good extraction—or at the very least, plenty of ventilation—makes a noticeable difference. If someone spills the powder, wet down the area to keep dust low and sweep it up with care.
It won’t burst into flames easily, but fine polyethylene oxide dust belongs nowhere near open sparks. Thick clouds of dust, if given a lighting source, can flash up fast. Clean up spills right away and don’t let dust build up in corners or on warehouse beams. Most companies build up their own training programs to reduce the risk, including fire drills focusing on powder spills.
Proper storage and handling lessen both accidents and costly write-offs. Written logs, batch numbers, and inventory checks help track what comes in and out—plus who’s accountable. Training new staff with hands-on demonstrations cuts down on mix-ups. Relying on routine habits and making safety part of the daily workflow means fewer surprises.
Storing and handling polyethylene oxide isn’t glamorous, but it shapes the bottom line for a business. Workers count on clear labels, dry bins, and good air circulation. A little care up front means the powder gets used up before it absorbs water, loses strength, or ends up as a sticky hazard in the storeroom. Dry, clean, and cool—these old rules still pay off. The right setup protects both the people on the floor and the quality that keeps customers coming back.
Polyethylene Oxide (PEO) has always struck me as one of those materials that quietly pops up in places people don’t expect. In my experience working alongside pharmaceutical mixers and textile engineers, you’ll hear about PEO most often because it plays well with water. Drop the powder or beads into a beaker, stir for a bit, and you’ll see how it dissolves to form a thick, gooey solution. This high solubility comes from the repeated ether linkages in PEO’s backbone, making it hydrophilic. There’s no fuss over temperature either—cold or warm, PEO usually mixes in, as long as the molecular weight’s not sky-high. Once the molecular weight climbs into the millions, patience and a vigorous stir become necessary, but you still end up with a solution.
Lab techs and plant workers know this matters. If it didn’t dissolve so well, industry folks couldn’t use it for things like tablet coating, thickening bath solutions, or even water-based personal care products. PEO’s water solubility flows naturally into those uses.
People sometimes assume if a polymer loves water, it’ll work for everything else. That doesn’t track with Polyethylene Oxide. You toss PEO in ethanol or acetone and it turns stubborn, refusing to dissolve. It gels or lumps, proving that it only “likes” solvents with similar hydrogen bond profiles. PEO’s compatibility lines up with strongly polar ones—formamide, for example—but not with low polarity alcohols or simple hydrocarbons.
I remember an instance in a university lab, watching students try to mix PEO into methanol. No matter what they did, all they got was a lumpy mess. That sort of trial teaches how PEO doesn’t always act like classic water-loving polymers such as polyvinyl alcohol, which can sometimes manage limited solubility in alcohols. PEO keeps its range tight.
This trait defines PEO’s role in everyday products. The medical field leans on it for its ability to blend quickly and create clear solutions. In agriculture, mixing PEO with pesticide solutions works because it swells and sustains viscosity in water-heavy mixtures. The textile industry counts on it for sizing agents that dissolve and wash out cleanly. By being picky about solvents, PEO limits cross-contamination in these processes and helps maintain predictable product quality.
Solubility also controls waste disposal and reuse options. With almost no solubility in non-polar solvents, PEO doesn’t spread where it shouldn’t—so textile wash water, for example, isn’t ruined if a bit of oil-based solvent gets thrown in the mix.
Some environmental advocates have flagged concerns about water-soluble plastics polluting streams. Here, industry and academia have developed better wastewater filtering, as well as using more recyclable or biodegradable PEO grades. Water treatment plants now optimize filtration systems to grab PEO before it reenters bodies of water.
Getting more out of PEO hinges on blending it with other polymers or tweaking the chemistry so it works in broader solvent systems. Research into “graft copolymers” and new PEO derivatives sparks hope for mixing with organic solvents, but scaling that up takes time. Meanwhile, technical support staff on the ground are developing better mixing methods for those monster molecular weights, cutting down on undissolved clumps.
All told, Polyethylene Oxide’s straightforward relationship with water anchors its importance, but the real progress happens through careful handling, practical know-how, and new research to bridge those solubility gaps in other solvents. That blend of hands-on skill and scientific exploration hints at smart, sustainable solutions ahead.
| Names | |
| Preferred IUPAC name | poly(oxyethylene) |
| Other names |
Polyox Polyethylene glycol oxide PEO Poly(ethylene oxide) Poly(oxyethylene) Polyethylene oxide homopolymer |
| Pronunciation | /ˌpɒl.iˈɛθ.ɪˌliːn ˈɒk.saɪd/ |
| Preferred IUPAC name | poly(oxyethylene) |
| Other names |
Polyox Poly(ethylene oxide) PEO Polyethylene glycol (high MW) Polyethyleneglycolum Poly(oxyethylene) |
| Pronunciation | /ˌpɒl.iˈɛθ.ɪˌliːn ˈɒk.saɪd/ |
| Identifiers | |
| CAS Number | 25322-68-3 |
| Beilstein Reference | 1307540 |
| ChEBI | CHEBI:28216 |
| ChEMBL | CHEMBL1277861 |
| ChemSpider | 21106421 |
| DrugBank | DB09221 |
| ECHA InfoCard | ECHA InfoCard: 100.022.169 |
| EC Number | 600-374-5 |
| Gmelin Reference | 8558 |
| KEGG | C19583 |
| MeSH | D010927 |
| PubChem CID | 24849 |
| RTECS number | MD1270000 |
| UNII | C3H9504Y1X |
| UN number | UN3082 |
| CompTox Dashboard (EPA) | DTXSID7020246 |
| CAS Number | 25322-68-3 |
| Beilstein Reference | 1312994 |
| ChEBI | CHEBI:8016 |
| ChEMBL | CHEMBL54274 |
| ChemSpider | 26710 |
| DrugBank | DB09531 |
| ECHA InfoCard | ECHA InfoCard string for Polyethylene Oxide: 100.011.148 |
| EC Number | 200-995-9 |
| Gmelin Reference | 1001156 |
| KEGG | C02598 |
| MeSH | D010927 |
| PubChem CID | 24856 |
| RTECS number | MD2540000 |
| UNII | C2R9C7ZNE6 |
| UN number | UN3082 |
| Properties | |
| Chemical formula | (C2H4O)n |
| Molar mass | (44.05 g/mol)ₙ |
| Appearance | White powder or granules |
| Odor | Odorless |
| Density | 1.2 g/cm³ |
| Solubility in water | Soluble in water |
| log P | “1.54” |
| Vapor pressure | Negligible |
| Acidity (pKa) | ~15.0 |
| Magnetic susceptibility (χ) | −9.0 × 10⁻⁶ (SI units) |
| Refractive index (nD) | 1.455 |
| Viscosity | High |
| Dipole moment | 1.99 D |
| Chemical formula | (C2H4O)n |
| Molar mass | (44.05 g/mol)n |
| Appearance | White powder or granules |
| Odor | Odorless |
| Density | 1.2 g/cm³ |
| Solubility in water | soluble |
| log P | 1.54 |
| Vapor pressure | Negligible |
| Acidity (pKa) | ~15.0 |
| Basicity (pKb) | 4.5 |
| Magnetic susceptibility (χ) | −9.0×10⁻⁶ |
| Refractive index (nD) | 1.456 |
| Viscosity | 1,100–8,800 cP |
| Dipole moment | 1.88 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 229.0 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -462.0 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -2886 kJ/mol |
| Std molar entropy (S⦵298) | 216.0 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -462.6 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -2700 kJ/mol |
| Pharmacology | |
| ATC code | A06AD15 |
| ATC code | A06AX04 |
| Hazards | |
| Main hazards | May cause eye, skin, and respiratory tract irritation |
| GHS labelling | No GHS labelling. |
| Pictograms | GHS07 |
| Signal word | Warning |
| Precautionary statements | P264, P270, P301+P312, P330, P501 |
| NFPA 704 (fire diamond) | NFPA 704: 1-1-0 |
| Autoignition temperature | 350°C |
| Lethal dose or concentration | LD50 Oral Rat > 2,000 mg/kg |
| LD50 (median dose) | LD50 (median dose): >2,000 mg/kg (rat, oral) |
| NIOSH | QA3225000 |
| PEL (Permissible) | PEL not established |
| REL (Recommended) | REL (Recommended Exposure Limit): Not established |
| Main hazards | May form explosive dust-air mixtures. |
| GHS labelling | Non-hazardous according to GHS |
| Pictograms | GHS07 |
| Signal word | Warning |
| Hazard statements | No known significant effects or critical hazards. |
| Precautionary statements | P264, P270, P301+P312, P330, P501 |
| Autoignition temperature | 350 °C |
| Lethal dose or concentration | Lethal dose or concentration (LD50/LC50) for Polyethylene Oxide: "LD50 (oral, rat) > 2000 mg/kg |
| LD50 (median dose) | > 6,500 mg/kg (rat, oral) |
| NIOSH | RN 25322-68-3 |
| PEL (Permissible) | Not established |
| REL (Recommended) | 0.05 mg/m³ |
| IDLH (Immediate danger) | Not listed |
| Related compounds | |
| Related compounds |
Polyethylene glycol Polypropylene glycol Polyvinyl alcohol Polyacrylamide Polyethylene Polypropylene |
| Related compounds |
Polyethylene glycol Polypropylene glycol Polyvinyl alcohol Polyacrylamide Polyethylene Polyoxymethylene |