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Product Name: Polyethylene Glycol 400
Synonyms: PEG 400, Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-
Chemical Family: Polyether compound
CAS Number: 25322-68-3
Recommended Use: Solvents, cosmetics, pharmaceuticals, lubricants, chemical synthesis
Supplier Identification: [Manufacturer Name & Address]
Emergency Telephone: [Supplier Emergency Number]
GHS Classification: Not classified as hazardous under GHS
Main Hazards: Slight eye irritation possible, may cause mild skin irritation after prolonged exposure; low acute toxicity
Pictogram: None required
Signal Word: None
Precautionary Statements: Avoid prolonged contact with skin and eyes; avoid breathing vapors or mists
Other Hazards: Slippery when spilled, poses slip hazard at workplace
Chemical Name: Polyethylene Glycol 400
CAS Number: 25322-68-3
Content: 99–100% by weight
Other Ingredients: No additives or impurities known to contribute to hazard
Inhalation: Remove person to fresh air if symptoms occur; offer symptomatic treatment for mild irritation
Skin Contact: Wash skin thoroughly with soap and water; remove contaminated clothing
Eye Contact: Rinse eyes immediately with plenty of water for 15 minutes; seek medical attention if irritation develops
Ingestion: Rinse mouth with water; drink small quantity of water; seek medical advice if feeling unwell
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray
Unsuitable Media: Strong water jet may spread product
Special Hazards: May release carbon monoxide, carbon dioxide under fire conditions
Protective Equipment: Wear self-contained breathing apparatus and protective clothing
Specific Methods: Cool containers exposed to fire with water spray to prevent bursting
Personal Precautions: Use personal protective equipment to prevent contact with skin and eyes; avoid creating slippery walking surfaces
Environmental Precautions: Prevent spillage from entering drains, soil, or waterways
Methods for Cleanup: Absorb spill with inert materials (sand, earth); collect and place in suitable closed container; wash area with water after removal
Safe Handling Advice: Use in well-ventilated areas; avoid inhalation and repeated skin contact; open and handle containers with care
Storage Conditions: Store in tightly sealed, labeled containers in cool, dry place; keep away from strong oxidizers
Incompatible Materials: Avoid contact with strong acids, strong bases, and oxidizing agents
Special Requirements: Store away from direct sunlight and excessive heat; avoid freezing
Occupational Exposure Limits: No established exposure limits
Engineering Controls: Use local exhaust ventilation or other engineering controls if vapor or mist generation exceeds allowable concentrations
Personal Protective Equipment: Chemical-resistant gloves, eye protection (goggles or face shield), protective clothing
Hygiene Measures: Wash hands after handling; avoid eating, drinking, or smoking during use
Appearance: Clear, colorless, viscous liquid
Odor: Slight odor
Odor Threshold: Not established
pH: 5–7 for aqueous solution (10%)
Melting Point/Freezing Point: -20°C to -10°C
Initial Boiling Point and Range: 250°C (482°F)
Flash Point: 204°C (399°F) (closed cup)
Evaporation Rate: Negligible
Flammability (solid, gas): Not flammable
Upper/Lower Flammability or Explosive Limits: Not determined
Vapor Pressure: <0.01 mmHg at 20°C
Vapor Density: >1 (air = 1)
Relative Density: 1.125–1.130 g/cm³ at 20°C
Solubility: Completely miscible with water
Partition Coefficient (n-octanol/water): log Kow ≈ -1.75
Auto-Ignition Temperature: >370°C
Decomposition Temperature: >200°C
Viscosity: 90–110 mPa·s at 20°C
Molecular Weight: Averages from 380 to 420 g/mol
Stability: Stable under recommended storage and handling conditions
Reactivity: Inactive under normal conditions of use
Possibility of Hazardous Reactions: None expected under normal conditions
Conditions to Avoid: Excessive heat, direct sunlight, freezing temperatures
Incompatible Materials: Strong oxidizers, strong acids, strong bases
Hazardous Decomposition Products: Fumes containing carbon monoxide, carbon dioxide produced on combustion or thermal decomposition
Acute Toxicity - Oral (LD50): Approximately 30,000 mg/kg (rat)
Skin Irritation: Mild irritation possible after prolonged contact
Eye Irritation: Minimal irritation, not expected to cause significant effects
Sensitization: Not known to cause sensitization
Chronic Effects: No evidence of carcinogenic, mutagenic, or reproductive toxicity
Other Information: Generally recognized as safe at recommended exposures
Ecotoxicity: Not considered harmful to aquatic life at typical concentrations
Aquatic Toxicity (Fish): LC50 (96 h): >1,000 mg/L
Persistence and Degradability: Readily biodegradable in the environment
Bioaccumulative Potential: Low, based on log Kow
Mobility in Soil: Very high, substance migrates easily in soil due to high water solubility
Other Adverse Effects: No significant environmental hazards identified
Waste Treatment Methods: Dispose according to local, regional, national regulations for non-hazardous chemical waste
Disposal of Product: May be disposed of in wastewater treatment plants when diluted, provided compliance with local discharge regulations
Disposal of Contaminated Packaging: Empty containers can be taken to an approved waste handling site for recycling or disposal
Do Not: Discharge concentrated material directly to waterways, sewers or soil
UN Number: Not regulated
UN Proper Shipping Name: Not applicable
Transport Hazard Class: Not classified
Packing Group: Not applicable
Environmental Hazards: Not considered hazardous for transport
Special Precautions: Prevent leaks during transport; keep in original container
OSHA Status: Not hazardous as defined by OSHA Hazard Communication Standard
TSCA Inventory: Listed
DSL/NDSL (Canada): Listed
REACH (EU): Registered
SARA 313: Not listed
California Prop 65: Not listed
Other Regulations: Complies with cosmetic, pharmaceutical, and food contact regulations when applicable; check with regional authorities for specific uses
