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Material Safety Data Sheet: Phosphatidyl Cholines

1. Identification

Product Name: Phosphatidyl Choline
Synonyms: Lecithin, PtdCho
Chemical Family: Phospholipids
CAS Number: 8002-43-5 (mixed source Lecithin)
Intended Use: Emulsifier, pharmaceutical and food additive, cosmetic ingredient, nutraceutical component
Manufacturer Details: Manufacturer’s name, complete address, phone number, email contact
Emergency Number: Local and regional emergency contacts

2. Hazard Identification

Classification: Non-hazardous according to GHS criteria
Physical Hazards: Not classified
Health Hazards: May be mildly irritating to eyes or skin in concentrated forms or dust
Environmental Hazards: Not expected to be toxic to environment
Signal Words: None required
Hazard Pictograms: None
Precautionary Statements: Avoid inhalation of dust and contact with eyes; keep containers tightly sealed

3. Composition / Information on Ingredients

Main Components: Phosphatidyl choline ~60-95% (CAS: 8002-43-5)
Associated Compounds: Other phospholipids (e.g., phosphatidylethanolamine, phosphatidylinositol), triglycerides & fatty acids (1-35%)
Additives: Minor stabilizers or antioxidants such as tocopherols possible
Impurities: Trace residual protein and carbohydrates depending on the source
Formulation: Liquid or powder, may be blended with carrier substances for food or pharmaceutical formulations

4. First Aid Measures

Eye Contact: Rinse cautiously with water for at least 10 minutes. Remove contact lenses if present and easy to do. Seek medical advice if discomfort persists.
Skin Contact: Wash with soap and water. Seek medical attention for irritation or allergic symptoms.
Inhalation: Move to fresh air. Rinse nose and throat with water if discomfort occurs. Seek medical advice if symptoms continue.
Ingestion: Rinse mouth with water. Give water to drink. If feeling unwell, get medical aid.
Acute Symptoms: Minor irritation expected only at unusually high exposures or through allergic response

5. Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray
Unsuitable Extinguishing Media: Strong water jets—may spread burning material
Specific Hazards from Fire: Burning may produce oxides of carbon and phosphorus compounds
Protective Equipment: Firefighters require full protective gear, including self-contained breathing apparatus
Special Precautions: Prevent contaminated firefighting water from entering drains or watercourses

6. Accidental Release Measures

Personal Precautions: Provide adequate ventilation; wear protective equipment to avoid eye contact and skin exposure. For powders, use a dust mask or respirator.
Environmental Precautions: Prevent product from entering watercourses or sewers in bulk.
Cleanup Methods: Absorb liquid spills with sand, earth or inert material and collect in suitable containers. Sweep up powder carefully to avoid dust generation. Clean surface thoroughly with water and detergent.
Special Instructions: Wash heavily exposed skin and clean contaminated clothing before reuse

7. Handling and Storage

Safe Handling: Use with adequate ventilation. Avoid formation of dust. Wear gloves and safety glasses in processing areas.
Storage: Store in tightly closed containers in a cool, dry location away from light, heat, and incompatible materials (oxidizers).
Conditions to Avoid: Elevated temperatures, damp or humid environments, exposure to strong oxidizing agents
Packaging Materials: Use food or pharmaceutical grade containers to avoid contamination

8. Exposure Controls / Personal Protection

Workplace Exposure Limits: No established OSHA or ACGIH exposure limits for lecithin or pure phosphatidyl choline
Engineering Controls: General ventilation sufficient; for powder or dust handling, use local exhaust
Respiratory Protection: Dust mask or respirator for processes generating airborne powders
Skin Protection: Nitrile or latex gloves where skin contact is likely in bulk use
Eye Protection: Safety glasses or goggles recommended in production areas
Hygiene Measures: Wash hands thoroughly after handling; avoid contact with eyes, skin and clothing

9. Physical and Chemical Properties

Appearance: Light brown to yellow viscous liquid or pale powder
Odor: Mild, characteristic fatty odor
pH: Not applicable (insoluble in water)
Melting Point: 20–30°C (typical for commercial lecithin)
Boiling Point: Decomposes before boiling
Flash Point: >150°C (non-volatile, low fire risk)
Flammability: Not highly flammable, but combustible
Solubility: Practically insoluble in water, soluble in chloroform, ethanol, ether
Viscosity: Highly viscous (liquid form)
Oxidizing Properties: Not an oxidizer
Density: 1.03–1.07 g/cm³ (liquid form)

10. Stability and Reactivity

Chemical Stability: Stable under normal temperatures and storage conditions
Reactivity: Generally unreactive
Conditions to Avoid: Excessive heat, strong oxidizers, exposure to sunlight
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition Products: May release carbon oxides and phosphorus compounds if burned
Polymerization: Will not occur

11. Toxicological Information

Acute Toxicity: Not acutely toxic by oral, dermal or inhalation routes
Irritation: Slight irritation possible to eyes and skin, mainly with dust or bulk exposure
Sensitization: Rarely, allergic reactions in sensitive individuals
Chronic Effects: No evidence of chronic toxicity under typical levels of exposure
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, or OSHA
Reproductive Toxicity: No known effects

12. Ecological Information

Ecotoxicity: Not expected to be harmful to aquatic life at standard concentrations
Persistence and Degradability: Readily biodegradable
Bioaccumulation Potential: Low, due to degradation and metabolism
Mobility in Soil: Immobile, binds to soil and organic material
Other adverse effects: None known based on currently available data

13. Disposal Considerations

Waste Treatment Methods: Dispose in accordance with federal, state and local regulations.
Product Disposal: Incinerate or landfill in approved facility if permitted.
Contaminated Packaging: Clean containers thoroughly or dispose of as chemical waste.
Special Precautions: Prevent entry to waterways or sewers with bulk material

14. Transport Information

UN Number: Not classified as hazardous for transportation
Transport Hazard Class(es): None
Packing Group: Not applicable
Special Precautions for User: Avoid container breakage; keep well sealed
Environmental Hazards: Not classified as environmentally hazardous

15. Regulatory Information

Inventory Listings: Listed in chemical inventories such as TSCA (US), EINECS (EU), DSL (Canada)
Regulatory Status: Approved as a food and pharmaceutical additive by FDA, EFSA and similar agencies
Labeling Requirements: Not required to bear hazard labels under OSHA, GHS, or CLP
Other Regulations: Product must conform to standards for food or pharmaceutical use, as applicable to specific grade
Worker Protection: Occupational health and safety laws apply
Restrictions: Ensure use is consistent with intended application and purity grades