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Material Safety Data Sheet: Phaffia Rhodozyma

Identification

Product Name: Phaffia rhodozyma
Synonyms: Astaxanthin-producing yeast
CAS Number: 89728-95-0
Recommended Use: Feed additive, pigment producer, research ingredient
Supplier: Details available from manufacturer documentation
Contact for Emergencies: Listed emergency telephone numbers, staffed 24 hours

Hazard Identification

Classification: Biological substance, not considered hazardous in normal use
GHS Label Elements: No pictogram required
Signal Word: None
Hazard Statements: Not expected to cause health concerns when handled correctly
Precautionary Statements: Avoid creating dusty conditions, prevent unnecessary exposure, maintain proper hygiene
Potential Health Effects: Low risk by inhalation, ingestion, and skin contact; those with yeast allergies may experience local reactions

Composition / Information on Ingredients

Chemical Nature: Living dried yeast, Phaffia rhodozyma cells
Purity: Exceeds 99% dried biological material
Impurities: Small traces of residual growth media and water
Sensitizers: Protein components and cell wall fragments may act as minor allergens
Active Component: Astaxanthin (natural pigment)

First Aid Measures

Inhalation: Move affected person to fresh air, monitor for respiratory irritation, obtain medical advice if symptoms persist
Skin Contact: Wash area thoroughly with soap and water, remove contaminated clothing, seek consultation if rash forms
Eye Contact: Rinse carefully for several minutes with water, remove contact lenses when easy, continue rinsing and seek care if irritation develops
Ingestion: Rinse mouth, give water to drink, do not induce vomiting, consult a physician for discomfort or other symptoms
Major Symptoms: Mild irritation, redness, coughing for sensitive individuals

Fire-Fighting Measures

Suitable Extinguishing Methods: Use dry chemical, foam, carbon dioxide, or water spray
Hazards from Combustion: Product may burn and release carbon dioxide, carbon monoxide, and minor organic fumes
Personal Protective Equipment: Wear self-contained breathing apparatus, full protective gear
Additional Information: Dust produced from dried powder may present slight risk of dust explosion in enclosed areas

Accidental Release Measures

Personal Precautions: Wear gloves and mask to prevent skin and respiratory exposure
Environmental Precautions: Prevent spill from entering drains or waterways, collect any spilled product immediately
Cleanup Methods: Sweep up carefully to avoid raising dust, use damp cloth or vacuum with HEPA filter, dispose in sealed bag or container
Decontamination: Wash site with water after collection

Handling and Storage

Safe Handling Advice: Avoid creating dust, use with proper ventilation, do not eat or smoke during handling
Storage Requirements: Store in tightly closed container in cool, dry, well-ventilated place, shield from light and moisture
Incompatibilities: Do not store near strong acids, bases, oxidizing agents
Hygienic Measures: Wash hands and face after handling, keep away from food and drink

Exposure Controls and Personal Protection

Exposure Limits: No established occupational limits for Phaffia rhodozyma
Engineering Controls: Local exhaust ventilation recommended to reduce airborne dust
Personal Protective Equipment: Respiratory – NIOSH-approved mask for dusty conditions; Skin – disposable gloves; Eyes – safety glasses or goggles; Clothing – standard laboratory coat or coveralls
Environmental Measures: Workplace monitoring for airborne yeast dust may be necessary during large-scale use

Physical and Chemical Properties

Appearance: Reddish-orange to pink powder or granules
Odor: Slightly musty or yeast-like
Odor Threshold: Not determined
pH (in water): Approximately 5.0 to 7.0
Melting/Freezing Point: Not applicable (biological material)
Boiling Point: Not applicable
Flash Point: Not measurable
Evaporation Rate: Not applicable
Solubility: Insoluble in water; dispersible when agitated
Flammability: Dust may be combustible in high concentrations
Particle Size: Fine powder/granules
Bulk Density: 0.3 – 0.7 g/cm³
Vapor Pressure/Vapor Density: Not relevant

Stability and Reactivity

Stability: Remains stable under recommended storage conditions
Reactivity: Does not react with typical construction materials or packaging
Possibility of Hazardous Reactions: Negligible
Conditions to Avoid: Excessive moisture, direct sunlight, heating above 37°C
Incompatible Materials: Strong oxidizers and acids
Hazardous Decomposition Products: Natural degradation yields carbon dioxide, water, traces of organics
Polymerization: No risk

Toxicological Information

Acute Toxicity: Low oral toxicity based on available data, large doses may cause mild GI upset
Skin Corrosion/Irritation: Does not irritate intact skin under normal conditions, irritation possible for sensitive persons
Serious Eye Damage/Irritation: May cause mild transient irritation
Respiratory Sensitization: Potential for slight allergic response in predisposed individuals
Carcinogenicity: Not classified as carcinogenic in humans or animals
Mutagenicity: No genotoxic effects in standard tests
Chronic Effects: No evidence for long-term health risk from occupational exposure

Ecological Information

Eco-toxicity: Not anticipated to cause environmental damage under normal use
Persistence and Degradability: Readily biodegrades in natural environments
Bioaccumulation Potential: No significant tendency to accumulate in living organisms
Mobility in Soil: Limited movement; binds to soil organic matter
Other Adverse Effects: Minimal risk to aquatic or terrestrial life at realistic concentrations

Disposal Considerations

Waste Disposal Methods: Dispose with standard compostable/organic waste if permitted, or by incineration according to local regulations
Contaminated Packaging: Recycle or dispose as non-hazardous waste after cleaning
Special Precautions: Avoid release of not-fully inactivated cultures to wild ecosystems

Transport Information

UN Number: Not regulated as dangerous goods
UN Proper Shipping Name: Not required
Transport Hazard Class: Non-hazardous material
Packing Group: Not assigned
Environmental Hazards: None identified
Special Precautions for User: Package in tightly closed, leak-proof containers to minimize dust release
Bulk Transport Guidance: Maintain dry conditions and limit vibration

Regulatory Information

TSCA Status: Listed under EPA requirements as a biological material
REACH Registration: Not applicable; living microorganisms exempt in EU
OSHA Requirement: Not specifically regulated
WHMIS Classification (Canada): Exempt, non-hazardous biological
Other Regulations: Observe country-specific biosafety rules, particularly for use as animal feed ingredient
Labeling Requirements: Declaration of live microorganisms, non-pathogenic status statements
Product Registration: Requires notification or approval in several jurisdictions for use in food or feed