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Product Name: Papain
Chemical Name: Papain, Papaya proteinase I
Synonyms: Papaya enzyme, Vegetable pepsin
CAS Number: 9001-73-4
Recommended Usage: Used in food processing, brewing, pharmaceuticals, cosmetics, meat tenderizing, and detergents.
Manufacturer Information: Sourced from Carica papaya latex; specific supplier contact details provided on manufacturer’s website or technical sheet.
Emergency Contact: Refer to local poison control center, emergency medical services, and supplier's emergency line.
Product Description: Typically appears as a fine, off-white to light beige powder; mild, characteristic odor.
GHS Classification: Eye Irritation – Category 2A, Respiratory Sensitizer – Category 1, Skin Sensitizer – Category 1.
Signal Word: Danger
Hazard Statements: Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction.
Precautionary Statements: Avoid breathing dust; use only outdoors or in a well-ventilated area. Wear protective gloves, eye protection, and face protection. Wash skin thoroughly after handling. If on skin or in eyes, rinse with plenty of water.
Potential Health Effects: Inhalation leads to respiratory discomfort or allergic symptoms. Skin contact can result in irritation or allergic dermatitis. Eye exposure produces pain, redness, and watering. Ingestion may induce mild gastrointestinal upset.
Main Ingredient: Papain (Proteinase from Carica papaya latex)
Concentration: Typically 95-100% active enzyme protein, with residual moisture.
Impurities/Additives: May contain negligible quantities of plant carbohydrates and salts. No hazardous impurities present at reportable concentrations under GHS.
CAS Number: 9001-73-4
EC Number: 232-627-2
General Advice: Seek immediate medical attention for serious symptoms of allergy, respiratory issues, or if symptoms persist.
Inhalation: Move person to fresh air. If breathing problems or allergic reaction arise, medical intervention is warranted. Administer oxygen if severe shortness of breath.
Skin Contact: Remove contaminated clothing and wash affected area with soap and water. If rash, redness, or irritation develops, get medical help.
Eye Contact: Flush with running water for at least 15 minutes, lifting upper and lower eyelids occasionally. Do not rub eyes. Medical evaluation for pain, redness, or blurred vision.
Ingestion: Rinse mouth water, avoid inducing vomiting. Medical assistance if large quantities ingested or symptoms occur.
Advice for Physicians: Treat symptomatically. Pulmonary sensitization and dermal reactions should be managed as per allergy protocol.
Suitable Extinguishing Media: Dry chemical, CO2, foam, or water spray. Select agents suited for surrounding fire.
Unsuitable Extinguishing Media: None specified for product; avoid heavy water streams where safe to do so.
Specific Hazards: Organic powder can form combustible dust clouds; risk of explosion if dispersed in air and exposed to ignition. Thermal decomposition yields oxides of carbon and nitrogen.
Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective clothing. Avoid inhaling combustion products.
Special Precautions: Use water to cool containers exposed to fire. Prevent runoff from entering watercourses or drains.
Personal Precautions: Avoid breathing dust; ventilate area adequately. Use respiratory protection suited for particulate. Prevent further release or dispersal of dust.
Environmental Precautions: Avoid discharge to drains, surface water, or soil due to risk of enzyme sensitization for aquatic organisms.
Methods for Containment: Sweep up and collect spilled material carefully to minimize dust. Place in suitable, labeled containers for disposal.
Cleanup Procedures: Use damp cloth or mop for final residues. Clean affected area with water and detergent. Dispose in accordance with local regulations.
Safe Handling Notes: Minimize dust generation. Wear recommended protective equipment including gloves, eye/face protection, and local exhaust ventilation or dust extraction systems. Do not eat or drink in areas of use; wash hands after handling.
Safe Storage Conditions: Store tightly sealed in original container in a dry, cool, and ventilated location. Protect from moisture, heat sources, and direct sunlight. Segregate from incompatible chemicals such as strong oxidizers.
Incompatibilities: Strong oxidizing agents can degrade enzymes.
Specific Requirements: Keep away from children and unauthorized personnel. Do not transfer contents to unlabelled or inappropriate containers.
Exposure Limits: No occupational exposure limits set for papain; treat as nuisance dust or inhalational allergen.
Engineering Controls: Local exhaust ventilation, enclosed processes, or dust collection systems recommended for bulk handling.
Respiratory Protection: NIOSH-approved particulate respirator or P2/P3 filter where dust levels exceed comfort threshold or in cases of allergy risk.
Skin Protection: Chemical-resistant gloves (nitrile, latex), long-sleeved garments.
Eye and Face Protection: Safety goggles with side shields or face shield.
Other Protective Measures: Emergency eyewash station and shower in work area.
Appearance: Fine, off-white to pale yellow powder.
Odor: Faint, papaya-like characteristic odor.
Odor Threshold: Not determined.
pH: 5.5 – 7.0 (1% solution in water).
Melting Point/Freezing Point: Not applicable (protein denatures before melting).
Boiling Point: Not applicable; decomposes before boiling.
Flash Point: Not applicable.
Evaporation Rate: Not available.
Flammability: Dust may be combustible under certain conditions.
Vapor Pressure: Not applicable.
Vapor Density: Not applicable.
Relative Density: About 1.30 g/cm³.
Solubility in Water: Readily soluble, yields clear to slightly turbid solution.
Partition Coefficient (n-octanol/water): Not determined.
Auto-ignition Temperature: No data.
Decomposition Temperature: >150°C, changes to brown and loses enzymatic activity.
Viscosity: Not applicable.
Chemical Stability: Stable under recommended storage conditions.
Reactivity: Non-reactive under normal use; reactive with strong oxidizers.
Hazardous Reactions: Dust explosion possible if dispersed in air under high energy ignition.
Conditions to Avoid: Damp or humid storage promotes microbial growth and enzyme degradation. Avoid strong heat sources and open flames.
Incompatible Materials: Strong acids, alkalis, and oxidizing agents.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides upon thermal decomposition.
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion.
Acute Toxicity: Oral LD50 (rat): >10,000 mg/kg; essentially non-toxic.
Inhalation: Respiratory tract irritation, asthma, sensitization may occur.
Dermal: Sensitization and irritation risk in susceptible persons.
Ocular: Causes irritation, pain, and tearing.
Chronic Effects: Occupational asthma with repeated exposure. Skin allergy possible after repeated or prolonged contact.
Carcinogenicity: Not classified as carcinogenic by IARC, OSHA, or NTP.
Mutagenicity/Teratogenicity: No known mutagenic or teratogenic potential.
Other Data: Symptoms in allergic individuals can include chest tightness, runny nose, rash.
Ecotoxicity: Enzymatic proteins degrade readily in environment, low acute aquatic toxicity.
Persistence and Biodegradability: Papain breaks down quickly to harmless amino acids under environmental conditions.
Bioaccumulative Potential: No bioaccumulation expected.
Mobility in Soil: High solubility in water; not likely to bind to soil tightly.
Other Adverse Effects: Localized irritation may affect soil and water organisms in cases of significant contamination.
Waste Disposal Methods: Collect and contain material for disposal as non-hazardous organic waste, or via approved chemical waste disposal contractor. Avoid uncontrolled release to environment or drains.
Container Disposal: Triple-rinse and treat containers as municipal waste with all enzyme residues deactivated. Comply with local, regional, and national regulations.
Special Precautions: Do not incinerate closed, uncleaned containers.
UN Number: Not classified as dangerous goods for transport.
Proper Shipping Name: Not restricted.
Transport Hazard Class: Not hazardous.
Packing Group: Not applicable.
Marine Pollutant: Not regulated as a marine pollutant.
Special Transport Precautions: Avoid conditions that promote dust formation during loading/unloading. Ensure containers are tightly sealed and protected from damages.
Inventory Listings: Registered in major chemical inventories (TSCA, EINECS, DSL).
Labelling Requirements: Complies with GHS for hazard communication – contains necessary hazard pictograms and hazard statements.
Workplace Regulation Compliance: Occupational exposure and enzyme handling subject to standard industry and regional regulations.
Restrictions: Suitable for use as a processing aid or ingredient in food, pharmaceutical, and cosmetic applications if following good manufacturing practices.
Other Regulations: No significant risks under normal use with standard safety measures. Subject to chemical hygiene plan in laboratory and manufacturing settings.
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
