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West Ujimqin Banner, Xilingol League, Inner Mongolia, China
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Product Name: Nisin
Chemical Formula: C143H230N42O37S7
Synonyms: E234, Nisin A
Recommended Use: Food preservative, anti-microbial agent
Manufacturer: Provide name and address of supplier or manufacturing company
Emergency Contact: Indicate specific phone number for emergencies
CAS Number: 1414-45-5
Relevant Identified Uses: Applied in dairy products, canned foods, processed cheeses, meats
Restrictions on Use: Only for approved food-grade applications
GHS Classification: Not classified as hazardous according to GHS criteria
Signal Word: No signal word assigned
Hazard Statements: Non-irritant to skin and eyes under typical handling
Pictograms: None
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Potential Acute Effects: Dust may cause mild respiratory irritation
Potential Chronic Effects: No evidence for chronic toxicity in humans
Precautionary Statements: Handle with reasonable industrial hygiene practices
Other Hazards: May present a dust explosion risk in fine powders
Component: Nisin
Concentration: ≥ 2.5% pure nisin (commercial preparations), rest sodium chloride and food-grade diluents
Chemical Nature: Polycyclic antibacterial peptide
Impurities: No relevant impurities expected in food-grade product
Molecular Weight: About 3354 Da (Nisin A)
Inhalation: Remove individual to fresh air, consult physician if symptoms develop
Skin Contact: Wash affected area thoroughly with soap and water
Eye Contact: Rinse eyes immediately with gentle water flow for several minutes, seek attention for irritation
Ingestion: Rinse mouth with water, seek medical advice if discomfort occurs
Advice for Physicians: Treat symptomatically, no known antidote required
Suitable Extinguishing Media: Use water spray, foam, carbon dioxide (CO₂), or dry chemical
Unsuitable Extinguishing Media: None known for this material
Specific Hazards: Fine dust may generate explosive air/dust mixtures
Thermal Decomposition Products: Carbon oxides, nitrogen oxides, sulfur oxides
Protective Equipment for Fire Fighters: Full protective gear and self-contained breathing apparatus recommended
Advice: Avoid inhalation of combustion products, evacuate area if necessary
Personal Precautions: Wear gloves, mask, eye protection to prevent contact with dust
Environmental Precautions: Prevent large quantities from entering waterways
Methods for Cleaning Up: Sweep or vacuum up material, avoid generating dust, place in suitable container for disposal
Reference to Other Sections: For disposal see "Disposal Considerations" section
Handling: Use in well-ventilated area, avoid breathing dust, avoid direct skin and eye contact
Technical Measures: Ground/bond containers and transfer equipment to prevent static accumulation
Specific Use(s): Use according to approved food regulations
Storage Conditions: Store in cool, dry location, tightly sealed and protected from light
Storage Incompatibilities: Avoid moisture and strong oxidizing agents
Packaging Materials: Use food-grade, tightly-sealed containers
Control Parameters: No established occupational exposure limits
Engineering Controls: Ventilation systems to minimize dust in processing areas
Personal Protective Equipment: Gloves (nitrile or latex), safety goggles, dust mask in dusty environments
Hygiene Measures: Wash hands thoroughly after handling, avoid food and drink in workplace
Environmental Exposure Controls: Prevent uncontrolled release to the environment
Appearance: Off-white to light yellow powder
Odor: Slight, characteristic odor
Odor Threshold: Not established
pH: 3.0 – 4.5 (10% solution)
Melting Point: Decomposes before melting
Boiling Point: Not applicable (decomposes)
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Not classified as flammable, dust may be combustible
Solubility: Soluble in water, forms clear solution
Partition Coefficient (n-octanol/water): Not available
Vapor Pressure: Negligible
Relative Density: ~1.5 g/cm³
Particle Size: Typically micron-scale in commercial products
Reactivity: Chemically stable under normal conditions
Chemical Stability: Stable in original packaging when stored at recommended conditions
Hazardous Reactions: None expected during normal handling and use
Incompatible Materials: Strong oxidizers
Hazardous Decomposition Products: Produces carbon oxides, nitrogen oxides, sulfur oxides on thermal decomposition
Conditions to Avoid: Moisture, excessive heat, strong oxidizing conditions
Acute Toxicity: Oral LD50 (rat) > 5000 mg/kg, low toxicity for humans
Skin Corrosion/Irritation: Not expected to cause irritation under normal use
Serious Eye Damage/Irritation: Not expected to cause eye damage
Respiratory Sensitization: Prolonged inhalation may cause mild irritation
Skin Sensitization: No reports of sensitization reactions
Germ Cell Mutagenicity: No mutagenic effects recorded
Carcinogenicity: Not recognized as carcinogenic by IARC, NTP, OSHA
Reproductive Toxicity: No evidence of reproductive toxicity in animal studies
STOT-Single Exposure: No relevant data
STOT-Repeated Exposure: No relevant data
Aspiration Hazard: Not an aspiration hazard
Ecotoxicity: Not expected to be hazardous to aquatic or terrestrial environments at typical use levels
Persistence and Degradability: Rapidly biodegradable by soil and water microorganisms
Bioaccumulative Potential: No potential for bioaccumulation
Mobility in Soil: Expected to be highly mobile, decomposes readily
Other Adverse Effects: No known negative effects on environment
Product Disposal: Small amounts may be flushed to sewer with plenty of water per local regulations, larger quantities to be disposed in accordance with local, regional, and national laws
Container Disposal: Triple rinse containers, dispose as per regulations, recycle where possible
Uncleaned Packaging: Dispose of as unused product
Special Precautions: Avoid dust generation during disposal
Waste Codes: Assign according to local waste management policies
UN Number: Not regulated as dangerous goods
UN Proper Shipping Name: Not classified
Transport Hazard Class: Not assigned
Packing Group: None
Environmental Hazards: Not considered marine pollutant
Special Precautions: Avoid packaging that creates excess dust, store securely during transit
Food Additive Status: Approved globally as E234 by EU, permitted by FDA as GRAS in the USA
OSHA Status: Not regulated as hazardous substance
TSCA Status: Listed
DSL/NDSL (Canada): Listed
REACH Status (Europe): Exempt as food additive
Other National Inventories: Compliant with the respective national food safety systems
Labeling Requirements: Must be labeled as “Nisin” or “E234” where used in food
Additional Notes: Observe local, regional, national, and international regulations as applicable
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
