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West Ujimqin Banner, Xilingol League, Inner Mongolia, China
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Product Name: Nicotinic Acid
SYNONYMS: Niacin, Pyridine-3-carboxylic acid, Vitamin B3
CAS Number: 59-67-6
Molecular Formula: C6H5NO2
Molecular Weight: 123.11 g/mol
Manufacturer: Refer to specific supplier for contact details
Recommended Use: Pharmaceutical intermediate, nutritional supplement, food fortifier
Emergency Contact: Refer to local regulatory guidelines for poison control and emergency medical assistance
Classification: Not classified as hazardous under GHS regulations in most jurisdictions
Potential Health Effects: Inhalation, ingestion, or skin contact can cause irritation; high doses may result in flushing, nausea, dizziness, headache; chronic overexposure linked to liver and gastrointestinal issues
Label Elements: Not required for non-hazardous classification, but precautionary statements are necessary for workplace safety
Signal Word: No signal word for standard handling
Hazard Statements: Causes mild skin and eye irritation upon direct contact
Precautionary Statements: Avoid breathing dust; wash hands thoroughly after handling; use personal protective equipment as required
Other Hazards: Dust from product might form explosive mixtures with air under certain conditions
Substance: Nicotinic Acid
Chemical Identity: 100% pure, batch-dependent minor impurities possible
CAS Number: 59-67-6
EC Number: 200-441-0
Other Ingredients: None anticipated based on standard material specifications
Inhalation: Move person to fresh air; provide oxygen or artificial respiration as needed; seek medical attention if symptoms persist
Skin Contact: Rinse with soap and plenty of water; remove contaminated clothing; medical attention for persistent irritation
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present; seek medical advice if irritation develops
Ingestion: Rinse mouth with water; do not induce vomiting; seek immediate medical support if symptoms develop or if ingested in significant quantities
Acute Symptoms: Flushing, burning sensation, gastrointestinal discomfort
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical, foam
Unsuitable Media: Do not use strong water jets, as powder can become airborne
Hazardous Combustion Products: Fumes containing nitrogen oxides, carbon oxides, and other irritating or toxic vapors
Firefighting Instructions: Wear self-contained breathing apparatus and full protective gear; prevent runoff from contaminating water supplies
Flash Point: Approximately 230°C (446°F)
Explosion Limits: Dust explosion possible in fine particle clouds with air
Personal Precautions: Use personal protective equipment; avoid dust formation and inhalation; evacuate unnecessary personnel from affected area
Environmental Precautions: Prevent product from reaching drains, sewers, or natural water sources; inform appropriate authorities of large releases
Spill Cleanup Methods: Sweep up without generating dust; absorb with suitable inert material; transfer to properly labeled containers for disposal
Decontamination: Clean spill site with water after material pickup; ventilate area
Safe Handling Guidelines: Handle in well-ventilated areas; avoid breathing dust or vapor; wash thoroughly after handling
Technical Measures: Use local exhaust ventilation; ground equipment handling powder to avoid ignition
Storage Conditions: Store in tightly sealed containers, in a cool, dry, well-ventilated area; protect from moisture and incompatible substances
Incompatibilities: Strong oxidizing agents, strong bases; avoid contact with reactive metals
Specific Use(s): Food, pharmaceutical, and industrial applications under sound laboratory procedures
Occupational Exposure Limits: Not established for nicotinic acid; use general dust exposure guidelines (<10 mg/m3 for nuisance dust)
Engineering Controls: Adequate ventilation, dust collection, process enclosures
Personal Protective Equipment (PPE): Safety goggles, gloves (nitrile or latex), lab coat, particulate respirator in case of high dust concentrations
Hygiene Measures: No eating, drinking, or smoking in work area; thorough hand washing after handling
Appearance: White crystalline powder
Odor: Odorless or slight characteristic odor
pH (1% Solution): About 3.0–4.0
Melting Point: 236–239°C
Boiling Point: Decomposes before reaching boiling point
Solubility in Water: 15 g/L (25°C)
Solubility in Other Solvents: Slightly soluble in ethanol, practically insoluble in ether and chloroform
Density: 1.47 g/cm³
Vapor Pressure: Negligible
Partition Coefficient (n-octanol/water): 0.36
Auto-ignition Temperature: 504°C
Explosive Properties: Not explosive, but dust may pose explosion hazard
Chemical Stability: Stable at recommended storage conditions
Reactivity: No dangerous reactions under normal conditions
Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide
Possibility of Hazardous Reactions: Exothermic reaction with strong oxidizers; may cause fire hazard
Incompatible Materials: Strong oxidizing agents, bases, alkali metals
Conditions to Avoid: Moisture, heat, sources of ignition, static discharge
Acute Toxicity: Oral LD50 (rat): approx. 3500 mg/kg; data show low acute toxicity
Skin Corrosion/Irritation: Mild irritation possible on prolonged skin contact
Serious Eye Damage/Irritation: Mild to moderate irritation
Respiratory Sensitization: Not expected for single exposure, repeated or prolonged inhalation could aggravate symptoms
Carcinogenicity: Not classified as carcinogenic to humans by IARC or other agencies
Mutagenicity: No evidence in standard testing
Reproductive Toxicity: Not expected at typical exposure levels
Chronic Effects: Flushing, liver toxicity with large chronic doses, gastrointestinal disturbances
Ecotoxicity: Low toxicity to aquatic organisms; LC50 (fish, 96 h) >100 mg/L
Persistence and Degradability: Readily biodegradable in the environment
Bioaccumulation: Expected to be low, based on partition coefficient
Mobility in Soil: Moderate mobility due to water solubility
Other Adverse Effects: No significant risk in normal use and disposal
Waste Treatment Methods: Dispose via authorized chemical waste collection agency; incineration for large quantities following local, regional, and national guidelines
Waste Classification: Non-hazardous material, but avoid direct discharge to waterways or sewers
Packaging: Empty packaging and residues should follow the same disposal procedures as the substance itself
Sewage Disposal: Do not dispose into drains; contact waste disposal authority for advice
UN Number: Not regulated for transport under ADR, IMDG, IATA
Proper Shipping Name: Nicotinic Acid
Transport Hazard Class: Not classified as dangerous goods
Packing Group: Not applicable
Marine Pollutant: No
Environmental Hazards: Not environmentally hazardous under transport regulations
Special Precautions for User: Use standard handling for bulk powders to minimize dust formation and spillage
Inventory Listings: Listed in TSCA (US), EINECS/ELINCS (EU), DSL (Canada), AICS (Australia), ENCS (Japan)
TSCA Compliance: Yes
Regulations: Not subject to specific restrictions or labeling under EU REACH or OSHA Hazard Communication Standard for non-hazardous materials
Safety Assessment: No evidence of carcinogenicity per NTP, IARC, OSHA
Workplace Controls: Employers must ensure good industrial hygiene and training for all personnel exposed to the substance
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
