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West Ujimqin Banner, Xilingol League, Inner Mongolia, China
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Product Name: Neotame
Chemical Name: N-[N-(3,3-Dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine 1-methyl ester
Common Names: Neotame, Aspartame-ACE
CAS Number: 165450-17-9
Recommended Use: Artificial sweetener for food and beverage applications
Manufacturer: NutraSweet Company or other certified suppliers
Emergency Contact: Supplier emergency response line, local poison control
Address: Manufacturer’s registered location, details found on packaging
Telephone: Manufacturer's main office or support line
Classification: Not classified as hazardous under general OSHA, GHS, or EU standards
Physical Hazards: Fine dust can form combustible mixtures in air; avoid dust buildup
Health Hazards: May trigger mild irritation if inhaled or in contact with eyes, rare reports of sensitization, no evidence of carcinogenic effects in available studies
Environmental Hazards: No evidence for significant bioaccumulation or aquatic toxicity in typical quantities used
Signal Word: None required
Pictograms: Not required
Precautionary Statements: Avoid excessive inhalation of dust, use ventilation
Chemical Formula: C20H30N2O5
Purity: ≥99% by weight
Impurities: Trace levels of aspartame derivatives, solvents and process chemicals kept below 0.1%
Other Ingredients: Stabilizers possible in commercial blends but should be listed separately
Inhalation: Move to fresh air, support breathing as needed, seek medical attention if irritation continues
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing
Eye Contact: Rinse gently with plenty of water for at least 15 minutes, consult doctor if irritation develops or persists
Ingestion: Rinse mouth, drink water if conscious, seek medical advice if feeling unwell or showing allergic symptoms
Medical Attention: No specific antidote, treat symptoms supportively
Suitable Extinguishing Media: Use water spray, dry chemical, foam or carbon dioxide
Unsuitable Extinguishing Media: Direct high-pressure water jet on large powders
Specific Hazards: Fine particles may form explosive dust-air mixtures
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides
Protective Equipment: Self-contained breathing apparatus, full protective gear
Special Procedures: Evacuate area, cool containers exposed to flames with water spray
Personal Precautions: Wear dust mask, gloves, eye protection
Environmental Precautions: Prevent dust from entering drains, keep away from surface waters
Methods for Cleaning Up: Use vacuum with HEPA filter or sweep gently, avoid stirring up dust, place in sealed container for proper disposal
Reference to Other Sections: See section on Personal Protection for PPE details
Handling Precautions: Avoid creating and inhaling dust, keep containers tightly closed, handle in areas with good ventilation
Hygiene Measures: Wash hands before eating or drinking, don’t smoke in handling areas
Storage Conditions: Store in cool, dry, well-ventilated place, keep away from incompatible substances like oxidizing agents
Incompatibilities: Strong oxidizers, acids, bases could degrade product quality
Packaging Materials: Use original or chemically resistant, food grade containers
Exposure Limits: No OSHA PEL or ACGIH TLV established for Neotame
Engineering Controls: Standard room ventilation, use local exhaust for bulk handling or powder transfer
Personal Protection—Respiratory: NIOSH-approved dust mask or respirator as needed
Personal Protection—Hand Protection: Nitrile or latex gloves if repeated skin contact expected
Personal Protection—Eye Protection: Safety goggles recommended when handling powders
Environmental Control: Reduce dust emission, keep workplace clean
Appearance: White to off-white crystalline powder
Odor: Practically odorless
Odor Threshold: Not applicable
pH: Neutral in water solution
Melting Point: 81-84°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable, non-flammable solid
Evaporation Rate: Not applicable
Flammability (solid): May form explosive dust clouds
Vapor Pressure: Not volatile
Vapor Density: Not applicable
Solubility: Slightly soluble in water, more soluble in ethanol
Partition Coefficient (n-octanol/water): Not readily available, expected low bioaccumulation
Decomposition Temperature: Above 100°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended handling and storage conditions
Reactivity: Not chemically reactive under typical conditions
Conditions to Avoid: High humidity, temperatures above 100°C, static discharge
Materials to Avoid: Strong acids, bases, oxidizing agents
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides if combusted
Polymerization: Not expected under normal storage or use
Acute Toxicity: High LD50 (oral, rat) above 10,000 mg/kg, suggesting low toxicity
Chronic Toxicity: No observed adverse effect level in long-term feeding studies at expected human exposure levels
Carcinogenicity: No evidence from animal studies or IARC classification
Mutagenicity: Negative in standard genotoxicity tests
Reproductive Toxicity: No adverse effects found in reproductive studies
Sensitization: Rare reports of allergy-like symptoms
Other Information: Based on intended sweetening use, actual exposure is far below levels where adverse effects were seen in research
Ecotoxicity: Minimal toxicity to aquatic organisms at realistic environmental concentrations
Persistence and Degradability: Readily biodegradable in wastewater systems according to available data
Bioaccumulation Potential: Not likely to bioaccumulate due to high water solubility and metabolism by microorganisms
Mobility in Soil: Mobile if in dissolved phase but not likely to persist
Other Adverse Effects: Do not release large quantities into waterways, as part of good environmental hygiene
Waste Disposal Method: Dispose as non-hazardous organic waste or consult local, regional guidelines for food-related chemicals
Contaminated Packaging: Rinse and recycle or dispose in accordance with local regulations
Special Precautions: Prevent powder dispersion, avoid creating airborne dust, do not dump in surface water
Transport Regulations: Not regulated as a hazardous material by DOT, IATA, IMDG
Proper Shipping Name: Neotame, not dangerous goods
Packing Group: Not assigned
UN Number: Not assigned
Special Precautions: Use containers that prevent leakage or dusting
US Regulations: Approved by FDA for use in foods, not listed as hazardous under TSCA, SARA, or CERCLA
EU Regulations: Approved as food additive E961, not classified as hazardous for supply or transport
Other International Guidelines: Recognized by JECFA, Codex Alimentarius, and other food safety bodies
Labeling Requirements: Product labeling in line with national food safety authorities for sweeteners
Worker Protection: Follows standard workplace chemical safety regulations, not classified as occupational carcinogen
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
