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West Ujimqin Banner, Xilingol League, Inner Mongolia, China
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Product Name: Neohesperidin
Chemical Name: 4'-Methoxy-7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]flavanone
Synonyms: NHDC, Neohesperidin Dihydrochalcone
CAS Number: 13241-08-4
Recommended Uses: Used as a sweetener and flavor modifier in food, pharmaceutical, and nutraceutical industries
Supplier Information: Manufacturer’s name, address, emergency phone number, and responsible party contact details provided on shipping label
Emergency Contact Number: Reference regional chemical monitoring agency or local Poison Control
Classification: Non-flammable, non-explosive, not classified as hazardous by GHS
Hazard Statements: May cause mild skin, eye, or respiratory irritation with heavy or repeated exposure
Signal Word: None required
Pictogram: No GHS symbol assigned
Precautionary Statements: Avoid inhaling dust, contact with eyes and skin
Other Hazards: Inhalation of large amounts of powdered product may irritate respiratory passages
Chemical Identity: Neohesperidin
Purity: Greater than 95%
Impurities: Trace flavonoid impurities, moisture (less than 5%)
Molecular Formula: C28H34O15
Molecular Weight: 610.56 g/mol
Inhalation: Move person to fresh air, keep at rest, seek medical attention if symptoms persist
Skin Contact: Wash skin thoroughly with soap and water, remove contaminated clothing, seek medical guidance for irritation.
Eye Contact: Rinse cautiously with clean water for at least ten minutes, remove contact lenses, obtain medical help if discomfort persists.
Ingestion: Rinse mouth with water, drink water to dilute, seek medical attention for symptoms.
Most Important Symptoms/Effects: Mild irritation
Medical Attention/Special Treatment: Symptomatic treatment, no specific antidote available
Suitable Extinguishing Media: Foam, water spray, CO2, dry chemical powder
Unsuitable Extinguishing Media: High volume water jet if runoff may cause contamination
Specific Hazards: Product is non-flammable; decomposition releases CO, CO2, and minor volatile organics
Protective Equipment for Firefighters: Full protective gear, self-contained breathing apparatus
Special Precautions: Cool containers with water, prevent firefighting runoff from entering drains or water sources
Personal Precautions: Wear dust mask, safety goggles, gloves; avoid breathing dust
Environmental Precautions: Prevent uncontrolled release to waterways, soil, drains
Spill Cleanup Methods: Vacuum or carefully sweep up, collect into labeled containers for proper disposal
Decontamination: Wash spill area thoroughly with water after material collection
Additional Advice: Avoid raising dust clouds during cleanup
Handling Precautions: Minimize dust creation, use proper PPE, ensure adequate ventilation
Advice for Safe Handling: Avoid contact with skin, eyes and clothing; do not eat, drink, or smoke while working with material
Storage Conditions: Store sealed in original containers, cool, dry and well-ventilated place, away from direct sunlight, heat and moisture sources
Incompatible Materials: Strong oxidizing agents, strong acids or alkalis
Safe Packaging Materials: Food grade plastic or glass, tightly closed to prevent contamination and moisture uptake
Occupational Exposure Limits: No occupational exposure limits established for Neohesperidin
Engineering Controls: Local exhaust ventilation, closed handling systems recommended
Personal Protective Equipment: Chemical resistant gloves, protective clothing, safety goggles; for dust-generating processes, use NIOSH-approved respirator
Hygiene Measures: Wash hands and face after use, remove contaminated clothing, do not eat or drink where chemical is handled
Environmental Exposure Controls: Control dust emissions at source, avoid release to environment
Appearance: White to light yellow crystalline powder
Odor: Odorless
pH: 4.5 – 6.0 (10% solution in water)
Melting Point: Approximately 163°C
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Soluble in hot water, slightly soluble in cold water, insoluble in most organic solvents
Vapor Pressure: Negligible
Density: 1.55 g/cm³
Partition Coefficient (Log Kow): Not available
Flash Point: Not flammable
Auto-Ignition Temperature: Not self-ignitable
Explosive Properties: Not explosive
Chemical Stability: Stable under recommended handling and storage conditions
Reactivity: Non-reactive with most common substances
Possibility of Hazardous Reactions: Does not undergo hazardous polymerization
Conditions to Avoid: Excessive heat, light, moisture
Incompatible Materials: Strong oxidizers, acids, alkalis
Hazardous Decomposition Products: Carbon oxides, small amounts of volatile organics on thermal decomposition
Acute Toxicity: Low toxicity; oral LD50 (rat) greater than 5000 mg/kg
Skin Corrosion/Irritation: Mild irritation possible with prolonged or repeated contact
Eye Damage/Irritation: Mild transitory irritation
Respiratory Effects: Inhalation of large amounts of powder may cause mild respiratory irritation
Carcinogenicity: No data indicating carcinogenic effects in humans or animals
Mutagenicity: No mutagenic effects detected in industry or regulatory tests
Other Chronic Effects: Not expected under normal conditions of use and handling
Ecotoxicity: Expected low toxicity for aquatic or terrestrial organisms
Persistence and Degradability: Readily biodegradable in the environment
Bioaccumulative Potential: Not expected to bioaccumulate due to low Kow and molecular size
Mobility in Soil: Moderate mobility, water soluble fraction moves with groundwater
Other Adverse Effects: No known significant environmental hazards at expected concentrations
Waste Treatment Methods: Dispose of as non-hazardous organic waste through licensed waste disposal contractor
Recommended Disposal: Incineration or landfill in compliance with local, regional, national, and international regulations
Contaminated Packaging: Triple rinse containers before recycling or disposal; dispose of rinsate as chemical waste
Spillage Disposal: Collect powder, sweep or vacuum, and transfer to appropriate waste containers
UN Number: Not regulated for transport
UN Proper Shipping Name: Not applicable
Transport Hazard Class: Not classified
Packing Group: Not assigned
Marine Pollutant: No
Special Precautions: Basic accident prevention principles apply, avoid spillage during transport
International Inventories: Included in most major chemical inventories
OSHA Status: Not hazardous
SARA Title III: Not listed, no reportable quantities
FDA Status: Approved for use as a flavor enhancer and sweetener in food products
EU Regulations: Permitted food additive, assigned E number E959
Labeling Requirements: No specific hazard pictogram required
Other Local, National, or International Regulations: Check relevant regulations and standards in end-use country for registration and permissible applications
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
