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Product Name: Neohesperidin Dihydrochalcone
Chemical Formula: C28H36O15
CAS Number: 20702-77-6
Molecular Weight: 612.58 g/mol
Synonyms: NHDC, Neohesperidin DC
Recommended Use: Artificial sweetener, flavor modifier
Supplier Details: Available from major suppliers in food additives or chemical industries
Contact Information: Emergency contact provided by manufacturer or supplier, including telephone and email
Product Description: Fine white to off-white powder, sweet-tasting, used mainly in food industry
Intended Users: Industrial food producers, research laboratories, specialty food developers
Classification: Not classified as hazardous under GHS criteria
Human Health Hazards: May cause mild irritation if inhaled, ingested, or in direct contact with skin and eyes; prolonged exposure can aggravate pre-existing conditions
Label Elements: No symbol or signal word required for regular handling in recommended amounts
Symptoms of Exposure: Coughing, sneezing, mild eye or skin discomfort
Risk of Chronic Exposure: Currently, no evidence for carcinogenic, mutagenic, or reproductive toxicity effects reported in credible studies
Precautionary Statements: Avoid generation of dust and direct inhalation; practice proper hand hygiene after use
Environmental Hazards: Not expected to present significant hazards to aquatic or terrestrial life based on low persistence
Chemical Name: Neohesperidin Dihydrochalcone
Content: More than 98% by weight
Impurities: Trace amounts of related flavonoid compounds possible, typically below 1%
Additives: None unless specified by supplier, primarily supplied pure for formulation and blending
Molecular Structure: Derivative of neohesperidin from bitter orange, hydrogenated to dihydrochalcone form
Ingredient Origin: Synthetic process from natural citrus sources or commercial synthesis pathways
Inhalation: Move affected person to fresh air, seek medical advice if respiratory irritation persists
Skin Contact: Wash exposed area with soap and plenty of water, remove contaminated clothing; medical attention if irritation remains
Eye Contact: Rinse eyes carefully under running water for at least 15 minutes while holding eyelids open; seek medical attention if symptoms continue
Ingestion: Rinse mouth thoroughly, drink water to dilute; medical attention if large quantities swallowed or symptoms develop
Emergency Support: Supportive treatment and symptomatic care, no known antidote
Note for Physicians: Symptoms are expected to be mild, no specific medical intervention widely established
Suitable Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide
Unsuitable Extinguishing Media: Avoid high-pressure water streams which could spread dust
Special Hazards: Combustible dust may form explosive mixtures with air in rare conditions; standard precautions for organic dust fires
Hazardous Combustion Products: Releases oxides of carbon during combustion
Protective Equipment: Firefighters should use self-contained breathing apparatus and protective gear
Fire Response Advice: Remove product from fire area if safe to do so, use measures to control dust dispersion
Personal Precautions: Wear dust mask, gloves, and goggles to prevent inhalation and contact; avoid creating airborne dust
Environmental Precautions: Prevent large spills from entering waterways or soil by using barriers or spill kits
Spill Cleanup Methods: Sweep up material carefully, minimize dust formation, collect in a suitable container; wash affected area with water
Waste Disposal: Dispose according to local regulations for non-hazardous organic substances
Reporting: Report significant spills to local authorities as required
Safe Handling Practices: Minimize dust generation, use in well-ventilated spaces, wear personal protective equipment as standard
Storage Requirements: Store in tightly closed containers, in cool, dry, well-ventilated area away from incompatible materials such as strong oxidizers
Temperature Sensitivity: Store below 25°C for best shelf life
Incompatibilities: Strong acids, bases, oxidizing agents
Hygiene Measures: Wash hands before eating, drinking, or smoking after handling material
Additional Protection: No eating or drinking in storage or handling area to avoid accidental ingestion
Exposure Limits: Occupational exposure limits not established for NHDC; limit dust exposure using good industrial hygiene practice
Engineering Controls: Local exhaust ventilation recommended where dusts are generated
Personal Protective Equipment: Gloves, dust mask (N95 or equivalent), protective goggles for eye safety, lab coat or coveralls for skin protection
Respiratory Protection: Use particulate respirator if workplace conditions suggest dust every day
Eye/Face Protection: Chemical splash goggles or safety glasses with side shields
Skin Protection: Nitrile or latex gloves recommended for frequent handling
Monitoring of Airborne Dust: Periodic checks using appropriate workplace sampling techniques
Appearance: White to off-white crystalline powder
Odor: Odorless or slightly sweet
pH (1% Solution): 5.0 to 7.0
Melting Point: 156-158°C (decomposes)
Solubility: Soluble in water, slightly soluble in ethanol
Vapor Pressure: Not applicable (non-volatile solid)
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not established, organic dust can combust under select conditions
Flammability: Not highly flammable, but may contribute to dust explosion risk in confined zones
Density: Approx. 1.5 g/cm³
Partition Coefficient (log Kow): Not readily available
Auto-Ignition Temperature: Not precisely established, avoid contact with flames or hot surfaces
Chemical Stability: Stable under recommended storage and handling conditions
Thermal Decomposition: Decomposes above 155°C with release of organic vapors
Reactivity: Non-corrosive, does not react with common container materials
Conditions to Avoid: Excessive heat, open flames, contact with strong oxidizers, sources of ignition
Hazardous Reactions: No dangerous reactions expected with normal use
Hazardous Decomposition Products: Forms carbon monoxide, carbon dioxide, small amounts of other organic gases on severe heating
Acute Toxicity: Low toxicity by oral, dermal, and inhalation routes based on available animal studies
LD50 (Oral, Mouse): Greater than 3,000 mg/kg
Skin Irritation: May cause mild irritation on prolonged contact with sensitive skin
Eye Irritation: Dust can cause temporary discomfort or redness
Respiratory Sensitization: Prolonged exposure to dust may aggravate asthma or existing lung issues
Chronic Effects: No evidence of long-term toxicity, carcinogenicity, or reproductive toxicity in scientific reviews
Medical Conditions Aggravated: Existing allergies, eczema, or respiratory conditions
Other Information: No evidence for mutagenicity or teratogenicity in qualified studies
Aquatic Toxicity: Low predicted toxicity to fish and aquatic organisms based on structure and lack of bioaccumulation
Persistence and Degradability: Biodegradable in soil and water by standard microbial pathways
Bioaccumulative Potential: Not expected to bioaccumulate, low mobility in soil
Mobility in Soil: Moderately mobile, can leach with excessive water but breaks down readily
Other Adverse Effects: Not expected to disrupt sewage treatment bacteria or contribute to long-term environmental damage
Data Source: Results based on read-across from closely related citrus flavonoids and sweeteners
Product Disposal: Handle as non-hazardous solid waste unless contaminated with dangerous substances; best practice is incineration or regular landfill according to local laws
Container Disposal: Triple rinse containers before recycling or disposal; follow supplier guidance if supplied in bulk
Regulations: Comply with state and local waste management laws
Precautions: Minimize dust generation during disposal, avoid uncontrolled release into drains or surface water
UN Number: Not regulated for transport
Proper Shipping Name: Not classified as dangerous goods
Hazard Class: No special class required under ADR, IMDG, or IATA
Packing Group: No packing group assigned
Special Precautions: Handle with care to prevent damage to packaging and control dust; avoid moisture ingress
Label Requirements: No labels required under global transport regulations
International Inventories: Listed on US TSCA, EU EINECS/ELINCS, Japan ENCS, Australia AICS, and other major chemical inventories
Safety Regulations: No OSHA hazard classification in the United States; not listed as a Proposition 65 chemical in California
Labeling Requirements: No specific GHS labeling required under European or US guidelines for food-grade product
Food Additive Approvals: Permitted additive in EU (E-959), accepted in several countries for use at designated levels in beverages and food products
Worker Protection Standards: Follows general food ingredient handling rules; routine use of gloves, eye protection, and dust controls
Community Right-To-Know: Disclosure requirements depend on jurisdiction; generally not subject to strict emergency planning or reporting under SARA Title III or similar
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
