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Product Name: Natamycin
Synonyms: Pimaricin, E235
CAS Number: 7681-93-8
Recommended Use: Antifungal agent, food preservative
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GHS Classification: Not classified as hazardous under GHS criteria.
Health Hazards: May cause allergic reactions for sensitive individuals, may irritate eyes, respiratory tract, and skin.
Environmental Hazards: Not expected to pose significant threat in standard quantities, but persistent in some environments.
Signal Word: None
Pictogram: None required
Hazard Statements: Possible irritant to eyes, skin, and respiratory system.
Precautionary Statements: Avoid inhalation and contact with eyes or skin; use personal protective equipment as necessary.
Chemical Name: Natamycin
Concentration: Typically supplied as pure or in mixtures; specific concentration to be confirmed by supplier.
Other Components: Some preparations mix natamycin with dextrin or glucose for stability.
Molecular Formula: C33H47NO13
Molecular Weight: 665.73 g/mol
Inhalation: Move affected person to fresh air immediately. Seek medical attention if breathing becomes difficult.
Eye Contact: Rinse repeatedly with water for at least 15 minutes, keeping eyelids open. Remove contact lenses after initial 1-2 minutes and continue rinsing.
Skin Contact: Wash area with soap and water for several minutes. Remove contaminated clothing and wash before reuse.
Ingestion: Do not induce vomiting without medical advice. Rinse mouth with water and get medical attention if large quantities were swallowed or symptoms develop.
Symptoms: Irritation, redness, allergic reaction in sensitive individuals, cough or difficulties in breathing in case of large exposure.
Recommendations: Medical assistance recommended for persistent symptoms or concerns.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, water spray, foam.
Unsuitable Extinguishing Media: Strong direct jet of water can spread powder.
Specific Hazards: Burning may release carbon oxides and irritating vapors such as nitrogen oxides.
Protection for Firefighters: Use self-contained breathing apparatus and full firefighting gear to prevent inhalation of dust and fumes.
Thermal Decomposition: Toxic fumes possible.
Personal Precautions: Wear protective gloves, dust mask, goggles. Avoid breathing dust. Ensure adequate ventilation.
Environmental Precautions: Prevent product from entering drains, water sources, or soil. Contain spill.
Methods for Clean-Up: Sweep up and collect in suitable sealed container. Minimize dust formation. Wash spill site with water after material pickup.
Waste Disposal: Dispose in accordance with local, regional, and national regulations.
Handling Precautions: Avoid contact with eyes, skin, and clothing. Prevent formation of dust clouds. Do not ingest or inhale. Use only in well-ventilated areas.
Hygiene Measures: Wash hands, forearms, and face thoroughly after handling. Remove contaminated clothing; wash before reuse.
Storage Conditions: Store tightly closed in a dry, cool, and well-ventilated place. Keep containers away from direct sunlight, heat sources, and moisture.
Incompatible Materials: Strong oxidizing agents.
Shelf Life: Check manufacturer's guidelines for specific stability, usually stable under recommended conditions.
Exposure Limits: No specific occupational exposure limits established.
Engineering Controls: Use with local exhaust ventilation or in chemical fume hood to minimize release of dust.
Personal Protective Equipment:
Appearance: White to off-white, fine crystalline powder
Odor: Nearly odorless
Odor Threshold: Not determined
pH: Neutral in aqueous solution, approx. 5–7
Melting Point: Decomposes on heating above 170°C
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not determined
Evaporation Rate: Not applicable
Flammability: Not readily combustible
Vapor Pressure: Not applicable
Solubility: Poorly soluble in water; soluble in methanol and DMSO
Partition Coefficient: Not available
Auto-Ignition Temperature: Not determined
Decomposition Temperature: >170°C
Viscosity: Not applicable
Chemical Stability: Stable at room temperature under recommended conditions.
Conditions to Avoid: Excess heat, exposure to moisture, light, strong oxidizing agents.
Reactivity: No hazardous reactions expected under normal use.
Materials to Avoid: Strong acids, strong bases, strong oxidizers.
Hazardous Decomposition Products: Under fire or extreme heat, toxic gases and vapors may form, including carbon oxides and nitrogen oxides.
Acute Toxicity: Oral LD50 in rats estimated > 2,000 mg/kg (low toxicity).
Chronic Toxicity: No evidence for carcinogenicity, mutagenicity, or reproductive toxicity in animal models at prescribed levels.
Routes of Exposure: Inhalation, ingestion, skin and eye contact.
Symptoms and Effects: May cause minor irritation of eyes, skin, respiratory tract; reports of allergic reactions in rare cases.
Sensitization: Prolonged contact may cause allergic response in susceptible individuals.
Additional Information: Not listed as a carcinogen by IARC, NTP, or OSHA.
Ecotoxicity: Exhibits antifungal activity, potential risk to aquatic and soil fungi at elevated concentrations.
Persistence and Degradability: Stable in soil and may persist for days to weeks, depending on environmental factors.
Bioaccumulation Potential: Low probability of bioaccumulation in aquatic organisms.
Mobility in Soil: Low water solubility limits leaching potential.
Other Adverse Effects: No observed effects on fish and aquatic invertebrates in available studies. Avoid uncontrolled environmental release.
Disposal Methods: Dispose as chemical waste in accordance with national and local regulations. Avoid disposal into waterways or sewer systems.
Container Disposal: Empty containers should be rinsed and discarded per guidelines; avoid reuse for other chemicals.
Precautions: Wear appropriate protective equipment when handling residues; avoid formation of airborne dust.
Environmental Notes: Prevent release to environment during disposal procedures.
UN Number: Not classified as hazardous for transport.
UN Proper Shipping Name: Not regulated.
Transport Hazard Class: Not applicable.
Packing Group: Not applicable.
Environmental Hazards: Not considered a marine pollutant.
Special Precautions: Avoid packaging with foodstuffs and oxidizing agents. Protect containers from physical damage and shifting.
Transport in Bulk: Not regulated.
Regulatory Status: Approved worldwide as food additive E235; subject to specific limits in food products by regulatory bodies such as FDA (US), EFSA (EU), FAO/WHO (Codex Alimentarius).
Chemical Inventory Listings: Included in major chemical inventories such as TSCA (US), EINECS (EU), DSL (Canada).
Labeling Requirements: No hazard labeling required as per GHS for standard quantities.
Restrictions: Set limits for foods depending on local regulation (typically 1–20 mg/kg for surface treatment of cheese, sausages, baked goods).
Other Requirements: Workers handling large quantities must be trained in chemical safety. Local and national authorities may require spill reporting and safe disposal documentation.
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
