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Product Name: Moxidectin
Chemical Name: 23-(O-methyloxime)-B1
CAS Number: 113507-06-5
Synonyms: Cydectin, Quest, ProHeart
Recommended Use: Veterinary antiparasitic agent
Manufacturer: Leading veterinary pharmaceutical firms
Emergency Phone: Refer to local poison control resources for immediate assistance
Address: Refer to the product label or manufacturer documentation for physical location details
Classification: Acute Toxicity Oral (Category 4), Eye Irritation (Category 2), Aquatic Chronic Hazard (Category 1)
GHS Label Elements: Signal word: Warning; Hazard pictograms: Exclamation mark, Environment; Hazard statements: Harmful if swallowed, causes serious eye irritation, very toxic to aquatic life with long lasting effects
Routes of Exposure: Ingestion, eye contact, skin contact, inhalation
Pictogram Meaning: Environmental toxicity, risk to aquatic organisms; signal for both acute health risk and environmental hazard
Potential Health Effects: May cause discomfort or irritation to eyes, skin, respiratory tract; accidental ingestion can lead to neurological effects in mammals
Precautionary Statements: Avoid release to the environment, wash hands thoroughly after handling, use personal protective equipment
Chemical Component: Active Ingredient: Moxidectin
Concentration: 90–98% (purity varies by supplier)
Other Ingredients: Inactive ingredients may include propylene glycol, emulsifying agents, stabilizers, and solvents, type and proportion vary depending on the formulation
Impurities: May contain trace levels of process solvents or related macrocyclic lactone compounds
Molecular Formula: C37H53NO8
Molecular Weight: 639.8 g/mol
Eye Contact: Rinse with cold water for several minutes, remove contact lenses, continue irrigation, seek medical attention if symptoms persist
Skin Contact: Wash affected area with soap and water, remove contaminated clothing and shoes, seek medical guidance if irritation develops
Ingestion: Do not induce vomiting, rinse mouth with water, call poison control or healthcare provider immediately
Inhalation: Relocate victim to fresh air, keep at rest and warm, obtain medical advice if effects occur or persist
Advice for Medical Personnel: Provide symptomatic treatment, monitor vital signs, and treat any allergic or neurological symptoms as observed
Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide
Special Hazards: Product can decompose under fire conditions to form hazardous vapors including carbon oxides, nitrogen oxides, and potentially toxic organic compounds
Protective Equipment: Firefighters need self-contained breathing apparatus and full protective gear to avoid inhalation or skin contact
Firefighting Techniques: Isolate area, prevent runoff from entering water sources, cool unaffected containers with water spray to prevent rupture
Combustion Products: Smoke, carbon monoxide, carbon dioxide, nitrogen compounds
Personal Precautions: Evacuate unprotected personnel, ensure proper ventilation, use appropriate personal protection (gloves, goggles, mask)
Environmental Precautions: Prevent release into soil, surface water, or municipal sewers, contain spill with absorbent materials
Clean-up Methods: Absorb spill with earth, sand, or non-combustible material, collect residue into containers for proper disposal, wash area with bleach solution or detergent
Disposal: Dispose of according to local regulations for hazardous waste
Reporting: Inform authorities if a significant quantity enters waterways or public lands
Handling: Wear protective gloves, avoid contact with eyes, skin, and clothing, prevent accumulation of dust or aerosol, avoid sources of ignition
Storage: Store in cool, dry, well-ventilated space, away from incompatible materials such as strong oxidizers, acids, and bases, keep container tightly closed
Special Instructions: Segregate from animal feeds and foodstuffs, label containers clearly, use only as directed for veterinary applications
Incompatibilities: Strong acids, strong bases, oxidizing agents
Exposure Limits: No established occupational exposure limits; minimize exposure as a prudent measure
Engineering Controls: Local exhaust ventilation, process enclosure, eye wash stations in working area
Personal Protective Equipment: Chemical-resistant gloves, laboratory coats, splash-proof goggles or face shield, respirator if dust or aerosols may be generated
Hygiene Measures: Wash hands before eating or smoking, avoid direct contact, do not eat or drink in work area, launder contaminated clothing before reuse
Physical State: Solid or viscous oil, depending on specific formulation
Color: White to off-white
Odor: Nearly odorless
Odor Threshold: Not determined
pH: Not applicable
Melting Point: 62–64°C
Boiling Point: Decomposes before boiling
Flash Point: >110°C (closed cup, for technical material)
Solubility: Practically insoluble in water, soluble in organic solvents (methanol, ethanol, acetone, chloroform)
Vapor Pressure: Very low at 25°C
Density: 1.15 g/cm³ (approximate)
Stability: Stable under recommended storage conditions
Reactiveness: Can react with strong oxidizing agents, acids, or bases
Hazardous Reactions: No dangerous reactions known under normal conditions
Decomposition Products: May produce hazardous gases or fumes during thermal decomposition; carbon oxides, nitrogen oxides
Polymerization: Not known to occur
Acute Toxicity (Oral): LD50 (rat): 86 mg/kg; harmful if swallowed
Dermal Toxicity: LD50 (rat): >2000 mg/kg; low toxicity by skin contact
Inhalation Toxicity: Data limited for inhalation route, treat dusts and aerosols as harmful
Skin Corrosion/Irritation: May cause mild skin irritation
Eye Damage/Irritation: Causes eye irritation, redness, or discomfort
Chronic Effects: Evidence of neurotoxic effects at high doses; no strong evidence for carcinogenicity, mutagenicity, or reproductive toxicity in mammals with recommended exposure
Sensitization: Not classified as a skin sensitizer based on animal data
Ecotoxicity: Extremely toxic to aquatic invertebrates and fish; LC50 for Daphnia magna < 2 µg/L
Persistence and Degradability: Moderately persistent in soil and water; susceptible to slow biodegradation by sunlight and microbes
Bioaccumulative Potential: Likely to bioaccumulate in aquatic organisms, high partition coefficient (Log Kow 5.7)
Mobility: Low water solubility, strongly adsorbed to soils and sediments, minimal mobility in terrestrial systems
Other Adverse Effects: Potential for long-term adverse effects in aquatic environments and for secondary poisoning of predators eating contaminated prey
Waste Disposal Methods: Incinerate in a chemical incinerator equipped with afterburner and scrubber, or dispose as hazardous waste according to local, state, and federal regulations
Packaging Disposal: Rinse containers thoroughly, puncture or crush, do not reuse for any other purpose, send for landfill or incineration as regulated waste
Precautions: Avoid environmental contamination, do not discharge to surface waters or sewage systems, consult authorities for specific guidance
Handling Spills During Disposal: Minimize dust, wear protective equipment, recover product for proper disposal
UN Number: 3077
UN Proper Shipping Name: Environmentally Hazardous Substance, Solid, N.O.S. (Moxidectin)
Transport Hazard Class: 9 (Miscellaneous dangerous substances and articles)
Packing Group: III
Environmental Hazards: Marine pollutant
Special Precautions: Handle to avoid release to environment, ensure packaging integrity, follow all labeling and documentation requirements
Transport Regulations: Comply with ADR/RID, IMDG, ICAO/IATA regulations for safe passage
Safety, Health, and Environmental Regulations: Moxidectin falls under veterinary drug controls and is listed on various chemical inventories globally
OSHA Status: Not specifically regulated, general chemical safety applies
EPA Status: Subject to FIFRA pesticide review in the United States; designated as hazardous to aquatic environments
Other Applicable Legislation: REACH (Europe) registration required for manufacturers and importers; controlled in Australia, Canada, Japan by respective veterinary and environmental agencies
Warning Phrases: Harmful if swallowed, dangerous for the environment, keep out of reach of children, use only as instructed
Labeling Requirements: Product label must indicate hazard symbols, precautionary statements, and emergency contact
