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Monascus Red: A Deep Dive into a Storied Ingredient

Historical Development

People in East Asia found out centuries ago that cultivating Monascus purpureus on rice created a rich, red material with special properties. Long before food colorants came out of labs, fermented red yeast rice let Chinese cooks add vibrant color and a touch of earthy, umami flavor to all kinds of dishes. Monascus Red played a role in medicine, too; old records from the Ming dynasty mention its use in helping digestion and circulation. Japan and Korea also took up the practice, with rice wines and fermented pastes tinted scarlet with this humble microbe. Over time, Monascus Red made the jump from backroom fermenters to factories, keeping its hold as both a coloring agent and a symbol of tradition. Even in industrial settings, knowledge rooted in history guides how producers coax the deepest color out of the organism.

Product Overview

Monascus Red stems from the fungal fermentation of grains, usually rice. At the end of a slow, controlled process, you get a red pigment that stands up well in cooking. Food manufacturers use it to color liquor, vinegar, bean curd, pastries, and more. Compared with the harsh reds of synthetic dyes, Monascus Red brings a subtle warmth and a certain complexity to food—it matters to cooks who chase both beautiful color and honest flavor. Unlike substances made in chemical plants, the Monascus pigments arise from natural metabolic pathways, and that old-world origin matters to many consumers worried about artificial additives.

Physical & Chemical Properties

Monascus Red comes out as a fine powder or concentrated liquid, with hues ranging from deep crimson to purple depending on conditions. Its main characteristics—solubility in water and alcohol, stability under moderate heat, sensitivity to strongly acidic or alkaline environments—shape where it makes sense to put this pigment. The core coloring compounds, monascorubrin and rubropunctatin, are polyketide pigments locked inside the fungal matrix. Once separated and purified, these compounds behave predictably under ordinary cooking, but break down if exposed to bleach or strong acids. Anyone who’s worked with Monascus derivatives has seen pigments fade if left in sunlight or mixed with the wrong preservatives.

Technical Specifications & Labeling

Regulators across multiple countries keep a close eye on details like moisture content, pigment concentration, ash levels, and possible toxic byproducts in Monascus Red extracts. Product specifications usually demand a certain brightness—often measured in absorbance units—along with limits on citrinin, a possible toxin. Labels need to specify “Monascus Red” or “Red yeast rice color,” including batch numbers and best-by dates. I’ve seen thorough batch testing on factory floors, as certifications—often including ISO or local food safety standards—support wider acceptance in export markets.

Preparation Method

Making Monascus Red in a traditional way starts by soaking rice, then cooking it to the right texture. Spores of Monascus purpureus mix into the cooled rice, and the whole batch rests at the right temperature to let the fungus grow. Over a few days, red blooms spread across each grain. Once fermentation ends, drying and milling separate pigment from the rice base. Modern production lines scale this up, controlling every detail—humidity, temperature, oxygen levels—using stainless-steel fermenters and automated dryers. Downstream purification techniques (solvent extraction, membrane filtration) strip out impurities and concentrate the color. I’ve seen labs run hundreds of tiny fermentations, fine-tuning each variable to hit customer specs.

Chemical Reactions & Modifications

Monascus pigments go through complex reactions right inside the rice during fermentation. Fungal enzymes help shape and alter the chemical rings that give the color its intensity. Later, adjustments—including shifting pH or mixing in stabilizing agents—keep the pigment durable. Chemical modifications through esterification or glycosylation sometimes change solubility or shift the color toward orange or purple, suiting specific applications in foods and drinks. Research outfits dive into producing Monascus analogs with fewer toxins and more stable color, so there’s plenty of science left to master these pigments.

Synonyms & Product Names

Walk through a food additives warehouse and you’ll find Monascus Red listed under names like “Red Yeast Rice Color,” “Natural Red 9,” “Monascus Pigment,” or the trade-marked versions created by big players in the market. Catalogues use E numbers (E175) in some jurisdictions, and food researchers sometimes refer to pigment fractions by their chemical composition—monascin, ankaflavin, rubropunctamine. The legacy names hint at how global and varied the usage has become.

Safety & Operational Standards

Safety concerns center around byproducts like citrinin, which can crop up if fermentation goes wrong. Food producers measure citrinin levels closely because it brings risks to kidney health if allowed above certain ppb (parts-per-billion) limits. Keeping production safe means choosing the right fungal strains, careful monitoring of fermentation, and frequent spot-checks for mycotoxins. Operators in plants need good ventilation, skin protection, cleaning protocols, and training on dust minimization. Countries differ on what they permit; China and Japan have long approved Monascus Red, while the European Union and U.S. draw sharper lines between culinary and supplement uses.

Application Area

Most Monascus Red finds its way into food, especially in the coloring of pickled radish, rice wine (like Chinese huangjiu), fermented bean curd, and a parade of Asian pastries. Brewers reach for it to achieve a distinctive ruby color in sake or mead. Some bakers use it to tint bread, noodles, and vegan cheese. The supplement market also uses red yeast rice capsules for claims around cholesterol, though regulators fret about unapproved statin-like side compounds. I’ve even seen specialty cheese and salami producers in Europe testing Monascus pigments as a more natural alternative to nitrites and carmine. The potential goes beyond food today—cosmetics and textiles benefit from Monascus-based reds, chasing clean-label ingredients.

Research & Development

Research labs dig into the genetics of Monascus species, looking to breed strains that make more pigment or less citrinin. Scientists work on fermentation control, searching for combinations of grains, temperature, and culture time that spike just the right color range. Analytical chemists track every compound using HPLC and mass spectrometry—if a batch shifts color, they know exactly which molecule caused it. Companies fund work on encapsulation and stabilization, hoping to broaden the range of end uses. Some researchers focus on bioactivity, probing whether any Monascus compounds actually help with blood pressure or inflammation.

Toxicity Research

The citrinin question looms over Monascus Red. Animal studies show that citrinin impacts kidney health, so food laws demand near-zero levels in finished products. The chemical is tough to remove completely, which sparks ongoing research into “clean” strains or processing steps that exclude dangerous byproducts. Some studies check whether Monascus pigment itself interacts with DNA or cells in unexpected ways—so far, except for the citrinin issue, the pigment looks benign in usual food amounts. European researchers run long-term feeding studies in rodents and cell lines just to be sure. Producers test every production batch, since regulators in the EU or U.S. will ban imports immediately if unsafe levels turn up.

Future Prospects

More chefs and food producers want natural colors today, so interest in Monascus Red only grows. Researchers keep working to engineer smart fungal strains that maximize pigment while dropping risk. Bioreactor fermentations—once a trick for pharmaceuticals—now play a bigger role in pigment production. Governments might soon align standards and labeling, making global trade easier. I see a likely future where Monascus Red joins a suite of natural colorants certified for safe, consistent use across the world, both in food and in wellness products. The story of Monascus Red keeps evolving, shaped by a mix of tradition, science, and the push for safer, more authentic food ingredients.




What is Monascus Red and how is it produced?

From Ancient Fermentation to Modern Ingredients

Monascus red comes from a tiny mold, Monascus purpureus, that grows on steamed rice. Across China and parts of Southeast Asia, people have been using monascus for hundreds of years to make rice wines, fermented bean curd, cured meats, and even as a natural food color. My grandmother would drop a handful of this crimson rice into her soup pot or dumpling mix and expect a richer hue, not just a new taste. Seeing her bright red meats at family dinners drove home how food and culture become inseparable.

Making It: Fermentation in Action

The process starts by mixing rice with water and sometimes yeast nutrients, then sterilizing the batch. After cooling, folks scatter the monascus mold spores across the rice, making sure everything stays moist and warm—usually in a dark spot. This setup needs looking after. If too dry or cold, the mold stops working. Too hot, and everything sours or spoils. After a few days, the rice turns cherry red and develops a tangy smell.

For industries, things get much more controlled. Stainless steel tanks, filtered air, strict checks against unwanted bacteria—all of these keep the product consistent and safe. After fermenting, workers extract the red pigment using alcohol or water, then purify it so it meets food safety rules. Some companies add extra steps to fine-tune pigment strength or take out certain byproducts.

Functional Food, Not Just a Color

Monascus rice isn’t just for visual appeal. The fermentation makes compounds called monacolins, especially monacolin K—known for lowering cholesterol. In many Asian kitchens, that functional benefit is old news. Science caught up, and labs confirmed links to improved blood lipid profiles. However, not all monascus products contain helpful levels, and some batch variations might even create citrinin, a toxic byproduct.

Food safety authorities like the European Food Safety Authority and FDA set limits on citrinin to protect public health. Modern production uses improved strains that cut down on citrinin and regular quality checks help. Consumers can look for certifications and lab reports to be sure they’re getting safe products.

Why Bother With Natural Colors?

People voice concerns about synthetic food dyes due to possible health risks or allergies. Natural pigments from monascus don’t just look nice; they connect meals with ancient customs and offer dietary benefits. Like most traditional foods, moderation remains essential. Overconsumption, or using unverified substances, brings more risk than reward.

In Japan, Korea, and China, attention to quality runs high. Producers often run small batches, know their sources, and keep production close to the community. In commercial settings, full traceability means shoppers can follow the that red rice back to its origins.

The future of monascus red looks promising. Ongoing research aims for safer fermentation processes and methods that maximize healthful compounds while blocking toxins. By learning from tradition and staying rooted in evidence, both home cooks and big manufacturers find ways to keep this classic hue gracing dinner tables without sacrificing safety or trust.

Is Monascus Red safe for consumption?

A Closer Look at Monascus Red

Monascus red shows up in a surprising number of foods you find at Asian grocery stores. You see the vivid red in rice wines, fermented bean curd, sausages, and even mooncakes. It owes its color to Monascus purpureus, a fungus that’s been part of Chinese cooking for centuries. The color draws attention, but plenty of folks wonder about its safety.

What We Know From Science and Tradition

Monascus red has a solid track record. Generations in East and Southeast Asia eat foods colored or fermented with this pigment with no major health alarms. The microbes involved break down rice, and that fermentation leaves behind a red pigment and complex flavors. The method hasn’t changed much since the days of Emperor Wu of Han, more than 2,000 years ago.

There’s a catch, though. Monascus red made at home or with traditional recipes often contains natural byproducts. The main one that gets experts worried is citrinin. This compound can cause kidney issues, at least in animal studies. Plenty of modern producers understand the risks and have invested in citrinin-free strains. Countries like China and Japan use strict testing to keep commercially sold products within safe limits.

Is Regulation Enough?

The rules on monascus red change across the globe. China lists it on their approved food additive list, but only after checking for toxins like citrinin. The European Union pulls back and doesn’t authorize Monascus red as a food color. The United States considers red yeast rice as a supplement and only endorses it if it doesn’t include lovastatin, a cholesterol-lowering compound also made by the mold.

All food regulatory agencies set tolerances for unsafe byproducts. The problem? Small manufacturers and imported products sometimes fall outside those checks. Every time I see a scarlet-hued bottle of rice wine from a lesser-known brand, I find myself squinting at the label and wondering about the standards behind it. Trust in the brand and country of origin counts for a lot.

Weighing the Risks and Benefits

Monascus red stands out from synthetic colors by adding not just hue, but taste and aroma. Some studies highlight potential benefits like blood lipid regulation or antioxidant effects, thanks to the mix of natural compounds made during fermentation. This doesn’t mean more is better. Taking Monascus-based supplements for cholesterol, for example, may expose people to side effects and unintentional drug-like doses.

What Consumers Can Do

Looking for quality marks and country-of-origin details helps reduce risk. Registered products in major supermarkets usually follow rules for toxin levels. If you prefer supplement forms for cholesterol management, ask about third-party lab results and avoid mystery pills. Cultural foods made with Monascus red, eaten now and then as part of regular meals, fit into a balanced life with few issues.

New research on breeding citrinin-free strains and improving production is underway. As food science gets better at keeping fermentation safe, folks won’t have to choose between tradition and health. Until then, a little bit of skepticism and label-reading goes a long way.

What are the main uses of Monascus Red in food products?

Bringing Color to Everyday Foods

People eat with their eyes. Color changes the way food looks and even the way it tastes in our minds. Monascus Red, or red yeast rice pigment, does this job in a big way for many cultures, especially across Asia. It’s more than just a colorant—it brings tradition to the table. Walk through a Chinese supermarket and you’ll see its effect in red-tinted sausages, vinegars, and spirits. It gives a deep, natural red that screams “festive” to anyone raised on Lunar New Year dishes.

Traditional Flavors, Modern Demand

Monascus Red came into my life at family gatherings. My grandparents insisted that red-cooked meats only looked right with its special hue. It’s not just about the look, either. There’s a touch of earthy depth that the pigment brings, especially when used in old-school recipes for rice wine, barbecued pork, or even tofu. These foods look richer and stand out against the endless rows of supermarket options pumped full of artificial coloring. Monascus Red, coming from natural fermentation, helps food makers meet the craving for things that feel less processed, more like what our grandparents trust.

Health and Perception

It’s easy to forget, but color in food carries a health story. Many shoppers these days dig through ingredient lists for things they recognize. Artificial colors—often with strings of numbers and chemical names—make them nervous. Monascus Red lets producers swap those out for something that’s been in use for more than a thousand years. Science backs up its safety, though not every country gives it a clear pass. In China, it’s a kitchen staple, but in the US and Europe, regulators demand a closer look. Research shows that Monascus Red pigments break down safely in the body, and careful manufacturing can keep out some of the naturally occurring byproducts people worry about, like citrinin.

Pushing for Cleaner Labels

Shoppers want food labels they don’t have to Google. Monascus Red lines up with this push for “clean labels.” Food makers get a bold, warm red without resorting to chemicals that have faced health concerns. The trend goes double for meat alternatives, plant-based proteins, and products aiming to look and taste “real.” Adding Monascus Red to vegan deli slices or mock duck not only makes them Instagram-friendly but also connects with consumers tired of long ingredient lists. They see fewer artificial names, and studies show this boosts both trust and sales.

Looking at the Challenges

No additive is perfect, and Monascus Red has its quirks. The coloring is sensitive to light and temperature. Packaged foods can lose brightness if they sit on shelves too long. Not every company invests in the best storage and preparation methods, so you’ll spot inconsistency from brand to brand. Another challenge is guaranteeing purity—fungal fermentation can produce unwanted compounds if not controlled carefully. Leading producers rely on strict quality control and transparent sourcing to set themselves apart.

What’s Ahead?

Monascus Red shows its value at every stage, from home kitchens to massive factories. More brands give it a shot as people look for simple, recognizable ingredients in the foods they trust. Health-conscious shoppers and traditional cooks cross paths, both finding something familiar in the same reddish hue. Where my own family sees a reminder of holidays, science brings reassurance that today’s Monascus Red is safer, more consistent, and easier to trust than ever. The question now is which markets will catch up next—and if regulators see its roots the same way everyday people do.

Are there any side effects or health risks associated with Monascus Red?

Monascus Red in the Food World

Monascus Red, pulled from the fermentation of Monascus purpureus, brings a bold pop of color to Chinese sausages, fermented bean curd, rice wine, and more. It holds a spot in kitchens and factories, trumpeted for being “natural” — a word that still catches shoppers’ eyes on food labels. Not everyone stops to think about safety, probably because it’s been around for centuries.

Diving Into Side Effects: What Science Tells Us

Natural doesn’t always equal harmless. Backed by industry experience and research, Monascus Red’s main risk comes down to citrinin, a mycotoxin that sometimes forms during fermentation. Long-term or high-dose exposure to citrinin links to kidney damage in animal studies and can put a person’s health at risk if levels slip through regulation cracks. The European Food Safety Authority drew a line at 200 μg/kg for citrinin, and China’s standards sit close at 50 μg/kg.

Back in 2016, Chinese researchers tested batches of Monascus Red used in the market and uncovered some samples that snuck above that safety line. Without strict controls, it’s easy for a bad batch to reach the table. People with kidney trouble or fragile immune systems might feel the hit harder and face bigger risks with regular exposure.

Gaps in Regulation and Transparency

Strict oversight can keep these products safe, but smaller producers might cut steps or costs. Consumer trust drops when companies don’t openly lay out their testing processes or results. Even well-meaning manufacturers struggle, since the amount of citrinin produced can shift depending on the fermentation temperature, strains, and even the nutrients fed into the broth. No single fix fits all situations.

Past my own hospital work, I’ve seen patients admit they never once checked how much processing or safety checks went into the additives in their foods—Monascus Red included. The average person depends fully on food makers to do the right thing. History has shown that this trust doesn’t always end well, especially for vulnerable groups.

Potential Solutions on the Table

Putting health first starts by raising the bar for how Monascus Red gets made, tested, and traced. Clearer labels can help families make smart choices—if a product contains Monascus pigments, it should carry a stamp proving low citrinin levels. Insisting on regular lab testing from third-party labs, not just in-house checks, gives more honest results.

Some biotech labs have already bred Monascus strains that won’t churn out citrinin. Large-scale producers can adopt these strains and share data with regulators, building up trust. Government random spot checks act as backstops to catch any slip-ups. Education also makes a dent—teaching the public how to find and understand food safety certificates and reports.

Many doctors encourage folks with chronic kidney concerns to keep an eye out for fermented products or processed foods, including those using Monascus Red, if they can’t verify safety from known brands or certified sources. People should never feel they have to “just trust” unseen processes, especially with something they eat.

Final Thoughts

No additive or colorant offers perfect safety. The best systems never rely on tradition alone—they track, test, and inform at every step, from the factory to a family dinner. Monascus Red grabs headlines as a natural ingredient, but a truly responsible food industry needs to keep side effects and risks at the front of the conversation.

Is Monascus Red approved by regulatory agencies such as the FDA or EFSA?

Looking at the Popularity

Monascus red comes from fermented rice, stained bright with a unique color by a mold called Monascus purpureus. Across China, Japan, and Southeast Asia, cooks reach for it when they want to color meat, fish, or rice wine. Ancient traditions see Monascus as more than a pigment; some believe it unlocks flavor, and some old records even talk about medicinal benefits. Today’s food industry likes Monascus because it’s considered “natural,” especially when compared against synthetic reds like Allura Red AC or tartrazine.

Regulatory Approval in Focus

Here’s where things get tricky. Food regulatory agencies don’t always agree about which ingredients get to cross national borders and enter commercial kitchens. In the United States, the Food and Drug Administration draws a hard line: Monascus red is not approved as a food additive. Back in the 1980s, researchers flagged that Monascus fermentation can produce citrinin, a mycotoxin linked to kidney damage in both animal studies and some human case reports. Since then, the FDA hasn’t budged. The official list of approved color additives skips right over Monascus; companies can’t use it in packaged foods for the American market.

Europe tells a similar story, despite growing consumer demand for “clean label” colors. The European Food Safety Authority (EFSA) takes a conservative approach as well. Their experts reviewed Monascus and turned it down, also pointing to the risks from citrinin. Some EFSA reports acknowledge the long culinary history in Asia, but history alone doesn’t outweigh present-day food safety standards. So, Monascus red doesn’t show up on the approved list of food colorings that can be used across the EU.

Why Food Safety Arguments Dominate

Regulators don’t act against tradition for no reason. In my own kitchen, it’s easy to look at a bottle of Monascus extract picked up from an Asian grocery and forget about contaminants. But on a mass scale, there’s far less control over what fermentation batches might produce. Current science proves citrinin is a real risk, since it doesn’t take much exposure for kidney cells to show damage. The FDA and EFSA get heavy criticism for being slow, yet anyone who’s worked in food safety understands the pressure. Regulators weigh history and cultural value—but toxicology studies always take top priority.

Exploring Safer Avenues

For companies, the door isn’t completely closed. Some researchers in China and Japan want to breed or engineer Monascus strains that barely produce citrinin. Labs have tried purifying Monascus extracts to keep only the color, leaving out the harmful compounds. But no standardized, foolproof method exists yet, especially for the volumes commercial production demands. The science here feels a little like whack-a-mole: one fix leads to another batch of questions from regulators. So far, the FDA and EFSA hold off until the evidence reaches a level they trust unanimously.

Healthy skepticism and a relentless pursuit of food safety shape these rules. Unless new Monascus innovations hit the market with reliable, repeatable safety data, regulatory agencies will keep red-lighting it. For shoppers and cooks, it’s a reminder: not all “natural” colors come risk-free, and regulatory red tape sometimes protects a lot more than it slows down.

Monascus Red
Names
Preferred IUPAC name (3S,6S,7R,8S)-8-[(E,2S,4S)-2-hydroxy-5-oxo-4-[(E)-2-oxoethenyl]pent-1-en-1-yl]-3,6-dimethyl-7-(2-oxopropyl)-2,3,6,7,8,9-hexahydro-1H-isochromene-4,5-dione
Other names Red yeast rice
Red kojic rice
Hongqu
Beni-koji
Ang-kak
Red mold rice
Pronunciation /ˈmɒnəskəs rɛd/
Preferred IUPAC name (3S,10S,11S,12Z,14E,16S)-10,11,16-trihydroxy-3-[(E)-prop-1-enyl]-6,8-dioxo-7,9-dioxa-13-azatetracyclo[7.7.1.0²,⁷.0¹⁰,¹⁴]heptadeca-1(15),2,4,12,14-pentaene-5-carboxylic acid
Other names Red yeast rice pigment
Red kojic rice pigment
Angkak pigment
Monascus color
Red mold rice pigment
Pronunciation /məˈnæskəs rɛd/
Identifiers
CAS Number 11042-48-9
Beilstein Reference 3770424
ChEBI CHEBI:82758
ChEMBL CHEMBL524702
ChemSpider 21570540
DrugBank DB13935
ECHA InfoCard 03b1a57b-069e-463e-b2aa-2c13c7ecdf5f
EC Number E160b
Gmelin Reference 108154
KEGG C08606
MeSH D048551
PubChem CID 124856
RTECS number UU3980000
UNII 36T0CAZ4IU
UN number UN1993
CAS Number 11042-48-9
Beilstein Reference 3949262
ChEBI CHEBI:82414
ChEMBL CHEMBL2108658
ChemSpider 11425010
DrugBank DB13921
ECHA InfoCard 08c6aa2d-be3a-4635-9b32-716f67bad59b
EC Number E162
Gmelin Reference 162221
KEGG C17745
MeSH D018798
PubChem CID 159325
RTECS number DH8225000
UNII TD6M5V939A
UN number UN1993
Properties
Chemical formula C21H23NO4
Molar mass 863.96 g/mol
Appearance Dark red to purple-red powder
Odor Slightly specific odor
Density 0.5–0.6 g/cm³
Solubility in water Soluble in water
log P 3.12
Acidity (pKa) 7.4
Basicity (pKb) 11.44
Dipole moment 6.12 Debye
Chemical formula C21H22O5
Molar mass 869.96 g/mol
Appearance Dark red to purple red powder
Odor Slightly fermented odor
Density 0.4-0.8 g/mL
Solubility in water Slightly soluble
log P 2.31
Acidity (pKa) 7.2
Basicity (pKb) 10.37
Viscosity Viscosity: 20-80 mPa·s
Dipole moment 2.56 Debye
Thermochemistry
Std molar entropy (S⦵298) 369.3 J/mol·K
Std molar entropy (S⦵298) 324.5 J·mol⁻¹·K⁻¹
Pharmacology
ATC code A16AX11
ATC code A16AX11
Hazards
Main hazards May cause respiratory irritation.
GHS labelling GHS07, GHS09
Pictograms GHS07, GHS09
Signal word Warning
Hazard statements Hazard statements: Not classified as hazardous according to GHS.
Precautionary statements Keep container tightly closed. Store in a cool, dry, and well-ventilated place. Avoid contact with eyes, skin, and clothing. Do not breathe dust. Wash thoroughly after handling. Use personal protective equipment as required.
NFPA 704 (fire diamond) 1-1-0
Flash point >100°C
Lethal dose or concentration LD₅₀ (mouse, oral): >10,000 mg/kg
LD50 (median dose) LD50 (median dose) of Monascus Red: >10,000 mg/kg (mouse, oral)
PEL (Permissible) 0.05 g/kg
REL (Recommended) 0.2 g/kg
IDLH (Immediate danger) Not established.
Main hazards May cause respiratory irritation.
GHS labelling GHS07, GHS09
Pictograms GHS07
Signal word Warning
Hazard statements H315, H319, H335
Precautionary statements P264, P270, P273, P280, P301+P312, P305+P351+P338, P308+P313, P501
NFPA 704 (fire diamond) 1-0-0
Flash point >100°C
LD50 (median dose) >5000 mg/kg (rat, oral)
NIOSH Not Listed
PEL (Permissible) 0.05 g/kg
REL (Recommended) 0.02 g/kg
Related compounds
Related compounds Monascus Yellow
Monascus Orange
Monascus Violet
Monascorubramine
Rubropunctatin
Monascin
Ankaflavin
Related compounds Monascus Yellow
Monascus Orange
Ankaflavin
Monascorubrin
Rubropunctatin