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Material Safety Data Sheet: Mequindox

Identification

Product Name: Mequindox
Chemical Name: 3-methyl-2-quinoxalinecarboxamide 1,4-dioxide
Other Names: Mequindox Dioxide; Methylquindox
Recommended Use: Veterinary drug, mainly used as feed additive for swine and poultry disease control
Supplier: Manufacturer or distributor address, email, and emergency contact phone number (information specific to your source)
CAS Number: 139-89-9
UN Number: Not classified under UN numbers for transport

Hazard Identification

Classification: Toxic by ingestion, possible carcinogen, harmful to aquatic organisms
Hazard Statements: H301: Toxic if swallowed; H315: Causes skin irritation; H319: Causes serious eye irritation; H361: Suspected of damaging fertility or the unborn child
Signal Word: Danger
Pictograms: Skull and Crossbones, Exclamation Mark, Health Hazard, Environmental Hazard
Precautionary Statements: Avoid contact with skin and eyes, do not breathe dust, wash hands thoroughly after handling, wear protective clothing and eye protection
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Potential Health Effects: Nausea, headache, dizziness, blood disorders, reproductive toxicity

Composition / Information on Ingredients

Chemical Name: Mequindox
Formula: C9H10N4O3
Content: >98% (depending on supplier specification)
Impurities: May contain trace levels of reaction by-products from synthesis
Synonyms: Not listed under major regulatory authorities as a mixture; pure substance
Relevant Exposure Limits: Not established for Mequindox; handle as a hazardous chemical

First Aid Measures

Inhalation: Move person to fresh air, keep at rest, provide oxygen if breathing is difficult, seek medical help immediately
Skin Contact: Remove contaminated clothing, wash exposed area with soap and water for at least 15 minutes, seek medical advice if irritation appears
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, seek medical attention
Ingestion: Do not induce vomiting, rinse mouth with plenty of water, call a poison center or doctor right away
Most important symptoms: Nausea, abdominal pain, headache, signs of methemoglobinemia
Advice for Doctors: Treat symptomatically and monitor methemoglobin levels

Fire-Fighting Measures

Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide. Avoid high-pressure water jets
Hazardous Combustion Products: Emits toxic fumes of nitrogen oxides, carbon monoxide, carbon dioxide
Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Special Procedures: Evacuate area, avoid inhaling vapors and combustion products, keep containers cool with water spray

Accidental Release Measures

Personal Precautions: Evacuate unnecessary personnel, ventilate area, wear suitable protection including gloves and goggles
Environmental Precautions: Prevent release to drains, water courses, or soil, contain spill
Cleanup Methods: Sweep up spills using methods that minimize dust generation, collect in appropriate containers for disposal, wash spill site with water and detergent after material pickup is complete
Notification: Report major releases to local environmental and safety authorities, as required by law

Handling and Storage

Handling: Use with adequate ventilation, avoid formation of dust, do not eat or drink while handling, wash thoroughly after use
Prevention of Fire and Explosion: Keep away from ignition sources, avoid buildup of dust, earth all equipment
Storage Conditions: Store in tightly closed original container in a cool, dry, well-ventilated area, separate from food and feedstuffs, away from acids and oxidizing agents
Incompatible Materials: Strong oxidizers, acids, bases
Specific End Uses: Intended for veterinary use, not for human consumption

Exposure Controls and Personal Protection

Engineering Controls: Local exhaust ventilation, process enclosure, or other engineering controls to keep airborne levels below recommended exposure limits
Personal Protection:
- Respiratory protection: Approved dust respirator if airborne concentrations are high
- Eye/face protection: Chemical-resistant goggles and face shield
- Skin protection: Chemical resistant gloves, lab coat, or suitable body-covering clothing
Hygiene Measures: Do not smoke, eat, or drink while working with compound, wash hands and face before breaks and at end of work
Workplace Monitoring: Routine monitoring recommended for airborne dust and surface contamination

Physical and Chemical Properties

Appearance: Pale yellow to tan crystalline powder
Odor: Odorless or faint chemical odor
pH: Not readily soluble; pH not directly applicable
Melting Point: 204°C - 207°C
Boiling Point: Decomposes before boiling
Flash Point: Data not available
Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol
Vapor Pressure: Not significant at room temperature
Density: Approximately 1.6 g/cm³
Partition Coefficient (log Kow): Approximately 0.1 - 0.5 (estimated)
Stability: Stable under normal handling and storage conditions but decomposes with heat

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions, decomposes at elevated temperatures
Reactivity: Not reactive with common materials but reacts with strong oxidizing agents
Possibility of Hazardous Reactions: No hazardous polymerization expected
Conditions to Avoid: Heat, moisture, direct sunlight, ignition sources
Incompatible Materials: Strong oxidizers, acids, bases
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, toxic fumes

Toxicological Information

Acute Toxicity: LD50 Oral – Rat: 36 mg/kg (reported); toxic in small doses
Chronic Effects: Suspected carcinogen, reproductive toxicity, blood system effects including methemoglobinemia and anemia
Route of Exposure: Inhalation, dermal, oral
Symptoms: Nausea, vomiting, central nervous system depression, blue discoloration of skin (methemoglobinemia), hemolysis, organ toxicity
Mutagenic/Genotoxic Effects: Positive in some bacterial and animal tests
Carcinogenicity: Animal studies show potential cancer risk; not listed as a human carcinogen by IARC but regulatory bodies impose use restrictions due to concerns
Reproductive Toxicity: Studies indicate possible teratogenic and fertility effects at high doses
Skin/Eye Irritation: Causes skin and eye irritation
Target Organs: Liver, kidneys, blood system, reproductive organs

Ecological Information

Ecotoxicity: Harmful to aquatic organisms, potential for bioaccumulation in the environment
Aquatic Toxicity: LC50 (fish, 96h): <1 mg/L (estimated, species-specific values may vary)
Persistence and Degradability: Not rapidly biodegradable; persists in sediment and water
Bioaccumulation Potential: Moderate accumulation reported in aquatic species
Mobility in Soil: Limited mobility, tends to adsorb to organic matter
Other Adverse Effects: Chronic exposure may cause long-term adverse effects in aquatic environments, concern for environmental contamination from animal waste containing residues

Disposal Considerations

Waste Treatment Methods: Dispose as hazardous chemical waste, follow local, regional, and national regulations
Disposal of Product: Incinerate in approved facility or use landfill only if permitted; do not discharge into drains, water courses, or environment
Disposal of Contaminated Packaging: Rinse containers thoroughly, offer for chemical recycling or incineration
Special Precautions: Do not mix with household waste or dump uncontrolled, transport to licensed hazardous waste site
Decontamination Procedures: Use strong detergent and water; absorb liquid spillage with inert material before cleaning

Transport Information

UN Number: Not classified as dangerous for transport by land, air, or sea
Proper Shipping Name: Mequindox (not regulated)
Transport Hazard Class: Not regulated under standard international guidelines
Packing Group: Not assigned
Environmental Hazards: Avoid shipment with foodstuffs and aquatic environments, prevent package rupture
Special Precautions: Ensure containers are tightly sealed, clearly labelled, protected from rough handling and direct sunlight

Regulatory Information

European Union Regulations: Not permitted as veterinary drug in the EU due to toxicity concerns; included in monitoring programs
U.S. Regulations: Not FDA approved for use in food-producing animals; restricted or banned in several countries
China: Permitted as a feed additive in specific cases, subject to maximum residue limits and withdrawal periods
Occupational Exposure Limits: Not assigned by OSHA, NIOSH, or ACGIH
Labelling Requirements: Must be clearly labelled as hazardous and for professional use only
Environmental Regulations: Subject to wastewater discharge and animal waste management controls in certain jurisdictions
Other Information: Typically restricted to use by licensed professionals under controlled conditions; monitoring of residues in animal-derived food is required by law in some countries