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Product Name: Melatonin
Chemical Name: N-Acetyl-5-methoxytryptamine
CAS Number: 73-31-4
Molecular Formula: C13H16N2O2
Molecular Weight: 232.28 g/mol
Synonyms: 5-Methoxy-N-acetyltryptamine
Recommended Use: Dietary supplement, laboratory chemical
Supplier: Refer to the manufacturer or distributor label
Contact Information: Emergency telephone and address available on product package or SDS repository
GHS Classification: Not classified as hazardous under standard regulatory definitions
Signal Word: No signal word applies
Hazard Statements: May cause mild skin or eye irritation in sensitive individuals, not known to be acutely toxic
Pictograms: No pictograms required
Precautionary Statements: Avoid unnecessary handling, ingestion, and inhalation; avoid eye and skin contact
Potential Health Effects: Prolonged contact may cause mild irritation; ingestion in large amounts could produce drowsiness; unlikely to cause severe acute hazards in normal use
Chemical Name: Melatonin
Concentration: Greater than 99% (pure form)
CAS Number: 73-31-4
Impurities/Additives: None significant for classification; check supplier for minor contaminants
Inhalation: Move person to fresh air, provide oxygen if breathing becomes difficult, seek medical attention if symptoms persist
Skin Contact: Wash with soap and water for several minutes, remove contaminated clothing, consult medical aid if irritation develops
Eye Contact: Rinse eyes immediately with running water for at least 15 minutes holding eyelids open, remove contact lenses, get medical help if redness or irritation continues
Ingestion: Rinse mouth with water, get medical advice if feeling unwell; drowsiness possible at high doses, watch for respiratory depression or confusion
Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide to extinguish fire involving this product
Specific Hazards: Forms hazardous decomposition products like carbon oxides and nitrogen oxides in a fire, dust can form explosive mixtures with air
Protective Equipment: Firefighters should use self-contained breathing apparatus and full protective gear
Advice for Responders: Avoid breathing smoke, contain runoff to avoid contamination of water systems
Personal Precautions: Wear gloves, goggles, and protective clothing, prevent dust formation and inhalation
Environmental Precautions: Prevent large spills from entering drains or soil, avoid release to natural waterways
Spill Response: Scoop or sweep up material for disposal in a suitable container, use HEPA filter vacuum for final cleanup, ventilate contaminated area thoroughly
Safe Handling: Use in a well-ventilated space, minimize dust generation, wash hands after handling, avoid swallowing, keep containers tightly closed
Storage Conditions: Store in cool, dry, and well-ventilated location away from sunlight, moisture, oxidizers, and incompatible materials
Special Precautions: Keep away from food and beverages, maintain proper labeling, store in original container when possible
Exposure Limits: No occupational exposure limits established by OSHA, ACGIH, or NIOSH for melatonin
Engineering Controls: Use local exhaust or general ventilation to control airborne dust
Eye Protection: Chemical safety goggles
Skin Protection: Wear chemical-resistant gloves and lab coats
Respiratory Protection: Use NIOSH-approved respirator for dust if airborne concentrations exceed recommended levels
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing, avoid eating or drinking while handling
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Not determined for solid
Melting Point: 116–118°C
Boiling Point: Not available
Flash Point: Not determined
Evaporation Rate: Not applicable
Flammability: May form combustible dust concentrations in air
Vapor Pressure: Not significant
Vapor Density: Not determined
Solubility: Slightly soluble in water, soluble in ethanol and DMSO
Partition Coefficient: Log Pow 0.71
Auto-Ignition Temperature: Not available
Decomposition Temperature: No data
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions, unaffected by common handling within recommended temperature and humidity
Reactivity: Does not react violently under standard laboratory or industrial conditions
Hazardous Reactions: Avoid contact with strong oxidizers, acids, or bases that may degrade the compound
Decomposition Products: Releases carbon monoxide, carbon dioxide, and nitrogen oxides under fire or intense heat
Incompatibility: Strong oxidizing agents may produce exothermic reactions or decompose material
Acute Toxicity: Low toxicity by oral, dermal, or inhalation routes in animal studies; oral LD50 (rat) >3200 mg/kg
Chronic Effects: Prolonged or repeated exposure not expected to cause significant health effects in humans to date
Irritation: May cause mild irritation to eyes and skin in susceptible individuals
Sensitization: Not classed as a skin or respiratory sensitizer
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a probable or confirmed carcinogen
Mutagenicity: Not found mutagenic in standard laboratory assays
Reproductive Effects: No significant reproductive toxicity reported at typical supplement or clinical doses, always consult current toxicological reviews
Environmental Impact: Limited data on environmental persistence and bioaccumulation; not expected to present significant hazard under normal product lifecycle use
Aquatic Toxicity: Not considered acutely toxic to aquatic organisms at standard concentrations, avoid discharge into waterways as a best practice
Degradability: Melatonin expected to degrade in biological wastewater treatment, final fate depends on environmental conditions
Bioaccumulation: Low potential, based on low Log Pow value
Other Effects: Excessive discharge or spills may alter aquatic organism behavior
Waste Disposal Methods: Dispose of material in accordance with local, regional, or national regulations, avoid direct release to water sources or landfills where not permitted
Unused Product: Send to licensed chemical disposal facility
Contaminated Packaging: Clean or dispose of containers following hazardous waste guidelines
Precautions: Follow state and federal directives for pharmaceutical or chemical disposal, do not pour down drain unless sewer system authority approves small laboratory quantities
UN Number: Material not regulated as a dangerous good
Transport Hazard Classes: Not applicable
Packing Group: Not assigned
Proper Shipping Name: Melatonin, not restricted
Environmental Hazards: Not expected to pose an environmental hazard during transport
Special Precautions: Transport in tightly sealed, labeled containers away from food and feedstuffs, keep dry and protected from temperature extremes
US Regulations: Melatonin is not listed as a hazardous substance under TSCA, CERCLA, SARA Title III, or RCRA
EU Classification: Not classified as hazardous under CLP Regulation (EC No 1272/2008), used as a nutraceutical and pharmaceutical ingredient
Canada: Not controlled under WHMIS
Labeling Requirements: Must follow labeling and packaging guidelines for dietary supplements and/or laboratory chemicals, including hazard statements for informational purposes
Other Regulations: Local workplace safety regulations apply, handle according to best modern safety standards and regular reviews of global chemical safety guidelines
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
