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Product Name: Lipoic Acid
Synonyms: Thioctic acid, α-Lipoic acid, 1,2-Dithiolane-3-pentanoic acid
CAS Number: 1077-28-7
Molecular Formula: C8H14O2S2
Recommended Use: Laboratory chemicals, dietary supplement manufacture
Manufacturer Contact: Refer to supplier label for current emergency numbers and detailed information on supplier address
GHS Classification: Eye irritation Category 2A, Skin irritation Category 2
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation. May cause respiratory irritation.
Pictograms: Exclamation mark
Precautionary Statements: Wear protective gloves and eye/face protection. Avoid breathing dust or vapors. Wash hands thoroughly after handling. Use in a well-ventilated area.
Potential Health Effects: Irritation to eyes and skin, may worsen asthma-like symptoms for sensitive individuals. Ingestion may result in gastrointestinal symptoms such as nausea and vomiting.
Component: Alpha-Lipoic Acid
Chemical Formula: C8H14O2S2
Concentration: >98% (typical for reagent grade)
Impurities: Minor organic impurities may be present at <0.5%. Specific information available from supplier.
General Advice: Remove exposed individual from area and seek fresh air. Remove contaminated clothing.
Inhalation: Move person to fresh air. Keep at rest. Obtain medical attention if symptoms continue.
Skin Contact: Rinse skin with water for at least 15 minutes. Wash with soap and water.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present. Seek medical attention for persistent irritation.
Ingestion: Rinse mouth with water. Do not induce vomiting unless directed by medical personnel. Medical advice is necessary if large quantities are ingested or symptoms develop.
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Extinguishing Media: High-pressure water jet can spread material
Specific Hazards: May emit toxic fumes of sulfur oxides and carbon oxides when burned
Protective Equipment & Precautions: Firefighters should wear approved self-contained breathing apparatus and full protective clothing. Prevent runoff from entering drains or water bodies.
Special Firefighting Procedures: Cool containers with water spray to prevent heating. Avoid inhalation of combustion byproducts.
Personal Precautions: Wear goggles, gloves, NIOSH-approved respiratory protection, and clothing to avoid contact
Environmental Precautions: Prevent product entering drains, surface water, or groundwater systems
Methods for Cleanup: Sweep up without raising dust. Place in secure, labeled containers for disposal. Wash spill area with soap and water. Ventilate affected area.
Handling: Minimize dust generation and accumulation. Keep containers closed. Wash hands after handling. Do not eat, drink, or smoke during use.
Storage: Store in a dry, cool, and well-ventilated area away from incompatible materials such as oxidizers. Keep away from sources of ignition. Protect from direct sunlight.
Incompatible Materials: Strong oxidizing agents, bases, and acids can cause hazardous reactions.
Engineering Controls: Use local exhaust ventilation or general room ventilation to maintain dust concentrations below recommended exposure limits.
Exposure Limits: No occupational exposure limits established by OSHA, ACGIH, or NIOSH for lipoic acid. Practice general chemical hygiene.
Personal Protective Equipment: Safety goggles, gloves (nitrile or other chemical-resistant variety), lab coat. Where dust generation risk is high, use a dust mask or respirator certified for particulate hazards.
Hygiene Measures: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse.
Appearance: Yellow crystalline powder
Odor: Slight characteristic odor
Melting Point: 60–62°C
Boiling Point: Decomposes before boiling
Solubility: Slightly soluble in water; soluble in ethanol and organic solvents like DMSO
pH: Not applicable (neat substance); in solution, weakly acidic
Vapor Pressure: Negligible at room temperature
Relative Density: Approx. 1.23 g/cm³ (20°C)
Flash Point: >110°C (closed cup method)
Auto-Ignition Temperature: Not established
Partition Coefficient (Log Pow): 0.23
Decomposition Temperature: 160–165°C
Chemical Stability: Stable under recommended conditions for storage and handling.
Reactivity: May react with strong oxidizing agents.
Hazardous Reactions: None under normal use. Can form combustible dust-air mixtures.
Conditions to Avoid: High temperatures, flames, sparks, moisture, direct sunlight.
Hazardous Decomposition Products: Sulfur oxides and carbon oxides on combustion or decomposition.
Acute Toxicity: Oral LD50 (rat): 400–500 mg/kg. Toxic if ingested in large quantities.
Skin Contact: May cause mild to moderate irritation after prolonged exposure.
Eye Contact: Causes eye irritation, especially at high concentrations.
Inhalation: Inhalation of dust may cause respiratory irritation.
Chronic Effects: No data showing long-term health impacts in humans under normal exposure.
Carcinogenicity: Classified as non-carcinogenic based on available animal data.
Mutagenicity: Not found to be mutagenic in standard laboratory tests.
Developmental/Reproductive Toxicity: No evidence of reproductive toxicity at recommended exposure levels.
Ecotoxicity: Limited data available. Based on chemical structure, not expected to be highly toxic to aquatic organisms but should not be released directly to environment.
Persistence and Degradability: Expected to biodegrade over time; not considered persistent
Bioaccumulation Potential: Low, due to low Log Pow value
Mobility in Soil: Likely to be relatively mobile, especially with rainfall. Take measures to prevent runoff.
Other Adverse Effects: Avoid direct release to aquatic environment.
Waste Treatment Methods: Collect and dispose of in accordance with local, state, and national regulations.
Product Disposal: Suitable incineration by a licensed chemical disposal company recommended.
Contaminated Packaging: Dispose of as hazardous waste. Wash and recycle or incinerate according to local requirements.
Precautions: Do not release to drains or watercourses. Carefully label all waste containers.
UN Number: Not classified as hazardous for transport
UN Proper Shipping Name: Not regulated
Transport Hazard Classes: Not applicable
Packing Group: Not applicable
Environmental Hazards: Avoid release to environment during transport
Special Precautions: Ensure containers are properly sealed and labeled. Minimize movement if container compromised.
US Regulations: Not listed by TSCA as a hazardous material. Meets safety standards for dietary supplement ingredient within GMP manufacturing.
EU Regulations: Not classified as dangerous under Regulation (EC) No. 1272/2008. Not listed on REACH Annex XIV.
Canadian Regulations: WHMIS classification not applicable.
Other Regulatory Status: Check regional requirements for additional stipulations for worker safety, labeling, and environmental release.
West Ujimqin Banner, Xilingol League, Inner Mongolia, China
