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Product Name: Lincomycin Hydrochloride
Synonyms: (2S,4R)-N-[(1S,2S)-1-Methyl-4-propyl-L-2-pyrrolidinecarboxamidomethyl]-1,2,3,4-tetrahydro-beta-D-thiopyran-4-carboxamide monohydrochloride
CAS Number: 859-18-7
Recommended Use: Veterinary antibiotic, pharmaceutical ingredient
Supplier Details: Contact local distributor, manufacturing facility, or pharmaceutical provider for company information
Emergency Phone Contact: Access via local regulations, medical professionals, or poison control
Classification: Health hazard, irritant, sensitizer according to GHS and local chemical safety frameworks
Hazard Statements: Causes eye irritation, potential skin sensitization, possible respiratory tract irritation on inhalation; allergic reactions possible among sensitive individuals
Precautionary Statements: Avoid contact with skin, eyes, and clothing; refrain from inhaling dust or powder; use only in well-ventilated spaces; wear appropriate protection
Signal Word: Warning
Pictograms: Exclamation mark (GHS), Health hazard
Emergency Overview: Fine powder, white to off-white, mild medicinal odor, poses inhalation hazard, must be handled with caution
Chemical Name: Lincomycin Hydrochloride
Percent of Mixture: > 98% active ingredient
Impurities: Typically contains trace levels of related substances as per pharmacopeial standards
Other Components: No significant additives in raw bulk material form
Molecular Formula: C18H34N2O6S·HCl
Molecular Weight: Approximately 461.0 g/mol
Inhalation: Remove person to fresh air, monitor breathing, provide artificial respiration if needed, seek medical advice
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, watch for irritation or allergy; obtain medical attention if discomfort persists
Eye Contact: Rinse immediately with plenty of clean, lukewarm water; continue for at least 15 minutes and consult medical professional if irritation appears
Ingestion: Rinse mouth; provide water if person is fully conscious; avoid giving anything by mouth to an unconscious individual; call poison control or seek urgent medical care
Notes for Medical Staff: Symptomatic and supportive care recommended, monitor for allergic reactions
Flammability: Not readily combustible, but dust can form explosive mixtures with air under certain conditions
Suitable Extinguishing Media: Use water spray, dry chemical powder, foam, or carbon dioxide; select extinguishing agent suited for surrounding materials
Unsuitable Media: Strong water jets may spread powder
Hazards from Combustion Products: Emits oxides of carbon, nitrogen, and sulfur, along with hydrochloric acid fumes
Special Protective Equipment: Self-contained breathing apparatus and full protective firefighting gear required
Firefighting Advice: Move containers from fire area if safe, avoid run-off entering water systems, fight fire from safe distance
Personal Precautions: Restrict access to area, ventilate space, avoid dust formation, wear respiratory protection and chemical-resistant gloves
Environmental Precautions: Prevent release into sewers, drains, or waterways, take steps to contain spill
Cleanup Procedures: Carefully scoop up or use approved HEPA vacuum, collect for suitable disposal; decontaminate area with water and soap, avoid generating dust
Disposal of Contaminated Materials: Place in labeled containers, follow local regulatory guidance
Precautions for Safe Handling: Minimize dust generation, avoid contact with eyes, skin, clothing; use containment equipment and proper ventilation; handle with care in designated chemical areas
Storage Requirements: Store in tightly closed containers, away from incompatible materials like strong oxidizers and acids, keep in a cool, dry, well-ventilated space; protect from light and moisture
Special Considerations: Label storage location clearly, restrict access to authorized, trained personnel; avoid contamination of other veterinary products or pharmaceuticals
Occupational Exposure Limits: No specific regulatory limits published, use good industrial hygiene practices; implement internal OEL if available
Engineering Controls: Perform handling in enclosed systems or utilize local exhaust ventilation, use HEPA filtration where necessary
Respiratory Protection: Use approved respirators for dust exposure above recommended levels
Protective Clothing: Wear laboratory coats and protective gloves resistant to chemicals
Eye/Face Protection: Safety goggles or face shields required
Hygiene Practices: Remove contaminated clothing promptly, wash hands thoroughly after use, no eating, drinking, or smoking during handling
Appearance: White to almost white powder
Odor: Faint medicinal odor
pH (1% solution): Approximately 3.0 to 5.0
Melting Point: About 153°C (decomposes)
Solubility: Readily soluble in water, slightly soluble in alcohol
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Vapor Pressure: Negligible at ambient temperatures
Density: Not established precisely due to powder form
Partition Coefficient: Not readily available
Other Information: Stable under recommended storage and handling
Chemical Stability: Stable under normal storage, light sensitivity possible
Reactivity: Avoid strong oxidizers and acids, hydrolysis possible at elevated temperatures or in strongly acidic or alkaline conditions
Decomposition Products: Produces toxic or corrosive fumes: hydrochloric acid, nitrogen oxides, sulfur oxides on burning or decomposition
Polymerization: Hazardous polymerization unlikely
Conditions to Avoid: Excess moisture, strong heat, incompatible substances as mentioned
Acute Effects: Inhalation may cause irritation to respiratory tract, skin contact may lead to rash or sensitization, eye exposure irritates conjunctiva
Chronic Effects: Prolonged or repeated exposure increases risk of skin allergy, possible detrimental effects on liver and kidneys in preclinical studies
Routes of Exposure: Inhalation, ingestion, dermal, eye
Symptoms: Coughing, wheezing, rash, headache, nausea in severe cases
Carcinogenicity: No classification as carcinogenic by IARC, NTP, or ACGIH
Mutagenicity and Teratogenicity: No significant evidence in standard test systems
Medical Conditions Aggravated: Hypersensitive individuals, those with preexisting allergies or respiratory conditions may react more acutely
Ecotoxicity: Harmful to aquatic organisms, may cause long-term adverse effects in aquatic environments based on antibiotic action
Persistence and Degradability: Biodegradation slow in environment, potential for bioaccumulation exists
Mobility in Soil: Moderate; may leach to groundwater if released
Aquatic Toxicity: Studies on algae, daphnia, and fish indicate adverse effects at low concentrations
Behavior in Sewage Plants: Removal possible with standard treatment, but resistant organisms may proliferate; proper containment crucial
Waste Disposal Methods: Dispose in approved chemical waste facility or by incineration; follow all local, regional, national, and international regulations
Contaminated Containers: Triple-rinse, puncture, and dispose of in compliance with hazardous waste guidelines
Special Considerations: Do not discharge to environment or household waste; avoid water contamination; label waste clearly for hazardous substances
UN Number: Not classified as dangerous under current transport regulations (ADR, IMDG, IATA)
Shipping Name: Lincomycin Hydrochloride
Transport Hazard Class: Not assigned
Packing Group: Not regulated as hazardous material
Special Precautions: Prevent dust release during handling and transport, secure containers to prevent spillage; consider PPE for handlers
International Listings: Check for inclusion in country- or region-specific chemical inventories where applicable (e.g., EU REACH, US TSCA)
SARA Title III (USA): Not listed as a hazardous substance or extremely hazardous substance
OSHA Status: Not specifically regulated; handle as pharmaceutical-grade chemical
WHMIS (Canada): Controlled Product – consult local workplace labeling regulations
Other Regulations: Subject to veterinary drug laws, prescription controls, environmental protection regulations in production and transportation; observe guidelines for pharmaceutical substances
