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Product Name: Lactobacillus rhamnosus
Synonyms: L. rhamnosus, Probiotic Bacterial Culture
Recommended Uses: Food supplements, fermentation, probiotic research and applications
Supplier: Manufacturer and distributor information available on request
Contact for Emergency: Local Poison Control Center, facility safety officer, or supplier emergency contact
CAS Number: 11137-65-4
Hazard Classification: Not classified as hazardous under GHS
Route of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Health Effects: Rare allergic response in sensitized individuals, mild irritation to eyes or skin possible in concentrated forms
Chronic Health Effects: No long-term adverse effects documented
Environmental Hazard: No significant environmental risk identified
Label Elements: Not required for non-pathogenic organisms like this strain
Pictogram: None
Signal Word: None
Precautionary Statements: Avoid inhaling dust, use with proper hygiene
Chemical Name: Lactobacillus rhamnosus
Type: Non-pathogenic Gram-positive bacterium
Concentration: Not less than 1x10⁹ colony forming units (CFU) per gram (for commercial powders)
Additional Ingredients: May include inert cryoprotectants, carriers such as maltodextrin or skim milk, and stabilizing agents
Impurities: Non-pathogenic, free from known toxins and common pathogens on certificate of analysis
Allergens: Varies by carrier, always check label for dairy or other allergens
General Information: Move subject to fresh air. Consult physician if symptoms arise.
Eye Contact: Rinse gently with water for several minutes. Remove contact lenses if present and easy to do. Seek medical advice if irritation persists.
Skin Contact: Wash with water and mild soap. Remove contaminated clothing and launder before reuse.
Inhalation: Remove to fresh air. Seek medical attention if breathing difficulty continues.
Ingestion: Rinse mouth. Drink water if able. Medical attention only needed for persistent discomfort.
Notes for Doctor: No specific antidote. Treat symptomatically.
Suitable Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ for fires involving this product as a component.
Unsuitable Extinguishing Media: None known for pure cultures or lyophilized product.
Hazardous Combustion Products: None anticipated; may produce nitrogen oxides, carbon dioxide, and carbon monoxide in extreme heat.
Protective Equipment: Firefighters should wear self-contained breathing apparatus, protective gloves, and clothing.
Special Firefighting Procedures: Limit spread of dust, avoid breathing aerosolized material, and minimize water runoff.
Personal Precautions: Avoid inhaling dust, wear gloves and goggles if handling large quantities.
Methods for Cleanup: Sweep up material, avoiding generation of airborne dust. Store in a sealed, labeled bag or container for disposal.
Spill Response: Small quantities can be flushed to drain with water unless restricted by local regulation.
Environmental Precautions: Prevent release to waterways in bulk quantities. Notify authorities if large amounts enter environment.
Disposal of Contaminated Material: Place in suitable waste containers. Dispose according to section 13.
Handling: Keep container tightly closed. Avoid dust generation. Wash hands thoroughly after handling.
Storage: Store refrigerated (2–8°C) and protect from light. Keep away from food and drink. Do not freeze unless specified by supplier.
Incompatibilities: None known for routine use.
Safe Transfer: Use in well-ventilated area, use tools for transfer from bulk packages, avoid skin contact.
Recommended Container: Food-grade plastic bottles, glass containers with sealed lids.
Engineering Controls: Work in areas with adequate ventilation, use biological safety cabinet for high concentrations.
Personal Protective Equipment: Laboratory coat, safety goggles, disposable gloves recommended for bulk handling.
Respiratory Protection: Dust mask or respirator for airborne powders.
Environmental Exposure Controls: Prevent contamination of work surfaces and drainage system.
Hygiene Measures: Avoid eating, drinking, or smoking where product is handled, and wash hands after use.
Appearance: Off-white or pale yellow powder, may be granular or freeze-dried cake
Odor: Slight fermentation odor, not unpleasant
pH (1% solution): 5.0 to 7.0
Boiling Point: Not applicable
Melting Point: Not applicable
Solubility: Dispersible in water, not truly soluble
Bulk Density: 0.3-0.8 g/cm³
Flammability: Not classified as flammable in typical concentrations
Other properties: Stable under recommended storage; sensitive to moisture and heat
Stability: Stable under recommended storage conditions, loss of viability increases at higher temperatures
Reactivity: Not reactive with ordinary materials
Hazardous Decomposition: None under normal use
Hazardous Polymerization: Will not occur
Incompatible Materials: Strong oxidizing agents may inactivate
Conditions to Avoid: Heat, moisture, direct sunlight
Acute Toxicity: No evidence of acute toxicity in healthy individuals
Chronic Toxicity: No known chronic toxicity for healthy individuals when ingested or used as intended
Sensitization: Rare cases of allergic reaction in immunocompromised or highly sensitive individuals reported
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA
Reproductive Effects: No adverse reproductive or developmental effects observed
Mutagenicity: Studies show no mutagenic risk
Medical Surveillance: Monitoring recommended for workers with underlying immunodeficiency, respiratory conditions
Ecotoxicity: Non-toxic to aquatic life at environmental exposure levels
Persistence/Degradability: Rapidly degrades and competes with native microflora
Bioaccumulative Potential: Does not bioaccumulate
Mobility in Soil: Limited due to biological competition and environmental conditions
Other Adverse Effects: No known environmental hazards; may temporarily alter local microbial ecology
Regulatory Status: Generally Recognized As Safe (GRAS) for use in food and environmental release in many jurisdictions
Product Disposal: Dispose as non-hazardous biological waste in accordance with local, regional, and national regulations
Contaminated Packaging: Rinse and recycle if possible, or dispose as municipal waste per standard protocol
Disposal Methods: Autoclave or landfilling with general non-hazardous waste where permitted
Precautions for Workers: Wear protective equipment, prevent release to water systems in bulk amounts
UN Number: None assigned; non-hazardous for transport
Proper Shipping Name: Lactobacillus rhamnosus culture powder
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Marine Pollutant: No
Special Transport Precautions: Keep dry, maintain temperature as stated by supplier
International Regulations: Classified as a non-pathogenic microorganism; not subject to international transport restrictions
US Regulations: Not regulated as hazardous under OSHA, TSCA, or CERCLA
EU Regulations: Not classified as hazardous under REACH
Food and Feed Additive Approvals: Holds GRAS status with the US FDA for most food applications
GMO Status: Most commercial strains non-GMO, check documentation for any genetically modified variants
Worker Protection: No specific OSHA PEL or ACGIH TLV published; general dust limits apply
Other Legal Requirements: Users responsible for compliance with local, state, and national regulations
