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Material Safety Data Sheet: L-Tryptophan

Identification

Product Name: L-Tryptophan
Chemical Name: (S)-2-Amino-3-(1H-indol-3-yl)propanoic acid
CAS Number: 73-22-3
Molecular Formula: C11H12N2O2
Molecular Weight: 204.23 g/mol
Synonyms: L-α-Amino-3-indolepropionic acid
Recommended Use: Dietary supplement, pharmaceutical manufacturing, laboratory reagent
Manufacturer/Supplier: Please refer to specific supplier data
Emergency Telephone Number: Refer to local regulations or supplier contact

Hazard Identification

Classification: Not classified as hazardous according to GHS
Label Elements: Signal word not required; pictograms not mandatory
Hazard Statements: Inhalation of dust may cause mild respiratory irritation; ingestion in large amounts could disrupt gastrointestinal systems
Precautionary Statements: Avoid inhaling dust; avoid prolonged or repeated skin contact; keep out of reach of children
Potential Health Effects: Eye irritation from dust; mild skin irritation; gastrointestinal upset if ingested in excess; minimal chronic effects noted in healthy adults
Environmental Hazards: Not expected to be hazardous for the environment at standard workplace quantities, but avoid uncontrolled release

Composition / Information on Ingredients

Chemical Name: L-Tryptophan
CAS Number: 73-22-3
Purity: Typically >98%
Impurities: None expected at relevant industrial and laboratory purity levels
Formulation: Usually provided as a crystalline or powdered solid
Additives: Preservatives, solvents, or excipients are typically not present unless specified in a particular batch

First Aid Measures

Eye Contact: Rinse gently with plenty of water for several minutes; remove contact lenses if present and easy to do; seek medical attention for persistent irritation
Skin Contact: Wash affected area with soap and water; remove contaminated clothing; if irritation develops, consult medical advice
Inhalation: Move the person to fresh air; monitor for symptoms like cough or shortness of breath; seek medical attention if symptoms continue
Ingestion: Rinse mouth; drink water to dilute; do not induce vomiting; seek medical attention if feeling unwell
Acute Effects: Mild irritation possible; serious systemic effects are rare at typical exposure levels

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, foam
Unsuitable Extinguishing Media: High-pressure water jets may cause dust dispersal
Specific Hazards: Dust may form explosive mixtures with air if concentrations become high; combustion may release carbon oxides, nitrogen oxides, and indole derivatives
Protective Equipment: Wear full protective gear and self-contained breathing apparatus for large fires
Special Precautions: Keep containers cool with water spray; control run-off to prevent environmental contamination

Accidental Release Measures

Personal Precautions: Wear protective clothing, gloves, and safety glasses; avoid breathing dust
Environmental Precautions: Prevent entry into waterways, drains, soil, and enclosed working areas
Containment and Cleaning Methods: Sweep or vacuum carefully to minimize dust generation; collect spills in a suitable container for safe disposal; ventilate the area
Emergency Procedures: Evacuate unprotected personnel; follow local protocols for chemical spill response

Handling and Storage

Handling: Work in a well-ventilated area; avoid creating or inhaling dust; always wash hands after use
Storage: Store in a tightly sealed container, away from moisture and strong oxidizing agents; keep in a cool, dry, well-ventilated place away from incompatible substances
Special Instructions: Label containers clearly; store away from food and beverages; ensure all equipment is grounded to prevent static sparks

Exposure Controls and Personal Protection

Engineering Controls: Use local exhaust ventilation or process enclosures to minimize dust exposure
Respiratory Protection: Respirators suitable for nuisance dust if workplace concentrations exceed recommended levels; NIOSH-approved particulate respirators
Skin Protection: Chemical-resistant gloves such as nitrile or latex
Eye Protection: Safety goggles or face shields for bulk handling
Hygiene Measures: Wash thoroughly after handling; remove contaminated clothing and wash before reuse
Occupational Exposure Limits: Not established for L-Tryptophan; follow general nuisance dust recommendations (e.g., OSHA/NIOSH for Particulates Not Otherwise Classified)

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Slight characteristic odor
Odor Threshold: Not established
pH: Approximately 5.5 (1% aqueous solution)
Melting Point: 290°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not flammable in solid form
Evaporation Rate: Not applicable
Flammability (solid, gas): May form combustible dust concentrations in air
Explosive Limits: Not determined
Vapor Pressure: Negligible at room temperature
Vapor Density: Not applicable
Solubility: Slightly soluble in water
Partition Coefficient (n-octanol/water): -1.07
Auto-ignition Temperature: Not established
Decomposition Temperature: Above 290°C
Viscosity: Not applicable

Stability and Reactivity

Chemical Stability: Stable under normal conditions of storage and handling
Hazardous Reactions: Reacts with strong oxidizers
Conditions to Avoid: Extreme heat, sparks, open flame, presence of strong acids or bases
Incompatible Materials: Strong oxidizing agents, strong acids
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, indole compounds

Toxicological Information

Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Acute Toxicity: Oral LD50 (rat) > 5,000 mg/kg indicating low toxicity
Skin Corrosion/Irritation: Mild irritation possible
Eye Damage/Irritation: May cause mechanical irritation
Respiratory Effects: Dust may cause transient nose or throat irritation
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA
Reproductive Toxicity: No evidence from available data
Sensitization: No reports of skin or respiratory sensitization
Chronic Toxicity: No long-term health hazards reported under normal handling

Ecological Information

Ecotoxicity: L-Tryptophan is not considered toxic to aquatic organisms in environmental concentrations expected from workplace use
Persistence and Degradability: Biodegradable in the environment under aerobic conditions
Bioaccumulation Potential: Low; not expected to bioaccumulate due to high water solubility
Mobility in Soil: High mobility due to solubility in water
Other Adverse Effects: No significant environmental effects anticipated; avoid uncontrolled release to prevent nutrient loading in water systems

Disposal Considerations

Waste Disposal Methods: Dispose of in accordance with local, state, and federal regulations
Uncontaminated Product: May be landfilled or incinerated as permitted by regulations
Contaminated Packaging: Thoroughly rinse before disposal or send to licensed waste handler
Precautions for Disposal: Avoid release into drains, water courses, or the environment; do not mix with incompatible wastes
Special Instructions: Consult with appropriate authorities for large-scale disposal

Transport Information

UN Number: Not required as L-Tryptophan is not regulated as a hazardous material
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not classified
Packing Group: Not assigned
Marine Pollutant: No
Special Transport Precautions: Protect against physical damage and moisture; avoid packaging with incompatible substances
Transportation Modes: Suitable for transport by road, rail, sea, and air under standard commercial practices

Regulatory Information

OSHA: Not specifically regulated, general workplace safety rules apply
TSCA (US): Listed
DSL (Canada): Listed
REACH (EU): Exempted as a naturally occurring amino acid
WHMIS (Canada): Not controlled
California Prop 65: Not listed
SARA Title III: Not subjected to reporting requirements
Other Regulations: Follow all federal, state, and local regulations for workplace chemical safety and environmental protection