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L-Threonine Material Safety Data Sheet (MSDS)

Identification

Product Name: L-Threonine
Chemical Formula: C4H9NO3
CAS Number: 72-19-5
Synonyms: 2-Amino-3-hydroxybutanoic acid
Intended Use: Feed additive, nutritional supplement, laboratory reagent
Manufacturer Information: Provided on product label and supply contract
Contact Numbers: Emergency and technical support numbers supplied by manufacturer

Hazard Identification

GHS Classification: Not classified as hazardous according to OSHA or EU criteria
Main Hazards: May cause slight irritation to eyes, skin, or respiratory tract in dust-rich environments
Pictograms: No hazard pictogram required
Signal Word: None
Precautionary Statements: Avoid creating dust clouds, use with adequate ventilation, avoid ingestion and inhalation of powders
Unusual Hazards: Prolonged inhalation of dust may cause mild respiratory irritation, not listed as carcinogenic or mutagenic
Potential Health Effects: High airborne exposure could irritate mucous membranes

Composition / Information on Ingredients

Chemical Identity: L-Threonine
Purity: Typically ≥ 98%
Impurities: Trace amounts of related amino acids, water
Other Ingredients: None expected in pure product
Additional Additives: None unless mixed or formulated for feed

First Aid Measures

Inhalation: Move affected person to fresh air, seek medical attention if symptoms persist
Eye Contact: Immediately rinse opened eye under running water for several minutes, see physician if irritation develops
Skin Contact: Remove contaminated clothing, wash skin with soap and water, medical help if irritation occurs
Ingestion: Rinse mouth with water, never give anything by mouth to an unconscious person, contact medical professional if unease appears

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, foam, dry powder, or carbon dioxide
Specific Hazards: Combustion may produce CO, CO2, and nitrogen oxides
Protective Equipment: Firefighters wear full protective clothing and self-contained breathing apparatus
Explosion Risk: Fine dust dispersed in air may ignite at high concentrations, minimize dust accumulation away from ignition sources

Accidental Release Measures

Personal Precautions: Prevent contact with eyes, skin, and clothing, avoid breathing dust, ventilate area
Environmental Precautions: Prevent entry into waterways, drains, or soil
Cleanup Methods: Use vacuum or wet sweeping to collect material, transfer to proper waste container, avoid raising dust, flush area with water

Handling and Storage

Handling: Operate in well-ventilated space, minimize dust formation, wear personal protective equipment suited for powder handling, avoid direct contact
Hygiene Practices: Do not eat, drink, or smoke while working with L-Threonine, wash hands thoroughly after handling, keep work clothes separate
Storage Conditions: Store in tightly closed container in cool, dry, well-ventilated space, protect from moisture and incompatible materials like strong oxidizers, maintain original packaging integrity

Exposure Controls and Personal Protection

Occupational Limits: No specific OSHA, ACGIH, or EU exposure limits established
Engineering Controls: Use local exhaust ventilation to minimize airborne concentrations, ensure eye wash stations and safety showers remain accessible
Personal Protective Equipment: Wear safety goggles, gloves made from resistant material, dust mask or respirator for prolonged exposure, use protective clothing
Additional Precautions: Maintain good industrial hygiene, wash hands before breaks, avoid direct inhalation and eye/skin exposure

Physical and Chemical Properties

Appearance: White crystalline powder
Odor: Odorless
Solubility: Freely soluble in water, practically insoluble in ethanol or ether
Melting Point: About 256 °C (dec.)
Boiling Point: Not applicable (decomposes on heating)
pH Value: Aqueous solution ranges from pH 5.2 to 6.2
Vapor Pressure: Negligible
Bulk Density: 0.4 - 0.7 g/cm3

Stability and Reactivity

Chemical Stability: Stable under normal storage and handling conditions
Hazardous Reactions: Not known to react hazardously under expected use environments
Incompatibility: Strong oxidizing agents, strong acids
Decomposition Products: Fire generates CO, CO2, nitrogen oxides, potentially ammonia
Polymerization: Does not occur

Toxicological Information

Acute Toxicity: Practically non-toxic by ingestion, inhalation, or skin contact based on animal studies
Irritation: Dust may cause eye or respiratory irritation
Sensitization: Not expected to cause allergic reaction
Carcinogenicity: Not listed by NTP, IARC, or OSHA as a carcinogen
Chronic Effects: No evidence of chronic toxicity in occupational or animal exposure studies
Mutagenicity/Teratogenicity: No findings from available data
Further Health Data: Product does not bioaccumulate or present cumulative risk at recommended uses

Ecological Information

Eco-Toxicology: Low environmental risk, rapidly biodegradable, not toxic to aquatic or soil organisms at likely exposure levels
Mobility in Soil: High water solubility, migrates readily in aqueous phase
Persistence/Degradability: Readily broken down by natural microbial activity
Bioaccumulation: Does not accumulate in tissues
Additional Info: Large spills may contribute to local eutrophication

Disposal Considerations

Waste Treatment: Dispose in accordance with all local, regional, and national regulations
Product Disposal: Can typically be disposed of as non-hazardous waste
Container Treatment: Rinse empty containers well before recycling or disposal, avoid unintentional release into the environment
Special Handling: Avoid creation of dust during disposal operations, collect spilled residues for waste containment

Transport Information

UN Number: Not regulated
Transport Hazard Class: Not classified as dangerous for transport
Packing Group: Not assigned
Labels: No hazard label required
Additional Advice: Ship in closed containers, protect against moisture, keep separate from incompatible substances

Regulatory Information

U.S. TSCA Inventory: Listed
EU REACH Status: Registered and compliant
Canada DSL/NDSL: Listed
WHMIS Classification: Not classified as controlled product
Other Regulations: Not subject to specific international, federal, or local trade restrictions related to hazardous materials
Safety, Health, Environmental: Observe mandated labor and environmental safeguards where local regulations require